Andrew James Goodwin

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 630
Clinical Science Bldg. - 96 Jonathan Lucas St.
Phone843-792-4728
Fax843-876-2057
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    Collapse Biography 
    Collapse awards and honors
    2011 - 2011Hermansky Pudlak Syndrome Travel Award, American Thoracic Society
    2013 - 2015KL2 Scholars Program, Medical University of South Carolina
    2014 - 2016Loan Repayment Program, National Institutes of Health-NHLBI

    Collapse Overview 
    Collapse overview
    I am a pulmonary intensivist dedicated to providing high quality critical care and performing clinical and translational research on critical illness. My research interests include the translational study of endothelial dysfunction in sepsis and ARDS as well as the clinical study of ICU structures and processes and how they influence critical illness outcomes.
    Collapse keywords
    Inflammation, Ethnicity and Disease, Minorities, Genetics

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frisch NK, Gibson PC, Stowman AM, Goodwin A, Schwartz M, Cortright V, Hong T, Kalof A. Anatomy of a Cyberattack: Part 4: Quality Assurance and Error Reduction, Billing and Compliance, Transition to Uptime. Am J Clin Pathol. 2022 07 01; 158(1):18-26. PMID: 35188946.
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    2. Goodwin A, Wilburn C, Wojewoda C, Mesec J, Cacciatore LS, Grove SA, Hajder A, Stowman AM. Anatomy of a Cyberattack: Part 2: Managing a Clinical Pathology Laboratory During 25 Days of Downtime. Am J Clin Pathol. 2022 05 04; 157(5):653-663. PMID: 35188951.
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    3. Spiegel MC, Simpson AN, Nadig NR, Ford DW, Goodwin AJ. Clinician attitudes and concordance with self-assessed and actual intravenous fluid prescribing patterns: A single-institution evaluation of survey and electronic prescribing data. Am J Med Sci. 2022 07; 364(1):36-45. PMID: 35385710.
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    4. Wu Y, Li P, Liu L, Goodwin AJ, Halushka PV, Hirose T, Nakagawa S, Zhou J, Liu M, Fan H. lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta. Mol Ther. 2022 07 06; 30(7):2618-2632. PMID: 35331906.
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    5. Peltan ID, Caldwell E, Admon AJ, Attia EF, Gundel SJ, Mathews KS, Nagrebetsky A, Sahetya SK, Ulysse C, Brown SM, Chang SY, Goodwin AJ, Hope AA, Iwashyna TJ, Johnson NJ, Lanspa MJ, Richardson LD, Vranas KC, Angus DC, Baron RM, Haaland BA, Hayden DL, Thompson BT, Rice TW, Hough CL. Characteristics and Outcomes of US Patients Hospitalized With COVID-19. Am J Crit Care. 2022 03 01; 31(2):146-157. PMID: 34709373.
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    6. Nadig NR, Brinton DL, Simpson KN, Goodwin AJ, Simpson AN, Ford DW. The Impact of Timing on Clinical and Economic Outcomes During Inter-ICU Transfer of Acute Respiratory Failure Patients: Time and Tide Wait for No One. Crit Care Explor. 2022 Mar; 4(3):e0642. PMID: 35261978.
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    7. Li P, Wu Y, Hamlett ED, Goodwin AJ, Halushka PV, Carroll SL, Liu M, Fan H. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease. Mol Ther. 2022 04 06; 30(4):1451-1464. PMID: 35038582.
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    8. Volod O, Rollins-Raval M, Goodwin AJ, Higgins RA, Long T, Chandler WL, Harris NS, Pham HP, Isom JA, Moser K, Olson JD, Smock KJ, VanSandt A, Wool G, Chen D. Interlaboratory Performance in Measurement of Dabigatran and Rivaroxaban. Arch Pathol Lab Med. 2022 01 02; 146(2):145-153. PMID: 34133726.
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    9. Goodwin A, Mazwi ML, Somer J, Schwartz SM, McEwan A, Eytan D. Blood Pressure in Critically Ill Children: Exploratory Analyses of Concurrent Invasive and Noninvasive Measurements. Crit Care Explor. 2021 Dec; 3(12):e0586. PMID: 34984339.
