"Amitriptyline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
| Descriptor ID |
D000639
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.100 D04.615.181.384.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Amitriptyline".
Below are MeSH descriptors whose meaning is more specific than "Amitriptyline".
This graph shows the total number of publications written about "Amitriptyline" by people in this website by year, and whether "Amitriptyline" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amitriptyline" by people in Profiles.
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Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E131-E144.
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A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Support Care Cancer. 2011 Jun; 19(6):833-41.
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Treatments used in women with interstitial cystitis: the interstitial cystitis data base (ICDB) study experience. The Interstitial Cystitis Data Base Study Group. Urology. 2000 Dec 20; 56(6):940-5.
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Response of psychotic depression subtypes to pharmacotherapy. J Affect Disord. 1993 Jun; 28(2):125-31.
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Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression. Am J Psychiatry. 1990 Sep; 147(9):1203-8.
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Ciguatera fish poisoning. J Am Acad Dermatol. 1989 Mar; 20(3):510-1.
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Amitriptyline excretion in human milk. J Clin Psychopharmacol. 1986 Dec; 6(6):383-4.
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Stress-induced immobility in rats with cholinergic supersensitivity. Biol Psychiatry. 1986 Jun; 21(7):657-64.
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A clinical report of thymoleptic-responsive atypical paranoid psychoses. Am J Psychiatry. 1983 Sep; 140(9):1187-90.
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Hypomania and tricyclic antidepressant choice. Am J Psychiatry. 1980 Nov; 137(11):1457-8.