"Histone Demethylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyse the removal of methyl groups from LYSINE or ARGININE residues found on HISTONES. Many histone demethylases generally function through an oxidoreductive mechanism.
| Descriptor ID |
D056466
|
| MeSH Number(s) |
D08.811.682.662.582.475
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Histone Demethylases".
Below are MeSH descriptors whose meaning is more specific than "Histone Demethylases".
This graph shows the total number of publications written about "Histone Demethylases" by people in this website by year, and whether "Histone Demethylases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 3 | 0 | 3 |
| 2015 | 3 | 0 | 3 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 1 | 3 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histone Demethylases" by people in Profiles.
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Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. Eur J Med Chem. 2022 Dec 15; 244:114818.
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It is a complex issue: emerging connections between epigenetic regulators in drug addiction. Eur J Neurosci. 2019 08; 50(3):2477-2491.
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Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5):557-572.
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Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. Eur J Med Chem. 2018 Mar 25; 148:210-220.
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Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model. Proteins. 2016 12; 84(12):1797-1809.
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Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease. Int J Mol Sci. 2015 Nov 13; 16(11):27270-87.
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Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity. Hum Mol Genet. 2015 May 15; 24(10):2861-72.
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Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorg Med Chem. 2015 Apr 01; 23(7):1601-12.
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Design of small molecule epigenetic modulators. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):21-32.
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The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Amino Acids. 2014 Mar; 46(3):585-94.