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    10. Brinton DL, Ford DW, Martin RH, Simpson KN, Goodwin AJ, Simpson AN. Missing data methods for intensive care unit SOFA scores in electronic health records studies: results from a Monte Carlo simulation. J Comp Eff Res. 2022 01; 11(1):47-56. PMID: 34726477.
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    11. Spiegel MC, Simpson AN, Philip A, Bell CM, Nadig NR, Ford DW, Goodwin AJ. Development and implementation of a clinical decision support-based initiative to drive intravenous fluid prescribing. Int J Med Inform. 2021 12; 156:104619. PMID: 34673308.
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    12. Thomas AA, Wright H, Chan K, Ross H, Prasad P, Goodwin A, Holmes CE. Safety of apixaban for venous thromboembolic primary prophylaxis in patients with newly diagnosed malignant glioma. J Thromb Thrombolysis. 2022 Feb; 53(2):479-484. PMID: 34347201.
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    13. D'Arcy J, Haines K, Paul E, Doherty Z, Goodwin A, Bailey M, Barrett J, Bellomo R, Bucknall T, Gabbe BJ, Higgins AM, Iwashyna TJ, Murray LJ, Myles PS, Ponsford J, Pilcher D, Udy AA, Walker C, Young M, Cooper DJJ, Hodgson CL. The impact of distance on post-ICU disability. Aust Crit Care. 2022 07; 35(4):355-361. PMID: 34321180.
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    14. Warrington JS, Crothers JW, Goodwin A, Coulombe L, Hong T, Bryan L, Wojewoda C, Fung M, Warrington G, Clark V, Risley L, Lewis M. All Hands-On Deck and All Decks on Hand: Surmounting Supply Chain Limitations During the COVID-19 Pandemic. Acad Pathol. 2021 Jan-Dec; 8:23742895211011928. PMID: 34027053.
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    15. Gergi M, Goodwin A, Freeman K, Colovos C, Volod O. Viscoelastic hemostasis assays in septic, critically ill coronavirus disease 2019 patients: a practical guide for clinicians. Blood Coagul Fibrinolysis. 2021 Apr 01; 32(3):225-228. PMID: 33443923.
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    16. Nadig NR, Sterba KR, Simpson AN, Ruggiero KJ, Hough CT, Goodwin AJ, White K, Ford DW. Psychological Outcomes in Family Members of Patients With Acute Respiratory Failure: Does Inter-ICU Transfer Play a Role? Chest. 2021 09; 160(3):890-898. PMID: 33753046.
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    17. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest. 2021 05; 101(5):625-635. PMID: 33446892.
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    18. Sterba KR, Johnson EE, Nadig N, Simpson AN, Simpson KN, Goodwin AJ, Beeks R, Warr EH, Zapka J, Ford DW. Determinants of Evidence-based Practice Uptake in Rural Intensive Care Units. A Mixed Methods Study. Ann Am Thorac Soc. 2020 09; 17(9):1104-1116. PMID: 32421348.
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    19. Wu Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Zingarelli B, Fan H. miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2020 08 17; 222(6):1037-1045. PMID: 32285112.
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    20. Rollins-Raval MA, Marlar RA, Goodwin AJ. Age-Adjusted D-dimer Cutoffs: A Warning From the Laboratory. Ann Emerg Med. 2020 06; 75(6):783-784. PMID: 32471582.
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    21. Moser KA, Pearson LN, Pelt CE, Olson JD, Goodwin AJ, Isom JA, Harris NS, Pham HP, Smock KJ, Unold D, VanSandt AM, Volod O, Chen D. Letter to the Editor on "The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria". J Arthroplasty. 2020 09; 35(9):2682-2683. PMID: 32513614.
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    22. Goodwin AJ, Li P, Halushka PV, Cook JA, Sumal AS, Fan H. Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1261-L1269. PMID: 32321279.
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    23. Goodwin AJ, Eytan D, Greer RW, Mazwi M, Thommandram A, Goodfellow SD, Assadi A, Jegatheeswaran A, Laussen PC. A practical approach to storage and retrieval of high-frequency physiological signals. Physiol Meas. 2020 04 20; 41(3):035008. PMID: 32131060.
