Item Type | Name |
Academic Article
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ERAB contains a putative noncleavable signal peptide.
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Academic Article
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Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
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Academic Article
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A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
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Academic Article
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Characterization of recombinant, soluble beta-secretase from an insect cell expression system.
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Academic Article
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The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
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Academic Article
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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
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Academic Article
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The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease.
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Academic Article
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17beta-estradiol reduces plasma Abeta40 for HRT-na?ve postmenopausal women with Alzheimer disease: a preliminary study.
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Academic Article
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New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.
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Academic Article
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
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Academic Article
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Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
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Academic Article
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Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.
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Academic Article
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The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.
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Academic Article
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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
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Academic Article
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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.
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Academic Article
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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
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Academic Article
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Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.
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Academic Article
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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
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Academic Article
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Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.
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Academic Article
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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
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Academic Article
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Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
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Academic Article
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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
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Academic Article
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Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?
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Academic Article
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Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors.
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Academic Article
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An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice.
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Academic Article
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GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.
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Academic Article
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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
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Concept
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Peptide Fragments
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Concept
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Receptors, Formyl Peptide
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Concept
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Peptide Hydrolases
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Concept
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Glucagon-Like Peptide 1
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Academic Article
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Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury.
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Academic Article
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Resolution of inflammation is altered in Alzheimer's disease.
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Concept
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Glucagon-Like Peptide-1 Receptor
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