Eduardo Maldonado

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC139
DD506
Drug Discovery Building - 70 President St.
Phone843-876-2362
Fax843-876-2353
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    Collapse Biography 
    Collapse education and training
    Universidad Nacional del Centro, ArgentinaDVMVeterinary Medicine
    Universidad Nacional del Sur, ArgentinaPhDBiology/Biochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim DS, Pytel D, Kang I, Nadig SN, Beeson GC, Ball L, Mehrotra M, Wang H, Berto S, Palanisamy V, