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Baatz, John
One or more keywords matched the following properties of Baatz, John
PropertyValue
keywords Neonatal lung diseases
keywords Oxygen homeostasis and lung disease
keywords Lung cryopreservation
keywords Effects of oxygen on lung development
overview The focus of the research projects in our laboratory is the effects of hypoxic stress and marine-borne toxin exposure on the distal lung, specifically with respect to responses of alveolar cells. This research currently encompasses four research projects. The first of these examines the roles of hemoglobin, recently identified by our laboratory as being expressed in alveolar type II cells, in nitrosative and oxidative stress as well as surfactant protein expression. Secondly we are developing a porous hollow fiber system that permits culture of embryonic stem cells, primary airway cells and immortalized airway cells within the fiber at an air/water interface. We are also using this system to assess adaptations diving marine mammals (such as dolphins, seals and whales) have made to repetitive hypoxic conditions while being able to maintain lung health. This unique technique may be useful in reducing the use of animals in studying distal lung during health, disease or injury, and may also serve as a system to repopulate diseased or injured airway cells with health cells. We continue to examine structural/function relationships of pulmonary surfactant proteins and the effects of marine-borne toxins (such as red-tide toxins) on lung health. This is an exciting untapped field of study and has direct impacts on human lung health since humans share the often-polluted coastal waters, whether by recreation or work related, with dolphins, whales and manatees. This project utilizes proteomic and molecular biologic techniques in an effort to identify proteins and specific mechanistic pathways in airway cells that are altered in expression or secretion as a result of toxin exposure. Finally, as Director of the MUSC Gel Proteomics facility, I am interested in development of novel separations and labeling techniques to identify, in a variety of species, disease-specific protein biomarkers and effects of drugs or stress on subcellular organelle proteins.
One or more keywords matched the following items that are connected to Baatz, John
Item TypeName
Academic Article Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice.
Academic Article Effects of lung surfactant proteolipid SP-C on the organization of model membrane lipids: a fluorescence study.
Academic Article Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins.
Academic Article Characterization of alveolar epithelial cells cultured in semipermeable hollow fibers.
Academic Article Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection.
Academic Article Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury.
Academic Article Surfactant protein A-polylysine conjugates for delivery of DNA to airway cells in culture.
Academic Article Differential activity and lack of synergy of lung surfactant proteins SP-B and SP-C in interactions with phospholipids.
Academic Article Biophysical inhibition of synthetic phospholipid-lung surfactant apoprotein admixtures by plasma proteins.
Academic Article Oral instillation with surfactant phospholipid: a reliable alternative to intratracheal injection in mouse studies.
Academic Article Cryopreservation and in vitro culture of primary cell types from lung tissue of a stranded pygmy sperm whale (Kogia breviceps).
Academic Article Surfactant peptides stimulate uptake of phosphatidylcholine by isolated cells.
Academic Article Distinct effects of SP-A and SP-B on endocytosis of SP-C by pulmonary epithelial cells.
Concept Lung Neoplasms
Concept Lung Injury
Concept Lung Diseases
Concept Lung
Academic Article Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice.
Academic Article Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation.
Academic Article Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture.
Academic Article Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells.
Academic Article Transforming growth factor ?1 (TGF?1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts.
Academic Article Systemic sclerosis biomarkers detection in the secretome of TGF?1-activated primary human lung fibroblasts.
Academic Article Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
Academic Article Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
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