"Saposins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred to as prosaposin.
| Descriptor ID |
D049231
|
| MeSH Number(s) |
D08.211.790.500
|
| Concept/Terms |
Saposin B- Saposin B
- Sphingolipid Activator Protein 1
- Sphingolipid Activator Protein-1
- SAP-1 Sphingolipid Activator
- SAP 1 Sphingolipid Activator
- Sphingolipid Activator, SAP-1
Saposin C- Saposin C
- beta-Glucosidase Stimulating Protein
- beta Glucosidase Stimulating Protein
- Co-beta-Glucosidase
- Co beta Glucosidase
- Sphingolipid Activator Protein 2
- Gaucher Activator Protein
- Glucosylceramidase Activator
- SAP-C Protein
- SAP C Protein
- beta-Glucosidase Activator Protein
- beta Glucosidase Activator Protein
- Coglucosidase
|
Below are MeSH descriptors whose meaning is more general than "Saposins".
Below are MeSH descriptors whose meaning is more specific than "Saposins".
This graph shows the total number of publications written about "Saposins" by people in this website by year, and whether "Saposins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2013 | 3 | 1 | 4 |
| 2015 | 2 | 1 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Saposins" by people in Profiles.
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Systemic enzyme delivery by blood-brain barrier-penetrating SapC-DOPS nanovesicles for treatment of neuronopathic Gaucher disease. EBioMedicine. 2020 May; 55:102735.
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Combination of acid ?-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype. Sci Rep. 2019 04 03; 9(1):5571.
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Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging. 2016 Feb; 38:141-150.
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Role of saposin C and D in auditory and vestibular function. Laryngoscope. 2016 Feb; 126(2):452-9.
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Spiral ganglion degeneration and hearing loss as a consequence of satellite cell death in saposin B-deficient mice. J Neurosci. 2015 Feb 18; 35(7):3263-75.
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Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma. Mol Ther. 2013 Aug; 21(8):1517-25.
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Altered autophagy in the mice with a deficiency of saposin A and saposin B. Autophagy. 2013 Jul; 9(7):1115-6.
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Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease. PLoS One. 2013; 8(3):e57560.
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Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet. 2013 Jun 15; 22(12):2435-50.
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Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4357-64.