Brett E Froeliger

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
CRI 216
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-6018
Fax843-792-8626
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Dr. Froeliger is a cognitive neuroscientist and the Director of the TRAIN Laboratory. The overarching goal of the TRAIN lab is to use cognitive and affective neuroscience research methods to investigate drug addiction - psychiatric comorbidities. The TRAIN lab conducts studies that examine the neural mechanisms underlying addiction and relapse vulnerability, pharmacotherapies for treating the pathophysiology of addiction and mindfulness-based intervention that promote well-being.
    Collapse keywords
    Breathing, Exercise, Pain, Smoking, Substance Use, Anxiety, Brain, Healthy Volunteer Studies, Mental Health, Nervous System, Physical Therapy, Depression, Environmental Factors, Women-s Health, Central Nervous System, Drug Studies, Men-s Health, Psychiatry, nicotine, opioids, addiction treatment, neuroimaging

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miller MB, Boness CL, DiBello AM, Froeliger B. Insomnia as a moderator of alcohol use and blackout: Potential role in acute physiological consequences. Addict Behav. 2022 Jun 07; 134:107395. PMID: 35696822.
      Citations:    
    2. Garland EL, Hanley AW, Nakamura Y, Barrett JW, Baker AK, Reese SE, Riquino MR, Froeliger B, Donaldson GW. Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial. JAMA Intern Med. 2022 04 01; 182(4):407-417. PMID: 35226053.
      Citations:    
    3. Jones SK, Wolf BJ, Froeliger B, Wallace K, Carpenter MJ, Alberg AJ. Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review. Nicotine Tob Res. 2022 03 26; 24(5):633-642. PMID: 34478556.
      Citations:    
    4. Nall RW, Beloate LN, Meyerink ME, Penaloza T, Doolittle J, Froeliger B, Kalivas PW, Garcia-Keller C. Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. Addict Biol. 2022 03; 27(2):e13151. PMID: 35229943.
      Citations:    
    5. Parisi A, Landicho HL, Hudak J, Leknes S, Froeliger B, Garland EL. Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy. Drug Alcohol Depend. 2022 04 01; 233:109361. PMID: 35278786.
      Citations:    
    6. Hudak J, Bernat EM, Fix ST, Prince KC, Froeliger B, Garland EL. Neurophysiological Deficits During Reappraisal of Negative Emotional Stimuli in Opioid Misuse. Biol Psychiatry. 2022 06 15; 91(12):1070-1078. PMID: 35393080.
      Citations:    
    7. Fisher ML, Pauly JR, Froeliger B, Turner JR. Translational Research in Nicotine Addiction. Cold Spring Harb Perspect Med. 2021 06 01; 11(6). PMID: 32513669.
      Citations:    
    8. Carpenter MJ, Gray KM, Wahlquist AE, Cropsey K, Saladin ME, Froeliger B, Smith TT, Toll BA, Dahne J. A Pilot Randomized Clinical Trial of Remote Varenicline Sampling to Promote Treatment Engagement and Smoking Cessation. Nicotine Tob Res. 2021 05 24; 23(6):983-991. PMID: 33249458.
      Citations:    
    9. Bell S, Froeliger B. Associations Between Smoking Abstinence, Inhibitory Control, and Smoking Behavior: An fMRI Study. Front Psychiatry. 2021; 12:592443. PMID: 33868037.
      Citations:    
    10. Cole CA, Powers S, Tomko RL, Froeliger B, Valafar H. Quantification of Smoking Characteristics Using Smartwatch Technology: Pilot Feasibility Study of New Technology. JMIR Form Res. 2021 Feb 05; 5(2):e20464. PMID: 33544083.
      Citations:    
    11. Halbert CH, Jefferson MS, Danielson C, Froeliger B, Giordano A, Thaxton JE. An observational study and randomized trial of stress reactivity in cancer disparities. Health Psychol. 2020 Sep; 39(9):745-757. PMID: 32833476.
      Citations:    
    12. Hudak J, Prince KC, Marchand WR, Nakamura Y, Hanley AW, Bryan CJ, Froeliger B, Garland EL. The temporal dynamics of emotion dysregulation in prescription opioid misuse. Prog Neuropsychopharmacol Biol Psychiatry. 2021 01 10; 104:110024. PMID: 32589895.
      Citations:    
    13. Newman-Norlund RD, Gibson M, McConnell PA, Froeliger B. Dissociable Effects of Theta-Burst Repeated Transcranial Magnetic Stimulation to the Inferior Frontal Gyrus on Inhibitory Control in Nicotine Addiction. Front Psychiatry. 2020; 11:260. PMID: 32351412.
