rap1 GTP-Binding Proteins
"rap1 GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D020827
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.475.100 D12.644.360.525.475.100 D12.776.157.325.515.475.100 D12.776.476.525.475.100
|
| Concept/Terms |
rap1 GTP-Binding Protein- rap1 GTP-Binding Protein
- GTP-Binding Protein, rap1
- rap1 GTP Binding Protein
- rap1A Protein
- smg p21 GTP-Binding Protein
- smg p21 GTP Binding Protein
- smg p21A Protein
- p21A Protein, smg
- rap1A GTP-Binding Protein
- GTP-Binding Protein, rap1A
- rap1A GTP Binding Protein
- Krev-1 GTP-Binding Protein
- GTP-Binding Protein, Krev-1
- Krev 1 GTP Binding Protein
- SMG p21A GTP-Binding Protein
- SMG p21A GTP Binding Protein
- Krev-1 Protein
- Krev 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "rap1 GTP-Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "rap1 GTP-Binding Proteins".
This graph shows the total number of publications written about "rap1 GTP-Binding Proteins" by people in this website by year, and whether "rap1 GTP-Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "rap1 GTP-Binding Proteins" by people in Profiles.
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The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. J Cell Sci. 2017 03 15; 130(6):1094-1109.
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Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. J Cell Sci. 2017 01 01; 130(1):152-163.
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Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Res. 2010 Jun 01; 70(11):4590-601.
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The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas. Oncogene. 2010 Jan 28; 29(4):608-15.
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Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. J Biol Chem. 2009 Oct 16; 284(42):28522-32.
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A novel protein geranylgeranyltransferase-I inhibitor with high potency, selectivity, and cellular activity. J Biol Chem. 2006 May 05; 281(18):12445-50.
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Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem. 2003 Oct 24; 278(43):41756-67.
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The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration. J Immunol. 2002 Aug 01; 169(3):1365-71.
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Activation and function of the Rap1 GTPase in B lymphocytes. Int Rev Immunol. 2001; 20(6):763-89.
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Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. Immunol Rev. 2000 Aug; 176:47-68.