Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Bastia, Deepak
One or more keywords matched the following properties of Bastia, Deepak
PropertyValue
keywords Chromosome kissing and long range protein-protein and protein-DNA interaction in controlling DNA transactions and cancer
overview The primary focus of our laboratory is on the investigations of the molecular mechanisms of replication fork arrest, genome stability, checkpoint controls using Saccharomyces cerevisiae and Schizosaccharomyces pombe as model systems. These are topics of intense current interest not only from the perspectives of eukaryotic DNA transactions but also of Cancer Biology. Our laboratory is also interested in the molecular analysis of the human “timeless” protein and TIPIN (timeless-interacting protein). Molecular Mechanisms of Cellular Aging. Recently, using yeast as a model system, we have worked out one (the major) pathway of cellular aging. We have shown that two molecular mechanisms act in a sequence to control replicative life span: (i) autoinhibition of a replication terminator protein called Fob1 and chromosome kissing. Further work is underway to study the molecular mechanisms that lead to aging and senescence. Our laboratory offers outstanding training in nucleic acids biochemistry, enzymology of DNA replication and on protein nucleic acids and protein-protein interactions.
One or more keywords matched the following items that are connected to Bastia, Deepak
Item TypeName
Academic Article Mechanistic studies on the impact of transcription on sequence-specific termination of DNA replication and vice versa.
Academic Article Activation of distant replication origins in vivo by DNA looping as revealed by a novel mutant form of an initiator protein defective in cooperativity at a distance.
Academic Article Mechanism of recruitment of DnaB helicase to the replication origin of the plasmid pSC101.
Academic Article Mechanistic studies of initiator-initiator interaction and replication initiation.
Academic Article Conformational changes induced by integration host factor at origin gamma of R6K and copy number control.
Academic Article Replication of plasmid R6K origin gamma in vitro. Dependence on dual initiator proteins and inhibition by transcription.
Academic Article Structural and functional analysis of a bipolar replication terminus. Implications for the origin of polarity of fork arrest.
Academic Article Termination of DNA replication of bacterial and plasmid chromosomes.
Academic Article Structural and functional analysis of a replication enhancer: separation of the enhancer activity from origin function by mutational dissection of the replication origin gamma of plasmid R6K.
Academic Article Escherichia coli replication terminator protein impedes simian virus 40 (SV40) DNA replication fork movement and SV40 large tumor antigen helicase activity in vitro at a prokaryotic terminus sequence.
Academic Article Reconstitution of R6K DNA replication in vitro using 22 purified proteins.
Academic Article Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest.
Academic Article swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe.
Academic Article DNA-protein interaction at the replication termini of plasmid R6K.
Academic Article Replication terminator protein of Escherichia coli is a transcriptional repressor of its own synthesis.
Academic Article Oligomeric initiator protein-mediated DNA looping negatively regulates plasmid replication in vitro by preventing origin melting.
Academic Article The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.
Academic Article Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex.
Academic Article Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication.
Academic Article A replication terminus located at or near a replication checkpoint of Bacillus subtilis functions independently of stringent control.
Academic Article A single domain of the replication termination protein of Bacillus subtilis is involved in arresting both DnaB helicase and RNA polymerase.
Academic Article The DNA-binding domain of HPV-16 E2 protein interaction with the viral enhancer: protein-induced DNA bending and role of the nonconserved core sequence in binding site affinity.
Academic Article Nucleotide sequence determination of a strong promoter of the colicin E 1 plasmid. Analysis of restriction sites protected by RNA polymerase interactions before and after limited transcription.
Academic Article Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.
Academic Article Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest.
Academic Article Mechanisms of polar arrest of a replication fork.
Academic Article Investigations of pi initiator protein-mediated interaction between replication origins alpha and gamma of the plasmid R6K.
Academic Article Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae.
Academic Article Regulation of replication termination by Reb1 protein-mediated action at a distance.
Academic Article The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.
Academic Article A host-encoded DNA-binding protein promotes termination of plasmid replication at a sequence-specific replication terminus.
Academic Article The replication terminator protein of E. coli is a DNA sequence-specific contra-helicase.
Academic Article DnaA protein is required for replication of the minimal replicon of the broad-host-range plasmid RK2 in Escherichia coli.
Academic Article DNA-protein interaction at the replication origins of plasmid chromosomes.
Academic Article Conformational changes in a replication origin induced by an initiator protein.
Academic Article The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein.
Academic Article The integration host factor of Escherichia coli binds to bent DNA at the origin of replication of the plasmid pSC101.
Academic Article Heterogeneity, complexity, and repetition of the chloroplast DNA of Chlamydomonas reinhardtii.
Academic Article Primary structure of the replication initiation protein of plasmid R6K.
Academic Article The replication initiator protein of plasmid R6K tagged with beta-galactosidase shows sequence-specific DNA-binding.
Academic Article DNA-protein interaction at the origin of DNA replication of the plasmid pSC101.
Academic Article Primary structure of the essential replicon of the plasmid pSC101.
Academic Article Studies on the late replication of phage lambda: rolling-circle replication of the wild type and a partially suppressed strain, Oam29 Pam80.
Academic Article The nucleotide sequence surrounding the replication terminus of R6K.
Academic Article Cooperativity at a distance promoted by the combined action of two replication initiator proteins and a DNA bending protein at the replication origin of pSC101.
