Ekhson Holmuhamedov

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InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
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    1. Rizvi F, Mirza M, Olet S, Albrecht M, Edwards S, Emelyanova L, Kress D, Ross GR, Holmuhamedov E, Tajik AJ, Khandheria BK, Jahangir A. Noninvasive biomarker-based risk stratification for development of new onset atrial fibrillation after coronary artery bypass surgery. Int J Cardiol. 2020 05 15; 307:55-62. PMID: 31952855.
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    2. Okumu DO, Aponte-Collazo LJ, Dewar BJ, Cox NJ, East MP, Tech K, McDonald IM, Tikunov AP, Holmuhamedov E, Macdonald JM, Graves LM. Lyn regulates creatine uptake in an imatinib-resistant CML cell line. Biochim Biophys Acta Gen Subj. 2020 04; 1864(4):129507. PMID: 31881245.
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    3. Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM. Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues. ACS Chem Biol. 2019 05 17; 14(5):1020-1029. PMID: 31021596.
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    4. Zotova A, Pichugin A, Atemasova A, Knyazhanskaya E, Lopatukhina E, Mitkin N, Holmuhamedov E, Gottikh M, Kuprash D, Filatov A, Mazurov D. Isolation of gene-edited cells via knock-in of short glycophosphatidylinositol-anchored epitope tags. Sci Rep. 2019 02 28; 9(1):3132. PMID: 30816313.
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    5. Rizvi F, Siddiqui R, DeFranco A, Homar P, Emelyanova L, Holmuhamedov E, Ross G, Tajik AJ, Jahangir A. Simvastatin reduces TGF-ß1-induced SMAD2/3-dependent human ventricular fibroblasts differentiation: Role of protein phosphatase activation. Int J Cardiol. 2018 Nov 01; 270:228-236. PMID: 30220377.
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    6. Emelyanova L, Preston C, Gupta A, Viqar M, Negmadjanov U, Edwards S, Kraft K, Devana K, Holmuhamedov E, O'Hair D, Tajik AJ, Jahangir A. Effect of Aging on Mitochondrial Energetics in the Human Atria. J Gerontol A Biol Sci Med Sci. 2018 04 17; 73(5):608-616. PMID: 28958065.
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    7. Chulkina M, Negmadjanov U, Lebedeva E, Pichugin A, Mazurov D, Ataullakhanov R, Holmuhamedov E. Synthetic peptide TEKKRRETVEREKE derived from ezrin induces differentiation of NIH/3T3 fibroblasts. Eur J Pharmacol. 2017 Sep 15; 811:249-259. PMID: 28668507.
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    8. Ross GR, Bajwa T, Edwards S, Emelyanova L, Rizvi F, Holmuhamedov EL, Werner P, Downey FX, Tajik AJ, Jahangir A. Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart. Biol Open. 2017 Mar 15; 6(3):326-332. PMID: 28126709.
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    9. Rizvi F, DeFranco A, Siddiqui R, Negmadjanov U, Emelyanova L, Holmuhamedov A, Ross G, Shi Y, Holmuhamedov E, Kress D, Tajik AJ, Jahangir A. Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin. . 2016 08 01; 311(2):C330-9. PMID: 27335167.
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    10. Emelyanova L, Ashary Z, Cosic M, Negmadjanov U, Ross G, Rizvi F, Olet S, Kress D, Sra J, Tajik AJ, Holmuhamedov EL, Shi Y, Jahangir A. Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation. . 2016 07 01; 311(1):H54-63. PMID: 27199126.
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    11. Nemutlu E, Gupta A, Zhang S, Viqar M, Holmuhamedov E, Terzic A, Jahangir A, Dzeja P. Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium. PLoS One. 2015; 10(9):e0136556. PMID: 26378442.
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    12. Negmadjanov U, Godic Z, Rizvi F, Emelyanova L, Ross G, Richards J, Holmuhamedov EL, Jahangir A. TGF-ß1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration. PLoS One. 2015; 10(4):e0123046. PMID: 25849590.
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    13. Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ. Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol. 2013 Nov 15; 273(1):172-9. PMID: 24012766.
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    14. Holmuhamedov EL, Oberlin A, Short K, Terzic A, Jahangir A. Cardiac subsarcolemmal and interfibrillar mitochondria display distinct responsiveness to protection by diazoxide. PLoS One. 2012; 7(9):e44667. PMID: 22973464.
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    15. Holmuhamedov EL, Czerny C, Beeson CC, Lemasters JJ. Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem. 2012 Mar 02; 287(10):7692-700. PMID: 22228763.