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    24. Jani P, Hinder M, Badawi N, Galea C, Goodwin A, Tracy M. Are there changes to regional tissue oxygenation and circulation following umbilical artery catheter placement? A prospective cohort study in newborn infants. J Paediatr Child Health. 2020 Apr; 56(4):550-556. PMID: 31714662.
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    25. Eytan D, Mazwi ML, Goodwin AJ, Goodfellow SD, Assadi A, Greer RW, Jegatheeswaran A, Laussen PC. Revisiting oxygen dissociation curves and bedside measured arterial saturation in critically ill children. Intensive Care Med. 2019 12; 45(12):1832-1834. PMID: 31588982.
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    26. Johnson EE, Sterba KR, Goodwin AJ, Warr EH, Beeks R, Zapka JM, Ford DW. Implementation of an Academic-to-Community Hospital Intensive Care Unit Quality Improvement Program. Qualitative Analysis of Multilevel Facilitators and Barriers. Ann Am Thorac Soc. 2019 07; 16(7):877-885. PMID: 30822096.
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    27. Eytan D, Jegatheeswaran A, Mazwi ML, Assadi A, Goodwin AJ, Greer RW, Goodfellow SD, Laussen PC. Temporal Variability in the Sampling of Vital Sign Data Limits the Accuracy of Patient State Estimation. Pediatr Crit Care Med. 2019 07; 20(7):e333-e341. PMID: 31162373.
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    28. Sarraf E, Mathews DM, Tsai MH, Goodwin AJ. Optimizing the use of point of care testing devices for screening patients. J Clin Monit Comput. 2020 Jun; 34(3):411-419. PMID: 31183771.
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    29. Nadig NR, Sterba KR, Johnson EE, Goodwin AJ, Ford DW. Inter-ICU transfer of patients with ventilator dependent respiratory failure: Qualitative analysis of family and physician perspectives. Patient Educ Couns. 2019 09; 102(9):1703-1710. PMID: 30979579.
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    30. Fan H, Goodwin AJ. What's New in Shock, March 2019? Shock. 2019 03; 51(3):269-272. PMID: 30475330.
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    31. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019 02 13; 23(1):44. PMID: 30760290.
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    32. Li P, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Fan H. Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes. Mol Immunol. 2019 04; 108:1-7. PMID: 30739075.
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    33. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405.
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    34. Goodwin AJ. Are Sepsis Outcomes Predetermined? How the Road toward Sepsis May Predict Outcomes. Ann Am Thorac Soc. 2019 01; 16(1):57-59. PMID: 30592450.
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    35. Goodwin AJ. Can Serial Quick Sequential (Sepsis-Related) Organ Failure Assessment Measurement Aid in Sepsis Identification and Triage Decisions? Crit Care Med. 2018 12; 46(12):2046-2048. PMID: 30444809.
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    36. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2018 11 05; 218(12):1995-2005. PMID: 30053030.
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    37. Salter R, Bailey M, Bellomo R, Eastwood G, Goodwin A, Nielsen N, Pilcher D, Nichol A, Saxena M, Shehabi Y, Young P. Changes in Temperature Management of Cardiac Arrest Patients Following Publication of the Target Temperature Management Trial. Crit Care Med. 2018 11; 46(11):1722-1730. PMID: 30063490.
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    38. Halushka PV, Goodwin AJ, Halushka MK. Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers. Annu Rev Pathol. 2019 01 24; 14:211-238. PMID: 30332561.
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    39. Goodwin AJ. Critical Care Outcomes Among Opioid Users: Hidden Sequelae of a Growing Crisis? Crit Care Med. 2018 06; 46(6):1005-1006. PMID: 29762398.
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    40. Goodwin AJ, Ford DW. Readmissions Among Sepsis Survivors: Risk Factors and Prevention. Clin Pulm Med. 2018 May; 25(3):79-83. PMID: 30237689.
