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Lemasters, John

One or more keywords matched the following properties of Lemasters, John

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overview	I have a long-standing interest in hepatic ischemia-reperfusion (IR) injury, especially as it relates to organ preservation for transplantation. I and my colleagues were the first to show a prominent role for nonparenchymal cells in IR injury to cold-stored livers. Specifically, we showed that reperfusion after cold ischemic storage leads to killing of sinusoidal endothelial cells and activation of Kupffer cells. We were also pioneers in showing that onset of the mitochondrial permeability transition (MPT) then developed in hepatic parenchymal cells, leading to hepatic apoptosis, necrosis and graft failure, and we developed a variety of stratagems to ameliorate these injuries that are beginning to find clinical application. Overall, my laboratory has published over 350 papers in peer-reviewed journals plus more than 100 book chapters. Productive, long-term collaborations with both junior and senior colleagues contributed importantly to this success. My research interests continue to relate to mitochondrial and cellular bioenergetics, including studies of oxidative phosphorylation in isolated mitochondria, mitochondrial dysfunction in toxic, and hypoxic and reperfusion injury to liver and heart cells, and graft failure from preservation injury to livers stored for transplantation surgery. Our in vitro and in vivo studies of living cells and tissues have shown that mitochondrial calcium uptake, iron translocation from lysosomes to mitochondria, and oxidative stress promote the MPT. The MPT initially induces lysosomal degradation of mitochondria by autophagy, a selective process called mitophagy. However, excess MPT induction induces both necrotic cell death from ATP depletion and apoptosis due to cytochrome c release after mitochondrial swelling. For these projects, my laboratory extensively applies new techniques of quantitative laser scanning confocal and intravital multiphoton microscopy for physiological analysis of single cells and living organs. The lab also extensively employs Seahorse technology to measure respiration and glycolytic flux in cultured cells. Current projects are examining how iron mobilization from lysosomes to cytosol and then to mitochondria during cold ischemic liver storage sensitizes hepatocytes and nonparenchymal cells to adverse events after reperfusion, leading ultimately to injury and failure of liver grafts. Despite a detailed understanding of their metabolism, mitochondria often behave anomalously. In particular, global suppression of mitochondrial metabolism and metabolite exchange occurs in apoptosis, ischemia/hypoxia, alcoholic liver disease and aerobic glycolysis in cancer cells (Warburg effect). My lab is also examining and supporting the novel hypothesis that closure of voltage-dependent anion channels (VDAC) in the mitochondrial outer membrane accounts for global mitochondrial suppression consistent with a role for VDAC as a dynamic regulator, or governator, of global mitochondrial function both in health and disease. In cancer cells, we showed that free tubulin causes closure of VDAC.

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overview

I have a long-standing interest in hepatic ischemia-reperfusion (IR) injury, especially as it relates to organ preservation for transplantation. I and my colleagues were the first to show a prominent role for nonparenchymal cells in IR injury to cold-stored livers. Specifically, we showed that reperfusion after cold ischemic storage leads to killing of sinusoidal endothelial cells and activation of Kupffer cells. We were also pioneers in showing that onset of the mitochondrial permeability transition (MPT) then developed in hepatic parenchymal cells, leading to hepatic apoptosis, necrosis and graft failure, and we developed a variety of stratagems to ameliorate these injuries that are beginning to find clinical application. Overall, my laboratory has published over 350 papers in peer-reviewed journals plus more than 100 book chapters. Productive, long-term collaborations with both junior and senior colleagues contributed importantly to this success. My research interests continue to relate to mitochondrial and cellular bioenergetics, including studies of oxidative phosphorylation in isolated mitochondria, mitochondrial dysfunction in toxic, and hypoxic and reperfusion injury to liver and heart cells, and graft failure from preservation injury to livers stored for transplantation surgery. Our in vitro and in vivo studies of living cells and tissues have shown that mitochondrial calcium uptake, iron translocation from lysosomes to mitochondria, and oxidative stress promote the MPT. The MPT initially induces lysosomal degradation of mitochondria by autophagy, a selective process called mitophagy. However, excess MPT induction induces both