"Phosphonoacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
| Descriptor ID |
D010746
|
| MeSH Number(s) |
D02.241.081.018.677 D02.705.429.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phosphonoacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Phosphonoacetic Acid".
This graph shows the total number of publications written about "Phosphonoacetic Acid" by people in this website by year, and whether "Phosphonoacetic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphonoacetic Acid" by people in Profiles.
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Phase II study of N-phosphonacetyl-L-aspartate, recombinant interferon-alpha, and fluorouracil infusion in advanced squamous cell carcinoma of the head and neck. Head Neck. 1998 Aug; 20(5):385-91.
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PALA enhancement of bromodeoxyuridine incorporation into DNA increases radiation cytotoxicity to human ovarian adenocarcinoma cells. Int J Radiat Oncol Biol Phys. 1996 Mar 15; 34(5):1073-9.
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Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3'-5' exonuclease domain. J Virol. 1993 Jul; 67(7):4323-36.
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Wider access provided to AIDS drugs with actions against HIV, CMV infections. JAMA. 1990 Oct 17; 264(15):1926.
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A phase II study of PALA (NSC 224131) in patients with advanced ovarian carcinoma. A Gynecologic Oncology Group study. Am J Clin Oncol. 1984 Jun; 7(3):257-60.