Academic Article A 27 kd protein of E. coli promotes antitermination of replication in vitro at a sequence-specific replication terminus.
Academic Article The replication initiator protein pi of the plasmid R6K specifically interacts with the host-encoded helicase DnaB.
Academic Article The relationship between sequence-specific termination of DNA replication and transcription.
Academic Article Direct physical interaction between DnaG primase and DnaB helicase of Escherichia coli is necessary for optimal synthesis of primer RNA.
Academic Article Helicase-contrahelicase interaction and the mechanism of termination of DNA replication.
Academic Article Termination of DNA replication in prokaryotic chromosomes.
Academic Article Biochemical investigations of control of replication initiation of plasmid R6K.
Academic Article Reconstitution of F factor DNA replication in vitro with purified proteins.
Academic Article Activation in vivo of the minimal replication origin beta of plasmid R6K requires a small target sequence essential for DNA looping.
Academic Article Crystallization and preliminary structural analysis of the replication terminator protein of Bacillus subtilis.
Academic Article The DnaK-DnaJ-GrpE chaperone system activates inert wild type pi initiator protein of R6K into a form active in replication initiation.
Academic Article Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombe and causes polar replication fork arrest.
Academic Article Sequence-specific and polarized replication termination in vitro: complementation of extracts of tus- Escherichia coli by purified Ter protein and analysis of termination intermediates.
Academic Article Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase.
Academic Article The nucleotide sequence surrounding the origin of DNA replication of Col E1.
Academic Article Replication initiation at a distance: determination of the cis- and trans-acting elements of replication origin alpha of plasmid R6K.
Academic Article A replication origin is turned off by an origin-"silencer" sequence.
Academic Article A replication initiator protein enhances the rate of hybrid formation between a silencer RNA and an activator RNA.
Academic Article DNA bending is induced in an enhancer by the DNA-binding domain of the bovine papillomavirus E2 protein.
Academic Article Interaction of the bovine papillomavirus type 1 E2 transcriptional control protein with the viral enhancer: purification of the DNA-binding domain and analysis of its contact points with DNA.
Academic Article The replication initiator protein of plasmid pSC101 is a transcriptional repressor of its own cistron.
Academic Article Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein.
Academic Article Detection of DNA looping due to simultaneous interaction of a DNA-binding protein with two spatially separated binding sites on DNA.
Academic Article Determination of restriction sites and the nucleotide sequence surrounding the relaxation site of ColE1.
Academic Article Replication initiator protein of plasmid R6K autoregulates its own synthesis at the transcriptional step.
Academic Article Interaction of the plasmid R6K-encoded replication initiator protein with its binding sites on DNA.
Academic Article The nucleotide sequence of the replication origin beta of the plasmid R6K.
Academic Article Use of gene fusions and protein-protein interaction in the isolation of a biologically active regulatory protein: the replication initiator protein of plasmid R6K.
Academic Article Termination of DNA replication in vitro at a sequence-specific replication terminus.
Academic Article Molecular cloning of the replication terminus of the plasmid R6K.
Academic Article The contrahelicase activities of the replication terminator proteins of Escherichia coli and Bacillus subtilis are helicase-specific and impede both helicase translocation and authentic DNA unwinding.
Academic Article Termination of DNA replication in vitro: requirement for stereospecific interaction between two dimers of the replication terminator protein of Bacillus subtilis and with the terminator site to elicit polar contrahelicase and fork impedance.
Academic Article Crystal structure of the replication terminator protein from B. subtilis at 2.6 A.
Academic Article The replication terminator protein of the gram-positive bacterium Bacillus subtilis functions as a polar contrahelicase in gram-negative Escherichia coli.
Academic Article Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number.
Academic Article The dimer-dimer interaction surface of the replication terminator protein of Bacillus subtilis and termination of DNA replication.
Academic Article The structure and function of the replication terminator protein of Bacillus subtilis: identification of the 'winged helix' DNA-binding domain.
Academic Article Structural aspects of protein-DNA interactions as revealed by conversion of the interacting protein into a sequence-specific cross-linking agent or a chemical nuclease.
Academic Article Structure of the replication terminus-terminator protein complex as probed by affinity cleavage.
Concept DNA, Ribosomal
Concept DNA-Binding Proteins
Concept DNA Topoisomerases, Type II
Concept DNA Helicases
Concept DNA Topoisomerases, Type I
Concept Random Amplified Polymorphic DNA Technique
Concept DNA Ligases
Concept DNA
Concept DNA, Intergenic
Concept DNA, Circular
Concept DNA, Fungal
Concept DNA Primers
Concept DNA Fingerprinting
Concept DNA Primase
Concept DNA, Superhelical
Concept DNA, Bacterial
Concept DNA, Recombinant
Concept DNA, Ribosomal Spacer
Concept DNA Probes
Concept DNA, Plant
Concept DNA Replication
Concept DNA Restriction Enzymes
Concept DNA-Directed RNA Polymerases
Concept DNA, Single-Stranded
Academic Article Mechanism and physiological significance of programmed replication termination.
Academic Article Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance.
Academic Article Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex.
Academic Article Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
Academic Article Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae.
Academic Article Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.
Academic Article Isolation of useful scented rice mutants and comparative assessment of genetic diversity.
Academic Article Rapid purification of a cloned gene product by genetic fusion and site-specific proteolysis.
Search Criteria
  • DNA