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    16. Johnson CB, Tikunov AP, Lee H, Wolak JE, Pediaditakis P, Romney DA, Holmuhamedov E, Gamcsik MP, Macdonald JM. ¹³C magnetic resonance spectroscopy detection of changes in serine isotopomers reflects changes in mitochondrial redox status. Magn Reson Med. 2012 Sep; 68(3):671-9. PMID: 22190282.
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    17. Lemasters JJ, Holmuhamedov EL, Czerny C, Zhong Z, Maldonado EN. Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect. Biochim Biophys Acta. 2012 Jun; 1818(6):1536-44. PMID: 22172804.
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    18. Tikunov A, Johnson CB, Pediaditakis P, Markevich N, Macdonald JM, Lemasters JJ, Holmuhamedov E. Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Arch Biochem Biophys. 2010 Mar 15; 495(2):174-81. PMID: 20097153.
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    19. Johnson TA, Stasko NA, Matthews JL, Cascio WE, Holmuhamedov EL, Johnson CB, Schoenfisch MH. Reduced ischemia/reperfusion injury via glutathione-initiated nitric oxide-releasing dendrimers. Nitric Oxide. 2010 Jan 01; 22(1):30-6. PMID: 19914388.
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    20. Holmuhamedov E, Lemasters JJ. Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys. 2009 Jan 15; 481(2):226-33. PMID: 19014900.
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    21. Preston CC, Oberlin AS, Holmuhamedov EL, Gupta A, Sagar S, Syed RH, Siddiqui SA, Raghavakaimal S, Terzic A, Jahangir A. Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart. Mech Ageing Dev. 2008 Jun; 129(6):304-12. PMID: 18400259.
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    22. Hetrick EM, Shin JH, Stasko NA, Johnson CB, Wespe DA, Holmuhamedov E, Schoenfisch MH. Bactericidal efficacy of nitric oxide-releasing silica nanoparticles. ACS Nano. 2008 Feb; 2(2):235-46. PMID: 19206623.
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    23. Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Lemasters JJ. Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology. 2008 Jan; 47(1):236-46. PMID: 18023036.
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    24. Stasko NA, Johnson CB, Schoenfisch MH, Johnson TA, Holmuhamedov EL. Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells. Biomacromolecules. 2007 Dec; 8(12):3853-9. PMID: 18004811.
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    25. Le SB, Hailer MK, Buhrow S, Wang Q, Flatten K, Pediaditakis P, Bible KC, Lewis LD, Sausville EA, Pang YP, Ames MM, Lemasters JJ, Holmuhamedov EL, Kaufmann SH. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity. J Biol Chem. 2007 Mar 23; 282(12):8860-72. PMID: 17213201.
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    26. Pokhilko AV, Ataullakhanov FI, Holmuhamedov EL. Mathematical model of mitochondrial ionic homeostasis: three modes of Ca2+ transport. J Theor Biol. 2006 Nov 07; 243(1):152-69. PMID: 16859713.
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    27. Le SB, Holmuhamedov EL, Narayanan VL, Sausville EA, Kaufmann SH. Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes. Cell Death Differ. 2006 Jan; 13(1):151-9. PMID: 16052237.
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    28. Lemasters JJ, Holmuhamedov E. Voltage-dependent anion channel (VDAC) as mitochondrial governator--thinking outside the box. Biochim Biophys Acta. 2006 Feb; 1762(2):181-90. PMID: 16307870.
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    29. He T, Peterson TE, Holmuhamedov EL, Terzic A, Caplice NM, Oberley LW, Katusic ZS. Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):2021-7. PMID: 15319267.
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    30. Holmuhamedov EL, Jahangir A, Oberlin A, Komarov A, Colombini M, Terzic A. Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett. 2004 Jun 18; 568(1-3):167-70. PMID: 15196941.
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    31. Holmuhamedov E, Jahangir A, Bienengraeber M, Lewis LD, Terzic A. Deletion of mtDNA disrupts mitochondrial function and structure, but not biogenesis. Mitochondrion. 2003 Aug; 3(1):13-9. PMID: 16120340.
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    32. Holmuhamedov E, Lewis L, Bienengraeber M, Holmuhamedova M, Jahangir A, Terzic A. Suppression of human tumor cell proliferation through mitochondrial targeting. FASEB J. 2002 Jul; 16(9):1010-6. PMID: 12087062.
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    33. Dzeja PP, Holmuhamedov EL, Ozcan C, Pucar D, Jahangir A, Terzic A. Mitochondria: gateway for cytoprotection. Circ Res. 2001 Oct 26; 89(9):744-6. PMID: 11679401.
