Multidrug Resistance-Associated Proteins
"Multidrug Resistance-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 family of proteins.
| Descriptor ID |
D027425
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| MeSH Number(s) |
D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500
|
| Concept/Terms |
Multidrug Resistance-Associated Proteins- Multidrug Resistance-Associated Proteins
- Multidrug Resistance Associated Proteins
- Multispecific Organic Anion Transporter
- Multispecific Organic Anion Transport Proteins
- ATP-Binding Cassette, Sub-Family C Proteins
- ATP Binding Cassette, Sub Family C Proteins
- MOAT Protein
- Multidrug Resistance-Associated Protein
- Multidrug Resistance Associated Protein
- Resistance-Associated Protein, Multidrug
|
Below are MeSH descriptors whose meaning is more general than "Multidrug Resistance-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "Multidrug Resistance-Associated Proteins".
This graph shows the total number of publications written about "Multidrug Resistance-Associated Proteins" by people in this website by year, and whether "Multidrug Resistance-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multidrug Resistance-Associated Proteins" by people in Profiles.
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Genetic polymorphisms in candidate genes are not associated with increased vincristine-related peripheral neuropathy in Arab children treated for acute childhood leukemia: a single institution study. Pharmacogenet Genomics. 2018 08; 28(8):189-195.
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Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells. Dig Dis Sci. 2016 Feb; 61(2):453-63.
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Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2014 Aug; 24(8):387-96.
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Iron N-(2-hydroxy acetophenone) glycinate (FeNG), a non-toxic glutathione depletor circumvents doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo. Biometals. 2012 Feb; 25(1):149-63.
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Phosphorylation of radixin regulates cell polarity and Mrp-2 distribution in hepatocytes. Am J Physiol Cell Physiol. 2011 Mar; 300(3):C416-24.
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Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res (Phila). 2008 Jul; 1(2):93-9.
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Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16394-9.
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Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol Pharmacol. 2004 May; 65(5):1070-9.
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Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
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The xenobiotic transporter, MRP2, in epithelia from insects, sharks, and the human breast: implications for health and disease. J Exp Zool A Comp Exp Biol. 2003 Nov 01; 300(1):91-7.