Narayan R. Bhat

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
CRI 407
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-7593
Fax843-792-4423
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gopalakrishna R, Lin CY, Oh A, Le C, Yang S, Hicks A, Kindy MS, Mack WJ, Bhat NR. cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-? uptake and amyloid-?-induced neuronal cell death. FEBS Lett. 2022 11; 596(22):2914-2927. PMID: 35971617; PMCID: PMC9712173.
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    2. Watson AN, Berthiaume AA, Faino AV, McDowell KP, Bhat NR, Hartmann DA, Shih AY, Watson AN, Berthiaume AA, Faino AV, McDowell KP, Bhat NR, Hartmann DA, Shih AY. Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFR?+/- mice. J Cereb Blood Flow Metab. 2020 12; 40(12):2387-2400. PMID: 31987006; PMCID: PMC7820684.
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    3. Berthiaume AA, Hartmann DA, Majesky MW, Bhat NR, Shih AY, Berthiaume AA, Hartmann DA, Majesky MW, Bhat NR, Shih AY. Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis. Front Aging Neurosci. 2018; 10:210. PMID: 30065645; PMCID: PMC6057109.
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    4. Berthiaume AA, Grant RI, McDowell KP, Underly RG, Hartmann DA, Levy M, Bhat NR, Shih AY, Berthiaume AA, Grant RI, McDowell KP, Underly RG, Hartmann DA, Levy M, Bhat NR, Shih AY. Dynamic Remodeling of Pericytes In?Vivo Maintains Capillary Coverage in the Adult Mouse Brain. Cell Rep. 2018 01 02; 22(1):8-16. PMID: 29298435; PMCID: PMC5782812.
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    5. Grant RI, Hartmann DA, Underly RG, Berthiaume AA, Bhat NR, Shih AY, Grant RI, Hartmann DA, Underly RG, Berthiaume AA, Bhat NR, Shih AY. Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex. J Cereb Blood Flow Metab. 2019 03; 39(3):411-425. PMID: 28933255; PMCID: PMC6399730.
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    6. Podbielska M, Szulc ZM, Kurowska E, Hogan EL, Bielawski J, Bielawska A, Bhat NR, Podbielska M, Szulc ZM, Kurowska E, Hogan EL, Bielawski J, Bielawska A, Bhat NR. Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line. J Lipid Res. 2016 11; 57(11):2028-2039. PMID: 27623848; PMCID: PMC5087870.
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    7. Pelluru D, Konadhode RR, Bhat NR, Shiromani PJ, Pelluru D, Konadhode RR, Bhat NR, Shiromani PJ. Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice. Eur J Neurosci. 2016 05; 43(10):1298-306. PMID: 26369866; PMCID: PMC4792792.
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    8. Bhat NR, Bhat NR. Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions. J Alzheimers Dis. 2015; 46(3):581-91. PMID: 26402511; PMCID: PMC4582431.
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    9. Hirschhorn J, Mohanty S, Bhat NR, Hirschhorn J, Mohanty S, Bhat NR. The role of tumor progression locus 2 protein kinase in glial inflammatory response. J Neurochem. 2014 Mar; 128(6):919-26. PMID: 24188160; PMCID: PMC3951670.
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    10. Wang R, Li JJ, Diao S, Kwak YD, Liu L, Zhi L, Büeler H, Bhat NR, Williams RW, Park EA, Liao FF, Wang R, Li JJ, Diao S, Kwak YD, Liu L, Zhi L, B?eler H, Bhat NR, Williams RW, Park EA, Liao FF. Metabolic stress modulates Alzheimer's ?-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons. Cell Metab. 2013 May 07; 17(5):685-94. PMID: 23663737; PMCID: PMC5396538.
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    11. Bhat NR, Thirumangalakudi L, Bhat NR, Thirumangalakudi L. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. J Alzheimers Dis. 2013; 36(4):781-9. PMID: 23703152; PMCID: PMC4445975.
      Citations:    
    12. Li X, Liu X, Cui L, Brunson C, Zhao W, Bhat NR, Zhang N, Wen X, Li X, Liu X, Cui L, Brunson C, Zhao W, Bhat NR, Zhang N, Wen X. Engineering an in situ crosslinkable hydrogel for enhanced remyelination. FASEB J. 2013 Mar; 27(3):1127-36. PMID: 23239823; PMCID: PMC3574280.