necrotic cell death from ATP depletion and apoptosis due to cytochrome c release after mitochondrial swelling. For these projects, my laboratory extensively applies new techniques of quantitative laser scanning confocal and intravital multiphoton microscopy for physiological analysis of single cells and living organs. The lab also extensively employs Seahorse technology to measure respiration and glycolytic flux in cultured cells. Current projects are examining how iron mobilization from lysosomes to cytosol and then to mitochondria during cold ischemic liver storage sensitizes hepatocytes and nonparenchymal cells to adverse events after reperfusion, leading ultimately to injury and failure of liver grafts. Despite a detailed understanding of their metabolism, mitochondria often behave anomalously. In particular, global suppression of mitochondrial metabolism and metabolite exchange occurs in apoptosis, ischemia/hypoxia, alcoholic liver disease and aerobic glycolysis in cancer cells (Warburg effect). My lab is also examining and supporting the novel hypothesis that closure of voltage-dependent anion channels (VDAC) in the mitochondrial outer membrane accounts for global mitochondrial suppression consistent with a role for VDAC as a dynamic regulator, or governator, of global mitochondrial function both in health and disease. In cancer cells, we showed that free tubulin causes closure of VDAC.

One or more keywords matched the following items that are connected to Lemasters, John

Item Type	Name
Academic Article	Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes.
Academic Article	Reperfusion injury to donor livers stored for transplantation.
Academic Article	Destruction of Kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol-treated rats.
Academic Article	Role of free radicals in primary nonfunction of marginal fatty grafts from rats treated acutely with ethanol.
Academic Article	Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes.
Academic Article	Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome.
Academic Article	Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in a low-flow, reflow model.
Academic Article	The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.
Academic Article	Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine.
Academic Article	Selective hepatic denervation prior to organ harvest improves survival after liver transplantation.
Academic Article	Targeted gene transfer to sinusoidal endothelial cells and expression in vivo.
Academic Article	Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine.
Academic Article	The mitochondrial permeability transition: from biochemical curiosity to pathophysiological mechanism.
Academic Article	The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release.
Academic Article	Intravenous glycine improves survival in rat liver transplantation.
Academic Article	Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers.
Academic Article	Amino acids in rinse effluents as a predictor of graft function after transplantation of fatty livers in rats.
Academic Article	Protection of sinusoidal endothelial cells against storage/reperfusion injury by prostaglandin E2 derived from Kupffer cells.
Academic Article	Secretory group IIA phospholipase A(2) generates anti-apoptotic survival signals in kidney fibroblasts.
Academic Article	The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes.
Academic Article	Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats.
Academic Article	Evidence that Carolina rinse solution protects sinusoidal endothelial cells against reperfusion injury after cold ischemic storage of rat liver.
Academic Article	Ethanol, not fat accumulation per se, increases free radical production in a low-flow, reflow liver perfusion model.
Academic Article	V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis.
Academic Article	The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187.
Academic Article	Involvement of Kupffer cells and sinusoidal endothelial cells in ischemic preconditioning to rat livers stored for transplantation.
Academic Article	Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes.
Academic Article	Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.
Academic Article	Role of cytokines and cytokine-producing cells in reperfusion injury to the liver.
Academic Article	Negative contrast imaging of mitochondria by confocal microscopy.
Academic Article	Gentle organ manipulation during harvest as a key determinant of survival of fatty livers after transplantation in the rat.
Academic Article	Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat.
Academic Article	Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes.
Academic Article	Heat shock suppresses the permeability transition in rat liver mitochondria.
Academic Article	Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats.
Academic Article	Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat.
Academic Article	Reduced-size liver transplantation in the mouse.
