"Pentylenetetrazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
| Descriptor ID |
D010433
|
| MeSH Number(s) |
D03.383.066.600
|
| Concept/Terms |
Pentylenetetrazole- Pentylenetetrazole
- Pentylenetetrazol
- Pentetrazole
- Leptazole
- Pentamethylenetetrazole
Corasol- Corasol
- Corazole
- Korazole
- Corazol
- Korazol
|
Below are MeSH descriptors whose meaning is more general than "Pentylenetetrazole".
Below are MeSH descriptors whose meaning is more specific than "Pentylenetetrazole".
This graph shows the total number of publications written about "Pentylenetetrazole" by people in this website by year, and whether "Pentylenetetrazole" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentylenetetrazole" by people in Profiles.
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Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. Neuroscience. 2014 Feb 14; 259:142-54.
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Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience. 2010 Jan 13; 165(1):130-7.
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Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. J Neurosci. 2008 Aug 27; 28(35):8801-9.
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Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice. Psychopharmacology (Berl). 1998 Sep; 139(1-2):145-53.
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Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):923-7.
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The role of the nucleus accumbens in sensitization to drugs of abuse. Prog Neuropsychopharmacol Biol Psychiatry. 1992 Mar; 16(2):237-46.
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Studies on the contribution of active metabolites to the anticonvulsant effects of propranolol. Eur J Pharmacol. 1977 Mar 07; 42(1):39-46.