"Hyperhomocysteinemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
| Descriptor ID |
D020138
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| MeSH Number(s) |
C16.320.565.100.480 C18.452.603.378 C18.452.648.100.480 C18.654.521.500.133.699.418
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hyperhomocysteinemia".
Below are MeSH descriptors whose meaning is more specific than "Hyperhomocysteinemia".
This graph shows the total number of publications written about "Hyperhomocysteinemia" by people in this website by year, and whether "Hyperhomocysteinemia" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hyperhomocysteinemia" by people in Profiles.
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Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of M?ller glial cells and NRF2. Redox Biol. 2019 06; 24:101199.
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Relationship between homocysteine and hypertension: New data add to the debate. J Clin Hypertens (Greenwich). 2017 11; 19(11):1171-1172.
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Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the ?-amyloid fibrinogen interaction. J Thromb Haemost. 2016 07; 14(7):1442-52.
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Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: a prospective study. Atherosclerosis. 2014 Sep; 236(1):188-195.
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Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Jan; 42(1):227-76.
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Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke. 2005 Jun; 36(6):1207-11.
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Risk factors for progression of aortic atheroma in stroke and transient ischemic attack patients. Stroke. 2002 Apr; 33(4):930-5.
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Hyperhomocysteinemia and inflammatory bowel disease: prevalence and predictors in a cross-sectional study. Am J Gastroenterol. 2001 Jul; 96(7):2143-9.