Academic Article	Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement.
Academic Article	Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization.
Academic Article	The calcium channel blocker nisoldipine minimizes the release of tumor necrosis factor and interleukin-6 following rat liver transplantation.
Academic Article	Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer.
Academic Article	Reperfusion injury: a role for neutrophils.
Academic Article	Suppression of Ca2+ oscillations in cultured rat hepatocytes by chemical hypoxia.
Academic Article	Warm Carolina rinse solution prevents graft failure from storage injury after orthotopic rat liver transplantation with arterialization.
Academic Article	Gentle in situ liver manipulation during organ harvest increases oxygen consumption in liver.
Academic Article	A novel cytotoxicity screening assay using a multiwell fluorescence scanner.
Academic Article	Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers.
Academic Article	Role of free radicals in failure of fatty liver grafts caused by ethanol.
Academic Article	Carolina rinse solution increases survival time dramatically after orthotopic liver transplantation in the rat.
Academic Article	Isolated mouse liver mitochondria are devoid of glucokinase.
Academic Article	Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols.
Academic Article	A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver.
Academic Article	Lipid order in hepatocyte plasma membrane blebs during ATP depletion measured by digitized video fluorescence polarization microscopy.
Academic Article	Role of pH in protection by low sodium against hypoxic injury in isolated perfused rat livers.
Academic Article	Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat.
Academic Article	Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat.
Academic Article	Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.
Academic Article	Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes.
Academic Article	Graft tumor necrosis factor receptor-1 protects after mouse liver transplantation whereas host tumor necrosis factor receptor-1 promotes injury.
Academic Article	Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes.
Academic Article	Kupffer cells mediate increased anoxic hepatocellular killing from hyperosmolarity by an oxygen- and prostaglandin-independent mechanism.
Academic Article	SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat.
Academic Article	Kupffer cells participate in rejection following liver transplantation in the rat.
Academic Article	Ischemic preconditioning of rat livers against cold storage-reperfusion injury: role of nonparenchymal cells and the phenomenon of heterologous preconditioning.
Academic Article	Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice.
Academic Article	Extrahepatic cells contribute to the progenitor/stem cell response following reduced-size liver transplantation in mice.
Academic Article	Role of apoptosis in acetaminophen hepatotoxicity.
Academic Article	Genetic manipulation of sinusoidal endothelial cells.
Academic Article	Prevention of early graft failure by the calcium channel blocker nisoldipine: involvement of Kupffer cells.
Academic Article	Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts.
Academic Article	Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2.
Academic Article	C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation.
Academic Article	Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion.
Academic Article	Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury.
Academic Article	Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes.
Academic Article	Mechanisms of hepatotoxicity.
Academic Article	Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?
Academic Article	Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals.
Academic Article	Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine.
Academic Article	Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes.
Academic Article	Cytosolic free magnesium, ATP and blebbing during chemical hypoxia in cultured rat hepatocytes.
Academic Article	Assessment of reperfusion injury by intravital fluorescence microscopy following liver transplantation in the rat.
Academic Article	Lack of metabolic effects of cholecystokinin on hepatocytes.
Academic Article	Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria.
Academic Article	Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts.
Academic Article	Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria.
Academic Article	Protective effect of nitrendipine against hypoxic injury in perfused livers from ethanol-treated rats.
Academic Article	Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
Academic Article	[The role of the voltage-dependent anion channels in the outer membrane of mitochondria in the regulation of cellular metabolism].
Academic Article	Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.
Academic Article	Mitophagy selectively degrades individual damaged mitochondria after photoirradiation.
Academic Article	Free tubulin modulates mitochondrial membrane potential in cancer cells.
Academic Article	Evidence that adenosine is a key component in Carolina rinse responsible for reducing graft failure after orthotopic liver transplantation in the rat.
Academic Article	Prevention of hepatic ischemia-reperfusion injury by green tea extract.
Academic Article	Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.
Academic Article	Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver.
