David Priest to Methotrexate
This is a "connection" page, showing publications David Priest has written about Methotrexate.
Connection Strength
0.559
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Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice. Cancer Chemother Pharmacol. 1994; 34(6):455-8.
Score: 0.106
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Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo. Cancer Res. 1989 Aug 01; 49(15):4204-9.
Score: 0.078
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Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells. Cancer Res. 1988 Jun 15; 48(12):3398-404.
Score: 0.072
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Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells. Cancer Lett. 1986 Jan; 30(1):55-9.
Score: 0.061
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Response of methylenetetrahydrofolate levels to methotrexate in Krebs ascites cells. Biochem J. 1983 Nov 15; 216(2):295-8.
Score: 0.053
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Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells. Adv Enzyme Regul. 1997; 37:59-76.
Score: 0.033
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Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood. 1994 Jul 15; 84(2):564-9.
Score: 0.028
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The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture. Adv Exp Med Biol. 1991; 309A:75-8.
Score: 0.022
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The effect of methionine on methotrexate metabolism in rat hepatocytes in monolayer culture. Biochim Biophys Acta. 1989 May 10; 1011(2-3):122-8.
Score: 0.019
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Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse. Cancer Res. 1986 May; 46(5):2230-5.
Score: 0.016
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Effects of growth rate and methotrexate on folate polyglutamates and folylpolyglutamate hydrolase activity in Krebs ascites cells. Biochem Cell Biol. 1986 Apr; 64(4):363-7.
Score: 0.016
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Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem J. 2002 Nov 01; 367(Pt 3):741-50.
Score: 0.012
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Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol. 1999 Apr; 55(4):761-9.
Score: 0.010
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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J Biol Chem. 1998 Nov 13; 273(46):30189-98.
Score: 0.009
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Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF). Adv Exp Med Biol. 1993; 338:775-8.
Score: 0.006
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Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin. Cancer Res. 1991 Feb 01; 51(3):789-93.
Score: 0.005
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Accumulation of tetrahydrofolates in human plasma after leucovorin administration. Cancer Chemother Pharmacol. 1989; 23(6):353-7.
Score: 0.005
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The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates. Adv Enzyme Regul. 1987; 26:147-55.
Score: 0.004
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Micellar high-performance liquid chromatographic determination of folylpolyglutamate hydrolase activity. J Chromatogr. 1986 Apr 23; 357(1):183-9.
Score: 0.004