"Mice, Inbred mdx" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
| Descriptor ID |
D018101
|
| MeSH Number(s) |
B01.050.050.199.520.520.420.500 B01.050.150.900.649.313.992.635.505.500.400.420.500 B01.050.150.900.649.313.992.635.505.500.550.265
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| Concept/Terms |
Mice, Inbred mdx- Mice, Inbred mdx
- Inbred mdx Mice
- Mouse, Inbred mdx
- Inbred mdx Mouse
- Mice, mdx
- mdx Mice
- Mouse, mdx
- mdx Mouse
|
Below are MeSH descriptors whose meaning is more general than "Mice, Inbred mdx".
- Organisms [B]
- Eukaryota [B01]
- Animals [B01.050]
- Animal Population Groups [B01.050.050]
- Animals, Laboratory [B01.050.050.199]
- Animals, Inbred Strains [B01.050.050.199.520]
- Mice, Inbred Strains [B01.050.050.199.520.520]
- Mice, Inbred C57BL [B01.050.050.199.520.520.420]
- Mice, Inbred mdx [B01.050.050.199.520.520.420.500]
- Chordata [B01.050.150]
- Vertebrates [B01.050.150.900]
- Mammals [B01.050.150.900.649]
- Eutheria [B01.050.150.900.649.313]
- Rodentia [B01.050.150.900.649.313.992]
- Muridae [B01.050.150.900.649.313.992.635]
- Murinae [B01.050.150.900.649.313.992.635.505]
- Mice [B01.050.150.900.649.313.992.635.505.500]
- Mice, Inbred Strains [B01.050.150.900.649.313.992.635.505.500.400]
- Mice, Inbred C57BL [B01.050.150.900.649.313.992.635.505.500.400.420]
- Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.400.420.500]
- Mice, Mutant Strains [B01.050.150.900.649.313.992.635.505.500.550]
- Mice, Inbred mdx [B01.050.150.900.649.313.992.635.505.500.550.265]
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred mdx".
This graph shows the total number of publications written about "Mice, Inbred mdx" by people in this website by year, and whether "Mice, Inbred mdx" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mice, Inbred mdx" by people in Profiles.
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NF-?B inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model. Nat Commun. 2018 08 24; 9(1):3431.
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NF-?B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest. 2013 Nov; 123(11):4821-35.
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Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Mol Ther. 2012 Jun; 20(6):1222-33.
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NF-?B negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther. 2012 Mar; 20(3):661-8.
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Systemic delivery of NEMO binding domain/IKK? inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis. 2011 Sep; 43(3):598-608.
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Peptide-based inhibition of NF-?B rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med. 2011 May-Jun; 17(5-6):508-15.
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Inhibition of the IKK/NF-?B pathway by AAV gene transfer improves muscle regeneration in older mdx mice. Gene Ther. 2010 Dec; 17(12):1476-83.
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Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention. Int Rev Immunol. 2008; 27(5):375-87.
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Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 2005 Nov; 8(5):421-32.