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    41. Ambaye AB, MacLennan SE, Goodwin AJ, Weaver DL. In Reply. Arch Pathol Lab Med. 2018 03; 142(3):287b-288. PMID: 29494221.
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    42. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. PMID: 29599080.
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    43. Eytan D, Goodwin AJ, Greer R, Guerguerian AM, Mazwi M, Laussen PC. Distributions and Behavior of Vital Signs in Critically Ill Children by Admission Diagnosis. Pediatr Crit Care Med. 2018 02; 19(2):115-124. PMID: 29206728.
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    44. Goodwin AJ, Adcock DM. Thrombophilia Testing and Venous Thrombosis. N Engl J Med. 2017 12 07; 377(23):2297-8. PMID: 29215221.
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    45. Ambaye AB, Goodwin AJ, MacLennan SE, Naud S, Weaver DL. Recommendations for Pathologic Evaluation of Reduction Mammoplasty Specimens: A Prospective Study With Systematic Tissue Sampling. Arch Pathol Lab Med. 2017 Nov; 141(11):1523-1528. PMID: 28795842.
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    46. Nadig NR, Goodwin AJ, Simpson AN, Simpson KN, Richards J, Ford DW. Patient and Hospital Characteristics Associated with Interhospital Transfer for Adults with Ventilator-Dependent Respiratory Failure. Ann Am Thorac Soc. 2017 May; 14(5):730-736. PMID: 28199137.
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    47. Eytan D, Goodwin AJ, Greer R, Guerguerian AM, Laussen PC. Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children. Front Pediatr. 2017; 5:52. PMID: 28367430.
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    48. Goodwin AJ, Liu V, Ford DW. Hospital Readmissions in Sepsis Survivors: Are They Preventable? Ann Am Thorac Soc. 2017 02; 14(2):170-171. PMID: 28146387.
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    49. Goodwin AJ, Higgins RA, Moser KA, Smock KJ, Chandler WL, Kottke-Marchant K, Hartman SK, Volod O, Brown AF, Johari VP, Burr S, Polyakov N, Chen D. Issues Surrounding Age-Adjusted d-Dimer Cutoffs That Practicing Physicians Need to Know When Evaluating Patients With Suspected Pulmonary Embolism. Ann Intern Med. 2017 Mar 07; 166(5):361-363. PMID: 28024301.
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    50. Kalivas BC, Goodwin AJ. A Woman in Her 60s With Fever and Altered Mental Status in a Psychiatric Hospital. Chest. 2016 Dec; 150(6):e171-e174. PMID: 27938775.
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    51. Jones Buie JN, Goodwin AJ, Cook JA, Halushka PV, Fan H. The role of miRNAs in cardiovascular disease risk factors. Atherosclerosis. 2016 11; 254:271-281. PMID: 27693002.
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    52. Goodwin AJ, Nadig NR, McElligott JT, Simpson KN, Ford DW. Where You Live Matters: The Impact of Place of Residence on Severe Sepsis Incidence and Mortality. Chest. 2016 Oct; 150(4):829-836. PMID: 27445093.
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    53. Guo C, Goodwin A, Buie JNJ, Cook J, Halushka P, Argraves K, Zingarelli B, Zhang X, Wang L, Fan H. A Stromal Cell-Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Mol Med. 2016 Sep; 22:115-123. PMID: 27031787.
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    54. Ford DW, Goodwin AJ, Simpson AN, Johnson E, Nadig N, Simpson KN. A Severe Sepsis Mortality Prediction Model and Score for Use With Administrative Data. Crit Care Med. 2016 Feb; 44(2):319-27. PMID: 26496452.
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    55. Eytan D, Goodwin A, Laussen P, Guerguerian AM. Insights From Multi-Dimensional Physiological Signals to Predict and Prevent Cardiac Arrests. Pediatr Crit Care Med. 2016 Jan; 17(1):81-2. PMID: 26731319.
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    56. Goodwin AJ, Guo C, Cook JA, Wolf B, Halushka PV, Fan H. Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study. Crit Care. 2015 Dec 18; 19:440. PMID: 26683209.
