"Complement C9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
| Descriptor ID |
D003186
|
| MeSH Number(s) |
D12.776.124.486.274.850
|
| Concept/Terms |
Complement C9- Complement C9
- C9, Complement
- Complement 9
- Complement Component 9
- Component 9, Complement
- C9 Complement
- Complement, C9
|
Below are MeSH descriptors whose meaning is more general than "Complement C9".
Below are MeSH descriptors whose meaning is more specific than "Complement C9".
This graph shows the total number of publications written about "Complement C9" by people in this website by year, and whether "Complement C9" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C9" by people in Profiles.
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Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem. 2011 Jun 10; 286(23):20952-62.
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Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex. Acta Crystallogr D Biol Crystallogr. 2007 Jun; 63(Pt 6):714-21.
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Defining the CD59-C9 binding interaction. J Biol Chem. 2006 Sep 15; 281(37):27398-404.
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Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J Immunol. 2003 Feb 01; 170(3):1517-23.