      Citations:    
    14. Garland EL, Atchley RM, Hanley AW, Zubieta JK, Froeliger B. Mindfulness-Oriented Recovery Enhancement remediates hedonic dysregulation in opioid users: Neural and affective evidence of target engagement. Sci Adv. 2019 10; 5(10):eaax1569. PMID: 31663023.
      Citations:    
    15. Garland EL, Bryan MA, Priddy SE, Riquino MR, Froeliger B, Howard MO. Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study. Ann Behav Med. 2019 08 29; 53(10):865-876. PMID: 30668631.
      Citations:    
    16. Tomko RL, McClure EA, Cato PA, Wang JB, Carpenter MJ, Karelitz JL, Froeliger B, Saladin ME, Gray KM. An electronic, smart lighter to measure cigarette smoking: A pilot study to assess feasibility and initial validity. Addict Behav. 2019 11; 98:106052. PMID: 31415971.
      Citations:    
    17. McConnell PA, Garland EL, Zubieta JK, Newman-Norlund R, Powers S, Froeliger B. Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect. Addict Biol. 2020 03; 25(2):e12743. PMID: 30945801.
      Citations:    
    18. Mathew AR, Heckman BW, Froeliger B, Saladin ME, Brown RA, Hitsman B, Carpenter MJ. Multi-method assessment of distress tolerance and smoking-related factors among adult daily smokers. Exp Clin Psychopharmacol. 2019 Apr; 27(2):136-145. PMID: 30589279.
      Citations:    
    19. Fridriksson JF, Rorden C, Newman-Norlund RD, Froeliger B, Thrasher JF. Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) From Cigarette Packages. Front Psychiatry. 2018; 9:319. PMID: 30072925.
      Citations:    
    20. Garland EL, Hanley AW, Bedford CE, Zubieta JK, Howard MO, Nakamura Y, Donaldson GW, Froeliger B. Reappraisal deficits promote craving and emotional distress among chronic pain patients at risk for prescription opioid misuse. J Addict Dis. 2018 Jan-Jun; 37(1-2):14-22. PMID: 29863439.
      Citations:    
    21. Garland EL, Bryan CJ, Kreighbaum L, Nakamura Y, Howard MO, Froeliger B. Prescription opioid misusing chronic pain patients exhibit dysregulated context-dependent associations: Investigating associative learning in addiction with the cue-primed reactivity task. Drug Alcohol Depend. 2018 06 01; 187:13-21. PMID: 29626741.
      Citations:    
    22. Carpenter MJ, Heckman BW, Wahlquist AE, Wagener TL, Goniewicz ML, Gray KM, Froeliger B, Cummings KM. A Naturalistic, Randomized Pilot Trial of E-Cigarettes: Uptake, Exposure, and Behavioral Effects. Cancer Epidemiol Biomarkers Prev. 2017 12; 26(12):1795-1803. PMID: 29127080.
      Citations:    
    23. Serfaty S, Gale G, Beadman M, Froeliger B, Kamboj SK. Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies. Mindfulness (N Y). 2018; 9(1):44-58. PMID: 29387264.
      Citations:    
    24. Froeliger B, McConnell PA, Bell S, Sweitzer M, Kozink RV, Eichberg C, Hallyburton M, Kaiser N, Gray KM, McClernon FJ. Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. JAMA Psychiatry. 2017 04 01; 74(4):379-386. PMID: 28249070.
      Citations:    
    25. Germeroth LJ, Carpenter MJ, Baker NL, Froeliger B, LaRowe SD, Saladin ME. Effect of a Brief Memory Updating Intervention on Smoking Behavior: A Randomized Clinical Trial. JAMA Psychiatry. 2017 Mar 01; 74(3):214-223. PMID: 28146243.
      Citations:    
    26. Garland EL, Howard MO, Zubieta JK, Froeliger B. Restructuring Hedonic Dysregulation in Chronic Pain and Prescription Opioid Misuse: Effects of Mindfulness-Oriented Recovery Enhancement on Responsiveness to Drug Cues and Natural Rewards. Psychother Psychosom. 2017; 86(2):111-112. PMID: 28183077.
      Citations:    
    27. Garland EL, Bryan CJ, Nakamura Y, Froeliger B, Howard MO. Deficits in autonomic indices of emotion regulation and reward processing associated with prescription opioid use and misuse. Psychopharmacology (Berl). 2017 Feb; 234(4):621-629. PMID: 27933366.
      Citations:    
    28. Badran BW, Austelle CW, Smith NR, Glusman CE, Froeliger B, Garland EL, Borckardt JJ, George MS, Short B. A Double-Blind Study Exploring the Use of Transcranial Direct Current Stimulation (tDCS) to Potentially Enhance Mindfulness Meditation (E-Meditation). Brain Stimul. 2017 Jan - Feb; 10(1):152-154. PMID: 27839723.