Academic Article	Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.
Academic Article	Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde.
Academic Article	Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species.
Academic Article	Xanthine and hypoxanthine accumulation during storage may contribute to reperfusion injury following liver transplantation in the rat.
Academic Article	Reperfusion injury to endothelial cells following cold ischemic storage of rat livers.
Academic Article	Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation.
Academic Article	Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
Academic Article	Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide.
Academic Article	Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes.
Academic Article	Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: mitotracker probes and mitochondrial membrane potential.
Academic Article	Gliotoxin-mediated apoptosis of activated human hepatic stellate cells.
Academic Article	Functions of autophagy in normal and diseased liver.
Academic Article	Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties.
Academic Article	An ATP/2e-stoichiometry of 1 1/2 is thermodynamically possible for site 3 of oxidative phosphorylation.
Academic Article	Hepatic reperfusion injury following orthotopic liver transplantation in the rat.
Academic Article	Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes.
Academic Article	Possible role of the mitochondrial outer membrane as an oncotic regulator of mitochondrial volume.
Academic Article	Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability.
Academic Article	Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes.
Academic Article	Total protection from hypoxic liver damage by fructose.
Academic Article	Phosphate dependence and atractyloside inhibition of mitochondrial oxidative phosphorylation. The ADP-ATP carrier is rate-limiting.
Academic Article	Continuous measurement and rapid kinetics of ATP synthesis in rat liver mitochondria, mitoplasts and inner membrane vesicles determined by firefly-luciferase luminescence.
Academic Article	Lateral diffusion of ubiquinone during electron transfer in phospholipid- and ubiquinone-enriched mitochondrial membranes.
Academic Article	Metabolic heterogeneity in the perfused rat liver.
Academic Article	Alcohol-induced liver injury. The role of oxygen.
Academic Article	Thermodynamics of reverse electron transfer across site 1: ATP/2e- is greater than one.
Academic Article	The ATP-to-oxygen stoichiometries of oxidative phosphorylation by rat liver mitochondria. An analysis of ADP-induced oxygen jumps by linear nonequilibrium thermodynamics.
Academic Article	Stimulation of mixed-function oxidation of 7-ethoxycoumarin in periportal and pericentral regions of the perfused rat liver by xylitol.
Academic Article	Hypoxic hepatocellular injury.
Academic Article	Is hypoxia involved in the mechanism of alcohol-induced liver injury?
Academic Article	Fusion of liposomes with mitochondrial inner membranes.
Academic Article	A fluorometric method to measure sublobular rates of mixed-function oxidation in the hemoglobin-free perfused rat liver.
Academic Article	Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon.
Academic Article	Increase in survival of liver grafts after rinsing with warm Ringer's solution due to improvement of hepatic microcirculation.
Academic Article	Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.
Academic Article	Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes.
Academic Article	NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
Academic Article	Reperfusion rather than storage injury predominates following long-term (48 h) cold storage of grafts in UW solution: studies with Carolina Rinse in transplanted rat liver.
Academic Article	The second generation of Carolina Rinse, solution II, improves graft survival following orthotopic liver transplantation in the rat by preventing reperfusion injury.
Academic Article	Ethanol-induced changes in the intralobular oxygen gradient of perfused rat liver.
Academic Article	Centrilobular injury following hypoxia in isolated, perfused rat liver.
Academic Article	A non-invasive method to study metabolic events within sublobular regions of hemoglobin-free perfused liver.
Academic Article	The energized state of rat liver mitochondria. ATP equivalence, uncoupler sensitivity, and decay kinetics.
Academic Article	Relationships between bilayer lipid, motional freedom of oxidoreductase components, and electron transfer in the mitochondrial inner membrane.
Academic Article	The many facets of reperfusion injury.
Academic Article	Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide.
Academic Article	Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats.
Academic Article	Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species.
Academic Article	Evidence that activation of Kupffer cells increases oxygen uptake after cold storage.