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    13. Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA, Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from ?-secretase inhibitors. J Neurochem. 2011 May; 117(3):359-74. PMID: 21320126; PMCID: PMC3076515.
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    14. Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS, Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of A?PP transgenic mice. J Alzheimers Dis. 2011; 25(2):295-307. PMID: 21422528; PMCID: PMC5886011.
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    15. Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA, Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol. 2011 May; 21(3):330-48. PMID: 20969653; PMCID: PMC3042034.
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    16. Bhat NR, Bhat NR. Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators. J Neurochem. 2010 Nov; 115(3):551-62. PMID: 20807313; PMCID: PMC2970712.
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    17. Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S, MGC Project Team, Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S. The completion of the Mammalian Gene Collection (MGC). Genome Res. 2009 Dec; 19(12):2324-33. PMID: 19767417; PMCID: PMC2792178.
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    18. Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR, Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85. PMID: 18410513; PMCID: PMC3897170.
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    19. Dasgupta S, Bhat NR, Spicer SS, Hogan EL, Furuya S, Hirabayashi Y, Dasgupta S, Bhat NR, Spicer SS, Hogan EL, Furuya S, Hirabayashi Y. Cell-specific expression of neutral glycosphingolipids in vertebrate brain: immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes. J Neurosci Res. 2007 Oct; 85(13):2856-62. PMID: 17638300.
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    20. Guo G, Bhat NR, Guo G, Bhat NR. p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. Neurochem Res. 2007 Dec; 32(12):2160-6. PMID: 17594516.
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    21. Bhat NR, Zhang P, Mohanty SB, Bhat NR, Zhang P, Mohanty SB. p38 MAP kinase regulation of oligodendrocyte differentiation with CREB as a potential target. Neurochem Res. 2007 Feb; 32(2):293-302. PMID: 17235686.
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    22. Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H, Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006 Dec; 47(12):2772-80. PMID: 16998236.
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    23. Quintero EM, Willis L, Singleton R, Harris N, Huang P, Bhat N, Granholm AC, Quintero EM, Willis L, Singleton R, Harris N, Huang P, Bhat N, Granholm AC. Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease. Brain Res. 2006 Jun 06; 1093(1):198-207. PMID: 16712819.
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    24. Guo G, Bhat NR, Guo G, Bhat NR. Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):911-8. PMID: 16771681.
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    25. Bhat NR, Feinstein DL, Bhat NR, Feinstein DL. NO and glial cell biology. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):869-72. PMID: 16771676.
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    26. Pawate S, Bhat NR, Pawate S, Bhat NR. C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):903-9. PMID: 16771680.
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    27. Shen Q, Zhang R, Bhat NR, Shen Q, Zhang R, Bhat NR. MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells. Brain Res. 2006 May 01; 1086(1):9-16. PMID: 16635481.
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    28. Samuvel DJ, Jayanthi LD, Bhat NR, Ramamoorthy S, Samuvel DJ, Jayanthi LD, Bhat NR, Ramamoorthy S. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci. 2005 Jan 05; 25(1):29-41. PMID: 15634764; PMCID: PMC6725216.
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    29. Pawate S, Shen Q, Fan F, Bhat NR, Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res. 2004 Aug 15; 77(4):540-51. PMID: 15264224.
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    30. Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE, Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004 Aug; 5(6):517-28. PMID: 15270198.
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    31. Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC, Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci. 2004 Jun; 19(12):3305-16. PMID: 15217386.
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    32. Bhat NR, Shen Q, Fan F, Bhat NR, Shen Q, Fan F. TAK1-mediated induction of nitric oxide synthase gene expression in glial cells. J Neurochem. 2003 Oct; 87(1):238-47. PMID: 12969270.
      Citations: 11     Fields:    Translation:AnimalsCells
    33. Bhat NR, Sharma KK, Bhat NR, Sharma KK. Microglial activation by the small heat shock protein, alpha-crystallin. Neuroreport. 1999 Sep 09; 10(13):2869-73. PMID: 10511455.
