Receptors, Prostaglandin E, EP4 Subtype
"Receptors, Prostaglandin E, EP4 Subtype" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.
| Descriptor ID |
D058309
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| MeSH Number(s) |
D12.776.543.750.695.200.700.600.400
|
| Concept/Terms |
Receptors, Prostaglandin E, EP4 Subtype- Receptors, Prostaglandin E, EP4 Subtype
- Prostaglandin E Receptor 4
- Prostaglandin EP4 Receptors
- EP4 Receptors, Prostaglandin
- Receptors, Prostaglandin EP4
- Prostanoid Receptor EP4
- EP4, Prostanoid Receptor
- Receptor EP4, Prostanoid
- Receptor, Prostaglandin EP4
- EP4 Receptor, Prostaglandin
- Prostaglandin EP4 Receptor
- PGE Receptor, EP4 Subtype
- Prostaglandin E2 Receptor, EP4 Subtype
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Prostaglandin E, EP4 Subtype".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Prostaglandin E, EP4 Subtype".
This graph shows the total number of publications written about "Receptors, Prostaglandin E, EP4 Subtype" by people in this website by year, and whether "Receptors, Prostaglandin E, EP4 Subtype" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2013 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Prostaglandin E, EP4 Subtype" by people in Profiles.
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The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas. Cancer Prev Res (Phila). 2022 05 03; 15(5):285-296.
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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. Gastroenterology. 2015 Dec; 149(7):1884-1895.e4.
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EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii. Am J Reprod Immunol. 2014 Jan; 71(1):34-43.
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Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor. Pancreas. 2013 Apr; 42(3):467-74.
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Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. J Clin Invest. 2006 Nov; 116(11):3026-34.
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Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1492-7.
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Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006 Jan 01; 20(1):77-86.
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Increased prostacyclin and PGE2 stimulated cAMP production by macrophages from endotoxin-tolerant rats. Am J Physiol. 1998 05; 274(5):C1238-44.