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keywords
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histone demethylase
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keywords
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histone deacetylase
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overview
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Dr. Patrick M. Woster received a B.S. degree in Pharmacy in 1978 and a Ph.D. in medicinal chemistry in 1986, both from the University of Nebraska. He completed postdoctoral work in the laboratory of James Coward at Rensselaer Polytechnic Institute (chemistry) and the University of Michigan (medicinal chemistry), and then joined the faculty at Wayne State University as an assistant professor in 1988. He was promoted to Professor of Pharmaceutical Sciences in 2000. Dr. Woster moved to the Medical University of South Carolina in 2011, where he is Professor, Interim Chair of Drug Discovery and Biomedical Sciences and the South Carolina SmartState™ Endowed Chair in Drug Discovery (2011-present). He also serves as Director of the MUSC Drug Design and Synthesis Core. Professor Woster maintains an active research program that has been funded by NIH, WHO and the pharmaceutical industry. Ongoing projects in the Woster laboratories include the synthesis of novel inhibitors of lysine-specific demethylase 1 and histone deacetylases as epigenetic modulators, synthesis of oligoamines as antitumor, antibacterial or antimalarial agents, design and synthesis of small molecules and cyclic/stapled peptide analogues as epigenetic modulators and the synthesis of mechanism-based enzyme inactivators. Dr. Woster has directed 12 Ph.D. dissertations and 4 Master's theses, and has mentored 11 postdoctoral associates. To date, he has authored more than 120 articles in peer-reviewed research journals, 120 research abstracts and 15 patent applications. He is a frequent invited speaker, both nationally and internationally, and has organized a number of scientific conferences, including the 2009 Gordon Research Conference and Graduate Research Seminar on Polyamines, and the 34th National Medicinal Chemistry Symposium. Dr. Woster has served as a member of many NIH study sections and other grant review panels, and serves on editorial boards or as a reviewer for numerous scientific journals. He has also been an active member of American Chemical Society (ACS), and has served as an officer in the Division of Medicinal Chemistry for 21 years.
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