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    34. Jahangir A, Ozcan C, Holmuhamedov EL, Terzic A. Increased calcium vulnerability of senescent cardiac mitochondria: protective role for a mitochondrial potassium channel opener. Mech Ageing Dev. 2001 Jul 31; 122(10):1073-86. PMID: 11389925.
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    35. Holmuhamedov EL, Ozcan C, Jahangir A, Terzic A. Restoration of Ca2+-inhibited oxidative phosphorylation in cardiac mitochondria by mitochondrial Ca2+ unloading. Mol Cell Biochem. 2001 Apr; 220(1-2):135-40. PMID: 11451373.
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    36. Ozcan C, Holmuhamedov EL, Jahangir A, Terzic A. Diazoxide protects mitochondria from anoxic injury: implications for myopreservation. J Thorac Cardiovasc Surg. 2001 Feb; 121(2):298-306. PMID: 11174735.
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    37. Terzic A, Dzeja PP, Holmuhamedov EL. Mitochondrial K(ATP) channels: probing molecular identity and pharmacology. J Mol Cell Cardiol. 2000 Nov; 32(11):1911-5. PMID: 11040097.
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    38. Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J Physiol. 1999 Sep 01; 519 Pt 2:347-60. PMID: 10457054.
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    39. Ulrich RG, Bacon JA, Cramer CT, Petrella DK, Sun EL, Meglasson MD, Holmuhamedov E. Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite. Toxicology. 1998 Nov 02; 131(1):33-47. PMID: 9881933.
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    40. Holmuhamedov EL, Jovanovic S, Dzeja PP, Jovanovic A, Terzic A. Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function. Am J Physiol. 1998 11; 275(5):H1567-76. PMID: 9815062.
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    41. Selivanov VA, Ichas F, Holmuhamedov EL, Jouaville LS, Evtodienko YV, Mazat JP. A model of mitochondrial Ca(2+)-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria. Biophys Chem. 1998 May 05; 72(1-2):111-21. PMID: 9652089.
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    42. Holmuhamedov EL, Kholmoukhamedova GL, Baimuradov TB. Non-cholinergic toxicity of organophosphates in mammals: interaction of ethaphos with mitochondrial functions. J Appl Toxicol. 1996 Nov-Dec; 16(6):475-81. PMID: 8956092.
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    43. Jouaville LS, Ichas F, Holmuhamedov EL, Camacho P, Lechleiter JD. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature. 1995 Oct 05; 377(6548):438-41. PMID: 7566122.
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    44. Holmuhamedov EL, Teplova VV, Chukhlova EA, Evtodienko YV, Ulrich RG. Strontium excitability of the inner mitochondrial membrane: regenerative strontium-induced strontium release. Biochem Mol Biol Int. 1995 May; 36(1):39-49. PMID: 7663421.
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    45. Ichas F, Jouaville LS, Sidash SS, Mazat JP, Holmuhamedov EL. Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling. FEBS Lett. 1994 Jul 11; 348(2):211-5. PMID: 8034044.
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    46. Holmuhamedov EL. Spatial structures in mitochondrial suspension induced by cation efflux. FEBS Lett. 1986 Jan 20; 195(1-2):339-43. PMID: 3943618.
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    47. Radeva-Domuschieva D, Maglova LM, Balevska PS, Holmuhamedov EL, Evtodienko YV. The influence of starvation on some characteristics of the Ca2+ transport system and lipid content in rat liver mitochondria. Acta Physiol Pharmacol Bulg. 1986; 12(2):49-54. PMID: 3766164.
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    48. Maglova LM, Holmuhamedov EL, Zinchenko VP, Evtodienko YV. Induction of 2H+/Me2+ exchange in rat-liver mitochondria. Eur J Biochem. 1982 Nov; 128(1):159-61. PMID: 6293824.
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    49. Wiswedel I, Barnstorf U, Augustin W, Holmuhamedov E, Medvedev B, Evtodienko Y. Involvement of periodic deacylation-acylation cycles of mitochondrial phospholipids during Sr2+-induced oscillatory ion transport in rat liver mitochondria. Biochim Biophys Acta. 1982 Jun 14; 688(2):597-604. PMID: 7104341.
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    50. Evtodienko YV, Zinchenko VP, Holmuhamedov EL, Gylkhandanyan AV, Zhabotinsky AM. The stoichiometry of ion fluxes during Sr2+-induced oscillations in mitochondria. Biochim Biophys Acta. 1980 Feb 08; 589(2):157-61. PMID: 7356981.
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