      Citations:    
    29. Meier E, Wahlquist AE, Heckman BW, Cummings KM, Froeliger B, Carpenter MJ. A Pilot Randomized Crossover Trial of Electronic Cigarette Sampling Among Smokers. Nicotine Tob Res. 2017 Feb; 19(2):176-182. PMID: 27613880.
      Citations:    
    30. Osman A, Thrasher JF, Cayir E, Hardin JW, Perez-Hernandez R, Froeliger B. Depressive symptoms and responses to cigarette pack warning labels among Mexican smokers. Health Psychol. 2016 May; 35(5):442-53. PMID: 26867043.
      Citations:    
    31. McConnell PA, Froeliger B. Mindfulness, Mechanisms and Meaning: Perspectives from the Cognitive Neuroscience of Addiction. Psychol Inq. 2015; 26(4):349-357. PMID: 26924915.
      Citations:    
    32. Froeliger B, McConnell PA, Stankeviciute N, McClure EA, Kalivas PW, Gray KM. The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. Drug Alcohol Depend. 2015 Nov 01; 156:234-242. PMID: 26454838.
      Citations:    
    33. Cortese BM, McConnell PA, Froeliger B, Leslie K, Uhde TW. Burning odor-elicited anxiety in OEF/OIF combat veterans: Inverse relationship to gray matter volume in olfactory cortex. J Psychiatr Res. 2015 Nov; 70:58-66. PMID: 26424424.
      Citations:    
    34. Heckman BW, Carpenter MJ, Correa JB, Wray JM, Saladin ME, Froeliger B, Drobes DJ, Brandon TH. Effects of experimental negative affect manipulations on ad libitum smoking: a meta-analysis. Addiction. 2015 May; 110(5):751-60. PMID: 25641624.
      Citations:    
    35. McClernon FJ, Froeliger B, Rose JE, Kozink RV, Addicott MA, Sweitzer MM, Westman EC, Van Wert DM. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addict Biol. 2016 07; 21(4):954-61. PMID: 25904425.
      Citations:    
    36. Addicott MA, Sweitzer MM, Froeliger B, Rose JE, McClernon FJ. Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. Neuropsychopharmacology. 2015 Oct; 40(11):2648-56. PMID: 25895453.
      Citations:    
    37. Garland EL, Hanley A, Farb NA, Froeliger BE. State Mindfulness During Meditation Predicts Enhanced Cognitive Reappraisal. Mindfulness (N Y). 2015 Apr 01; 6(2):234-242. PMID: 26085851.
      Citations:    
    38. Mathew AR, Burris JL, Froeliger B, Saladin ME, Carpenter MJ. Impulsivity and cigarette craving among adolescent daily and occasional smokers. Addict Behav. 2015 Jun; 45:134-8. PMID: 25665916.
      Citations:    
    39. Garland EL, Froeliger B, Howard MO. Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence. Biol Psychol. 2015 Feb; 105:124-9. PMID: 25603284.
      Citations:    
    40. Newman-Norlund RD, Thrasher JF, Fridriksson J, Brixius W, Froeliger B, Hammond D, Cummings MK. Neural biomarkers for assessing different types of imagery in pictorial health warning labels for cigarette packaging: a cross-sectional study. BMJ Open. 2014 Dec 31; 4(12):e006411. PMID: 25552613.
      Citations:    
    41. McConnell PA, Froeliger B, Garland EL, Ives JC, Sforzo GA. Auditory driving of the autonomic nervous system: Listening to theta-frequency binaural beats post-exercise increases parasympathetic activation and sympathetic withdrawal. Front Psychol. 2014; 5:1248. PMID: 25452734.
      Citations:    
    42. Garland EL, Froeliger B, Howard MO. Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT. J Behav Med. 2015 Apr; 38(2):327-36. PMID: 25385024.
      Citations:    
    43. Addicott MA, Pearson JM, Froeliger B, Platt ML, McClernon FJ. Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. Psychiatry Res. 2014 Dec 30; 224(3):254-61. PMID: 25453166.
      Citations:    
    44. McClure EA, Baker NL, Gipson CD, Carpenter MJ, Roper AP, Froeliger BE, Kalivas PW, Gray KM. An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. Am J Drug Alcohol Abuse. 2015 Jan; 41(1):52-6. PMID: 25062287.
      Citations:    
    45. Addicott MA, Froeliger B, Kozink RV, Van Wert DM, Westman EC, Rose JE, McClernon FJ. Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. 2014 Nov; 39(12):2750-9. PMID: 24820539.
      Citations:    
    46. Garland EL, Froeliger B, Howard MO. Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology (Berl). 2014 Aug; 231(16):3229-38. PMID: 24595503.