Academic Article	Novel mechanisms in chemically induced hepatotoxicity.
Academic Article	Transient activation of hepatic glycogenolysis by thrombin in perfused rat livers.
Academic Article	Development of a new method for hepatic rearterialization in rat orthotopic liver transplantation. Reduction of liver injury and improvement of surgical outcome by arterialization.
Academic Article	Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL.
Academic Article	Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats.
Academic Article	The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.
Academic Article	Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals.
Academic Article	Protection by Carolina rinse solution, acidotic pH, and glycine against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation.
Academic Article	Amino acids in storage solution predict primary nonfunction in fatty liver grafts.
Academic Article	Reperfusion injury after liver preservation for transplantation.
Academic Article	Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases.
Academic Article	Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species.
Academic Article	Carolina rinse solution--a new strategy to increase survival time after orthotopic liver transplantation in the rat.
Academic Article	Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells.
Academic Article	Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx.
Academic Article	Rusty notions of cell injury.
Academic Article	Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats.
Academic Article	Adaptive Kupffer cell alterations after femur fracture trauma in rats.
Academic Article	Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism.
Academic Article	Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition.
Academic Article	c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.
Academic Article	Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion.
Academic Article	Carolina rinse solution protects adenosine triphosphate-depleted hepatocytes against lethal cell injury.
Academic Article	Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition.
Academic Article	Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
Academic Article	Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox.
Academic Article	Apoptosis and necrosis in the liver: a tale of two deaths?
Academic Article	Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone.
Academic Article	Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply.
Academic Article	Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Academic Article	Toxic injury from mercuric chloride in rat hepatocytes.
Academic Article	Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways.
Academic Article	NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small-for-size rat liver grafts.
Academic Article	Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism.
Academic Article	Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Academic Article	Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species.
Academic Article	Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition.
Academic Article	NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice.
Academic Article	UCPs--unlikely calcium porters.
Academic Article	A new method to monitor Kupffer-cell function continuously in the perfused rat liver. Dissociation of glycogenolysis from particle phagocytosis.
Academic Article	Is there release of mitochondrial calcium in toxic injury?
Academic Article	Mitochondrial calcium and the permeability transition in cell death.
Academic Article	c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
Academic Article	The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.
Academic Article	Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats.
Academic Article	Inhibition of the mitochondrial permeability transition by protein kinase A in rat liver mitochondria and hepatocytes.
Academic Article	NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy.
Academic Article	Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Academic Article	Elevated levels of endothelin-1 in hepatic venous blood are associated with intrapulmonary vasodilatation in humans.
Academic Article	Autophagy in alcohol-induced liver diseases.
Academic Article	Evidence that graft survival is not related to parenchymal cell viability in rat liver transplantation. The importance of nonparenchymal cells.
Academic Article	Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers.
Academic Article	Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811.
Academic Article	Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice.
Academic Article	Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation.
Academic Article	C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation.
Academic Article	Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after transplantation.
Academic Article	Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
Academic Article	Suramin decreases injury and improves regeneration of ethanol-induced steatotic partial liver grafts.
Academic Article	Ischemia/Reperfusion injury in liver surgery and transplantation.
Academic Article	Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin.
Academic Article	Alkyltin inhibition of ATPase activities in tissue homogenates and subcellular fractions from adult and neonatal rats.
Academic Article	New micro-optical methods to study metabolism in periportal and pericentral regions of the liver lobule.
Academic Article	Calcium dependence of bleb formation and cell death in hepatocytes.
Academic Article	Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers.
Academic Article	Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver: protection by allopurinol.
Academic Article	Fructose prevents hypoxic cell death in liver.
Academic Article	New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state.
Academic Article	Inhibition of ATPase activities of brain and liver homogenates by triethyltin (TET).
Academic Article	Liposome-mitochondrial inner membrane fusion. Lateral diffusion of integral electron transfer components.
Academic Article	Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria.