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    57. Velez JC, Kadian M, Taburyanskaya M, Bohm NM, Delay TA, Karakala N, Rockey DC, Nietert PJ, Goodwin AJ, Whelan TP. Hepatorenal Acute Kidney Injury and the Importance of Raising Mean Arterial Pressure. Nephron. 2015; 131(3):191-201. PMID: 26485256.
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    58. Goodwin AJ, Rice DA, Simpson KN, Ford DW. The authors reply. Crit Care Med. 2015 Oct; 43(10):e461-2. PMID: 26376264.
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    59. Goodwin AJ, Simpson KN, Ford DW. Volume-Mortality Relationships during Hospitalization with Severe Sepsis Exist Only at Low Case Volumes. Ann Am Thorac Soc. 2015 Aug; 12(8):1177-84. PMID: 26086787.
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    60. Persing S, Jerome MA, James TA, Callas P, Mace J, Sowden M, Goodwin A, Weaver DL, Sprague BL. Surgical margin reporting in breast conserving surgery: Does compliance with guidelines affect re-excision and mastectomy rates? Breast. 2015 Oct; 24(5):618-22. PMID: 26199197.
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    61. Akowuah E, Burdett C, Khan K, Goodwin A, Lage IB, El-Saegh M, Smailes T, Hunter S. Early and Late Outcomes After Minimally Invasive Mitral Valve Repair Surgery. J Heart Valve Dis. 2015 Jul; 24(4):470-7. PMID: 26897819.
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    62. Goodwin AJ, Rice DA, Simpson KN, Ford DW. Frequency, cost, and risk factors of readmissions among severe sepsis survivors. Crit Care Med. 2015 Apr; 43(4):738-46. PMID: 25746745.
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    63. Feng S, Weaver DL, Carney PA, Reisch LM, Geller BM, Goodwin A, Rendi MH, Onega T, Allison KH, Tosteson AN, Nelson HD, Longton G, Pepe M, Elmore JG. A framework for evaluating diagnostic discordance in pathology discovered during research studies. Arch Pathol Lab Med. 2014 Jul; 138(7):955-61. PMID: 24978923.
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    64. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. PMID: 24707934.
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    65. Shi Y, Gochuico BR, Yu G, Tang X, Osorio JC, Fernandez IE, Risquez CF, Patel AS, Shi Y, Wathelet MG, Goodwin AJ, Haspel JA, Ryter SW, Billings EM, Kaminski N, Morse D, Rosas IO. Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-ß receptor I internalization and inhibiting transforming growth factor-ß1 signaling. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):831-41. PMID: 23924348.
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    66. Goodwin AJ. Critical care clinical trials: getting off the roller coaster. Chest. 2012 Sep; 142(3):563-567. PMID: 22948575.
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    67. Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic acid-related orphan receptor-a is induced in the setting of DNA damage and promotes pulmonary emphysema. Am J Respir Crit Care Med. 2012 Sep 01; 186(5):412-9. PMID: 22744720.
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    68. Persing S, James TA, Mace J, Goodwin A, Geller B. Variability in the quality of pathology reporting of margin status following breast cancer surgery. Ann Surg Oncol. 2011 Oct; 18(11):3061-5. PMID: 21947586.
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    69. Ambaye AB, MacLennan SE, Goodwin AJ, Suppan T, Naud S, Weaver DL. Carcinoma and atypical hyperplasia in reduction mammaplasty: increased sampling leads to increased detection. A prospective study. Plast Reconstr Surg. 2009 Nov; 124(5):1386-1392. PMID: 20009822.
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    70. Svensson AM, Waters BL, Laszik ZG, Simmons-Arnold L, Goodwin A, Beatty BG, Bovill EG. The protein C system in placental massive perivillous fibrin deposition. Blood Coagul Fibrinolysis. 2004 Sep; 15(6):491-5. PMID: 15311158.
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    71. Goodwin AJ, Rosendaal FR, Kottke-Marchant K, Bovill EG. A review of the technical, diagnostic, and epidemiologic considerations for protein S assays. Arch Pathol Lab Med. 2002 Nov; 126(11):1349-66. PMID: 12421142.
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    72. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 31294331.
      Citations:    
    73. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 30592326.
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