      Citations: 7     Fields:    Translation:AnimalsCells
    34. Bhat NR, Zhang P, Bhat AN, Bhat NR, Zhang P, Bhat AN. Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: role of p38 mitogen-activated protein kinase activation. J Neurochem. 1999 Feb; 72(2):472-8. PMID: 9930718.
      Citations: 16     Fields:    Translation:AnimalsCells
    35. Bhat NR, Zhang P, Bhat NR, Zhang P. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem. 1999 Jan; 72(1):112-9. PMID: 9886061.
      Citations: 52     Fields:    Translation:AnimalsCells
    36. Andrews T, Zhang P, Bhat NR, Andrews T, Zhang P, Bhat NR. TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors. J Neurosci Res. 1998 Dec 01; 54(5):574-83. PMID: 9843148.
      Citations: 56     Fields:    Translation:AnimalsCells
    37. Bhat NR, Zhang P, Lee JC, Hogan EL, Bhat NR, Zhang P, Lee JC, Hogan EL. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci. 1998 Mar 01; 18(5):1633-41. PMID: 9464988; PMCID: PMC6792636.
      Citations: 184     Fields:    Translation:AnimalsCells
    38. Zhang P, Hogan EL, Bhat NR, Zhang P, Hogan EL, Bhat NR. Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression. Neurochem Res. 1998 Feb; 23(2):219-25. PMID: 9475517.
      Citations: 5     Fields:    Translation:AnimalsCells
    39. Sinha D, Bonner TI, Bhat NR, Matsuda LA, Sinha D, Bonner TI, Bhat NR, Matsuda LA. Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies. J Neuroimmunol. 1998 Feb; 82(1):13-21. PMID: 9526841.
      Citations: 13     Fields:    Translation:AnimalsCells
    40. Dasgupta S, Everhart MB, Bhat NR, Hogan EL, Dasgupta S, Everhart MB, Bhat NR, Hogan EL. Neutral monoglycosylceramides in rat brain: occurrence, molecular expression and developmental variation. Dev Neurosci. 1997; 19(2):152-61. PMID: 9097030.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Zhang P, Miller BS, Rosenzweig SA, Bhat NR, Zhang P, Miller BS, Rosenzweig SA, Bhat NR. Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures. J Neurosci Res. 1996 Oct 01; 46(1):114-21. PMID: 8892112.
      Citations: 24     Fields:    Translation:AnimalsCells
    42. Bhat NR, Zhang P, Bhat NR, Zhang P. Activation of mitogen-activated protein kinases in oligodendrocytes. J Neurochem. 1996 May; 66(5):1986-94. PMID: 8780027.
      Citations: 25     Fields:    Translation:AnimalsCells
    43. Bhat NR, Zhang P, Hogan EL, Bhat NR, Zhang P, Hogan EL. Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures. J Cell Physiol. 1995 Nov; 165(2):417-24. PMID: 7593220.
      Citations: 2     Fields:    Translation:AnimalsCells
    44. Namboodiri MS, Zhang P, Bhat NR, Namboodiri MS, Zhang P, Bhat NR. Hyaluronectin binds to laminin and blocks laminin-dependent process formation by astrocytes. Neuroreport. 1995 Oct 23; 6(15):2037-40. PMID: 8580435.
      Citations:    Fields:    Translation:HumansAnimalsCells
    45. Bhat NR, Zhang P, Bhat AN, Bhat NR, Zhang P, Bhat AN. The expression of myristoylated alanine-rich C-kinase substrate in oligodendrocytes is developmentally regulated. Dev Neurosci. 1995; 17(4):256-63. PMID: 8575345.
      Citations: 6     Fields:    Translation:AnimalsCells
    46. Bhat NR, Bhat NR. Signal transduction mechanisms in glial cells. Dev Neurosci. 1995; 17(5-6):267-84. PMID: 8829916.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    47. Bhat NR, Zhang P, Bhat NR, Zhang P. Inhibitors of N-linked oligosaccharide processing glucosidases interfere with oligodendrocyte differentiation in culture. J Neurosci Res. 1994 Sep 01; 39(1):1-10. PMID: 7528816.
      Citations: 3     Fields:    Translation:AnimalsCells
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