"Aflatoxin B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
| Descriptor ID |
D016604
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| MeSH Number(s) |
D03.383.663.283.119.075 D03.633.100.150.119.075 D23.946.587.142.075
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Aflatoxin B1".
Below are MeSH descriptors whose meaning is more specific than "Aflatoxin B1".
This graph shows the total number of publications written about "Aflatoxin B1" by people in this website by year, and whether "Aflatoxin B1" was a major or minor topic of these publications.
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Below are the most recent publications written about "Aflatoxin B1" by people in Profiles.
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Mutagenesis by aflatoxin in M13 DNA: base-substitution mechanisms and the origin of strand bias. Mol Gen Genet. 1989 May; 217(1):20-5.
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Mechanisms of mutagenesis by a bulky DNA lesion at the guanine N7 position. Genetics. 1988 Dec; 120(4):863-73.
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DNA replication-blocking properties of adducts formed by aflatoxin B1-2,3-dichloride and aflatoxin B1-2,3-oxide. Mutat Res. 1987 Jul; 179(1):89-101.
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Sequence context effects in DNA replication blocks induced by aflatoxin B1. Proc Natl Acad Sci U S A. 1985 May; 82(10):3096-100.
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Some practical problems arising from use of the gamma multihit model for risk estimation. J Toxicol Environ Health. 1981 Sep; 8(3):379-86.