"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
| Descriptor ID |
D016874
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| MeSH Number(s) |
A08.675.609.520 A11.284.430.214.190.750.640.520 A11.671.573.520
|
| Concept/Terms |
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
|
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in this website by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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T Lymphocytes in the Pathogenesis and Progression of Alzheimer's Disease: Pursuing Direct Neuropathological Evidence. Curr Alzheimer Res. 2023; 20(7):453-458.
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Diffusion MRI detects longitudinal white matter changes in the 3xTg-AD mouse model of Alzheimer's disease. Magn Reson Imaging. 2019 04; 57:235-242.
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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs). J Med Chem. 2016 05 26; 59(10):4778-89.
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Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study. Brain Res. 2013 May 01; 1508:1-8.
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Value in development of a TAPIR-like mouse monoclonal antibody to Abeta. J Alzheimers Dis. 2008 Jun; 14(2):175-7.
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Clinicopathologic case report: progressive aphasia in a 77-year-old man. J Neuropsychiatry Clin Neurosci. 2003; 15(2):231-8.
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Senile plaques exert no mass lesion effect on surrounding neurons. J Neurosci Methods. 2001 Sep 30; 110(1-2):125-33.