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One or more keywords matched the following properties of Woster, Patrick
keywords histone demethylase
keywords histone deacetylase
overview Dr. Patrick M. Woster received a B.S. degree in Pharmacy in 1978 and a Ph.D. in medicinal chemistry in 1986, both from the University of Nebraska. He completed postdoctoral work in the laboratory of James Coward at Rensselaer Polytechnic Institute (chemistry) and the University of Michigan (medicinal chemistry), and then joined the faculty at Wayne State University as an assistant professor in 1988. He was promoted to Professor of Pharmaceutical Sciences in 2000. Dr. Woster moved to the Medical University of South Carolina in 2011, where he is Professor, Interim Chair of Drug Discovery and Biomedical Sciences and the South Carolina SmartStateā„¢ Endowed Chair in Drug Discovery (2011-present). He also serves as Director of the MUSC Drug Design and Synthesis Core. Professor Woster maintains an active research program that has been funded by NIH, WHO and the pharmaceutical industry. Ongoing projects in the Woster laboratories include the synthesis of novel inhibitors of lysine-specific demethylase 1 and histone deacetylases as epigenetic modulators, synthesis of oligoamines as antitumor, antibacterial or antimalarial agents, design and synthesis of small molecules and cyclic/stapled peptide analogues as epigenetic modulators and the synthesis of mechanism-based enzyme inactivators. Dr. Woster has directed 12 Ph.D. dissertations and 4 Master's theses, and has mentored 11 postdoctoral associates. To date, he has authored more than 120 articles in peer-reviewed research journals, 120 research abstracts and 15 patent applications. He is a frequent invited speaker, both nationally and internationally, and has organized a number of scientific conferences, including the 2009 Gordon Research Conference and Graduate Research Seminar on Polyamines, and the 34th National Medicinal Chemistry Symposium. Dr. Woster has served as a member of many NIH study sections and other grant review panels, and serves on editorial boards or as a reviewer for numerous scientific journals. He has also been an active member of American Chemical Society (ACS), and has served as an officer in the Division of Medicinal Chemistry for 21 years.
One or more keywords matched the following items that are connected to Woster, Patrick
Item TypeName
Academic Article Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.
Academic Article Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes.
Academic Article Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.
Academic Article Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
Academic Article Use of polyamine derivatives as selective histone deacetylase inhibitors.
Academic Article Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells.
Academic Article Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
Academic Article Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.
Academic Article Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Academic Article Recent advances in the development of polyamine analogues as antitumor agents.
Academic Article Design of polyamine-based therapeutic agents: new targets and new directions.
Academic Article Polyamine analogues targeting epigenetic gene regulation.
Academic Article A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells.
Academic Article (Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.
Concept Jumonji Domain-Containing Histone Demethylases
Concept Histone Deacetylases
Concept Histone Demethylases
Concept Histone Deacetylase Inhibitors
Concept Histone Acetyltransferases
Concept Histones
Concept Histone-Lysine N-Methyltransferase
Academic Article Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.
Academic Article Design of small molecule epigenetic modulators.
Academic Article The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.
Academic Article Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.
Academic Article Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.
Academic Article Transcriptional activity of the islet ? cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Academic Article Epigenetics: novel therapeutics targeting epigenetics.
Academic Article Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.
Academic Article Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis.
Academic Article Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma.
Academic Article New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.
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  • Histones