Academic Article	Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver.
Academic Article	Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment.
Academic Article	Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia.
Academic Article	Rates of alcohol dehydrogenase-dependent ethanol metabolism in periportal and pericentral regions of the perfused rat liver.
Academic Article	Non-equilibrium thermodynamics of oxidative phosphorylation by inverted inner membrane vesicles of rat liver mitochondria.
Academic Article	Near thermodynamic equilibrium of oxidative phosphorylation by inverted inner membrane vesicles of rat liver mitochondria.
Academic Article	Evidence that free radicals are involved in graft failure following orthotopic liver transplantation in the rat--an electron paramagnetic resonance spin trapping study.
Academic Article	Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study.
Academic Article	Reperfusion injury to endothelial cells after cold storage of rat livers: protection by mildly acidic pH and lack of protection by antioxidants.
Academic Article	Glycine in Carolina rinse solution reduces reperfusion injury, improves graft function, and increases graft survival after rat liver transplantation.
Academic Article	ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition.
Academic Article	Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes.
Academic Article	Bacterial cell wall polymers (peptidoglycan-polysaccharide) cause reactivation of arthritis.
Academic Article	Carolina rinse solution decreases liver injury during clinical liver transplantation.
Academic Article	Ultrastructural correlates of liver graft failure from storage injury: studies of graft protection by Carolina rinse solution and pentoxifylline.
Academic Article	Role of sinusoidal lining cells in hepatic reperfusion injury following cold storage and transplantation.
Academic Article	Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.
Academic Article	Down-regulation of HCW9 mRNA in rat hepatocytes during chemical hypoxia involves both transcriptional and posttranscriptional mechanisms.
Academic Article	Role of Kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury.
Academic Article	Dual role of Kupffer cell activation and endothelial cell damage in reperfusion injury to livers stored for transplantation surgery.
Academic Article	Role of free radicals in failure of fatty livers following liver transplantation and alcoholic liver injury.
Academic Article	Contribution of pH-dependent group II phospholipase A2 to chemical hypoxic injury in rat hepatocytes.
Academic Article	Pilot study: Carolina Rinse Solution improves graft function after orthotopic liver transplantation in humans.
Concept	Liver Circulation
Concept	Chemical and Drug Induced Liver Injury, Chronic
Concept	Liver Regeneration
Concept	Liver Function Tests
Concept	Chemical and Drug Induced Liver Injury
Concept	Liver Cirrhosis, Experimental
Concept	Liver Diseases, Alcoholic
Concept	Fatty Liver, Alcoholic
Concept	Liver Glycogen
Concept	Mitochondria, Liver
Concept	Liver Neoplasms
Concept	Liver Diseases
Concept	Liver Cirrhosis
Concept	Liver
Concept	Liver Transplantation
Concept	Liver Failure
Concept	Fatty Liver
Academic Article	Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter.
Academic Article	Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism.
Academic Article	Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation.
Academic Article	Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43.
Award or Honor Receipt	Inaugural Fellow
Award or Honor Receipt	Councillor-at-Large
Academic Article	ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator.
Academic Article	Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline.
Academic Article	The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice.
Academic Article	Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
Academic Article	Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats.
Academic Article	Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice.
Academic Article	Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice.
Academic Article	Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria.
Academic Article	2',3'-Cyclic nucleotide 3'-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging.
Academic Article	Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria.
Academic Article	8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation.
Academic Article	Ischemic preconditioning attenuates acute lung injury after partial liver transplantation.
Academic Article	A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease.
Academic Article	Mitophagy in hepatocytes: Types, initiators and role in adaptive ethanol metabolism?.
Academic Article	Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice.
Academic Article	JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells.
Academic Article	Iron loss triggers mitophagy through induction of mitochondrial ferritin.
Academic Article	Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline.
Academic Article	Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization.
Academic Article	The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Academic Article	Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice.
Academic Article	Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice.

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