      Citations:    
    47. Garland EL, Manusov EG, Froeliger B, Kelly A, Williams JM, Howard MO. Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: results from an early-stage randomized controlled trial. J Consult Clin Psychol. 2014 Jun; 82(3):448-459. PMID: 24491075.
      Citations:    
    48. Garland EL, Froeliger B, Howard MO. Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Front Psychiatry. 2014 Jan 10; 4:173. PMID: 24454293.
      Citations:    
    49. Garland EL, Froeliger B, Zeidan F, Partin K, Howard MO. The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways. Neurosci Biobehav Rev. 2013 Dec; 37(10 Pt 2):2597-607. PMID: 23988582.
      Citations:    
    50. Froeliger B, Garland EL, McClernon FJ. Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: results of a preliminary voxel-based morphometric analysis. Evid Based Complement Alternat Med. 2012; 2012:821307. PMID: 23304217.
      Citations:    
    51. Froeliger B, Modlin LA, Kozink RV, Wang L, Garland EL, Addicott MA, McClernon FJ. Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition. Psychiatry Res. 2013 Jan 30; 211(1):57-63. PMID: 23154092.
      Citations:    
    52. Felder JN, Smoski MJ, Kozink RV, Froeliger B, McClernon J, Bizzell J, Petty C, Dichter GS. Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study. BMC Psychiatry. 2012 Sep 21; 12:152. PMID: 22998631.
      Citations:    
    53. Garland EL, Froeliger BE, Passik SD, Howard MO. Attentional bias for prescription opioid cues among opioid dependent chronic pain patients. J Behav Med. 2013 Dec; 36(6):611-20. PMID: 22968666.
      Citations:    
    54. Froeliger BE, Garland EL, Modlin LA, McClernon FJ. Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study. Front Integr Neurosci. 2012; 6:48. PMID: 22855674.
      Citations:    
    55. Froeliger B, Crowell Beckham J, Feldman Dennis M, Victoria Kozink R, Joseph McClernon F. Effects of Nicotine on Emotional Reactivity in PTSD and Non-PTSD Smokers: Results of a Pilot fMRI Study. Adv Pharmacol Sci. 2012; 2012:265724. PMID: 22719754.
      Citations:    
    56. Froeliger B, Garland EL, Kozink RV, Modlin LA, Chen NK, McClernon FJ, Greeson JM, Sobin P. Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond. Evid Based Complement Alternat Med. 2012; 2012:680407. PMID: 22536289.
      Citations:    
    57. Froeliger B, Modlin LA, Kozink RV, Wang L, McClernon FJ. Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing. Addict Biol. 2012 May; 17(3):668-79. PMID: 22081878.
      Citations:    
    58. Froeliger B, Modlin L, Wang L, Kozink RV, McClernon FJ. Nicotine withdrawal modulates frontal brain function during an affective Stroop task. Psychopharmacology (Berl). 2012 Apr; 220(4):707-18. PMID: 21989805.
      Citations:    
    59. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-799. PMID: 21762878.
      Citations:    
    60. Kozink RV, Lutz AM, Rose JE, Froeliger B, McClernon FJ. Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addict Biol. 2010 Oct; 15(4):480-90. PMID: 21040240.
      Citations:    
    61. Froeliger B, Kozink RV, Rose JE, Behm FM, Salley AN, McClernon FJ. Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis. Psychopharmacology (Berl). 2010 Jul; 210(4):577-83. PMID: 20424827.
      Citations:    
    62. Froeliger B, Gilbert DG, McClernon FJ. Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers. Psychopharmacology (Berl). 2009 Sep; 205(4):625-33. PMID: 19488741.
      Citations:    
    63. Carlson JM, Gilbert DG, Riise H, Rabinovich NE, Sugai C, Froeliger B. Serotonin transporter genotype and depressive symptoms moderate effects of nicotine on spatial working memory. Exp Clin Psychopharmacol. 2009 Jun; 17(3):173-80. PMID: 19586232.
      Citations:    
    64. Gilbert DG, Carlson JM, Riise H, Rabinovich NE, Sugai C, Froeliger B. Effects of nicotine and depressive traits on affective priming of lateralized emotional word identification. Exp Clin Psychopharmacol. 2008 Aug; 16(4):293-300. PMID: 18729683.
      Citations:    
    65. Gilbert DG, Sugai C, Zuo Y, Rabinovich NE, McClernon FJ, Froeliger B. Brain indices of nicotine's effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine Tob Res. 2007 Mar; 9(3):351-63. PMID: 17365767.
      Citations:    
    66. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 23146252.
      Citations:    
    67. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 24412684.
      Citations:    
    68. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 31556669.
      Citations:    
    Froeliger's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (176)
    Explore
    _
    Co-Authors (26)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _