"Heavy Chain Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
| Descriptor ID |
D006362
|
| MeSH Number(s) |
C15.378.147.780.490 C15.604.515.435 C20.683.780.490
|
| Concept/Terms |
gamma-Chain Disease- gamma-Chain Disease
- gamma Chain Disease
- gamma-Chain Diseases
- Franklin Disease
- Franklin's Disease
- Franklins Disease
|
Below are MeSH descriptors whose meaning is more general than "Heavy Chain Disease".
Below are MeSH descriptors whose meaning is more specific than "Heavy Chain Disease".
This graph shows the total number of publications written about "Heavy Chain Disease" by people in this website by year, and whether "Heavy Chain Disease" was a major or minor topic of these publications.
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Below are the most recent publications written about "Heavy Chain Disease" by people in Profiles.
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Asynchronous development of two monoclonal proteins (IgM lambda and delta 1 chains) in a patient with abdominal lymphoma. Cancer. 1977 May; 39(5):2247-53.