"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
| Descriptor ID |
D035683
|
| MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
|
| Concept/Terms |
MicroRNAs- MicroRNAs
- MicroRNA
- miRNAs
- Micro RNA
- RNA, Micro
- miRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
|
Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 2 | 4 |
| 2009 | 4 | 0 | 4 |
| 2010 | 5 | 1 | 6 |
| 2011 | 9 | 3 | 12 |
| 2012 | 14 | 4 | 18 |
| 2013 | 15 | 6 | 21 |
| 2014 | 25 | 4 | 29 |
| 2015 | 26 | 6 | 32 |
| 2016 | 30 | 5 | 35 |
| 2017 | 17 | 5 | 22 |
| 2018 | 21 | 5 | 26 |
| 2019 | 18 | 7 | 25 |
| 2020 | 18 | 4 | 22 |
| 2021 | 12 | 1 | 13 |
| 2022 | 10 | 1 | 11 |
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click here.
Below are the most recent publications written about "MicroRNAs" by people in Profiles.
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Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and antitumor function. J Clin Invest. 2022 10 03; 132(19).
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miR155 deficiency reduces breast tumor burden in the MMTV-PyMT mouse model. Physiol Genomics. 2022 11 01; 54(11):433-442.
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MicroRNAs and Their Big Therapeutic Impacts: Delivery Strategies for Cancer Intervention. Cells. 2022 07 29; 11(15).
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miR-489 Confines Uncontrolled Estrogen Signaling through a Negative Feedback Mechanism and Regulates Tamoxifen Resistance in Breast Cancer. Int J Mol Sci. 2022 Jul 22; 23(15).
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MicroRNA-31 regulates T-cell metabolism via HIF1a and promotes chronic GVHD pathogenesis in mice. Blood Adv. 2022 05 24; 6(10):3036-3052.
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lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta. Mol Ther. 2022 07 06; 30(7):2618-2632.
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Polymorphism rs3742330 in microRNA Biogenesis Gene DICER1 Is Associated with Pseudoexfoliation Glaucoma in Saudi Cohort. Genes (Basel). 2022 03 10; 13(3).
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Up-Regulated Interleukin-10 Induced by E2F Transcription Factor 2-MicroRNA-17-5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2022 03; 74(3):496-507.
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miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells. Genes (Basel). 2022 01 24; 13(2).
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A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells. BMC Pulm Med. 2022 Jan 07; 22(1):27.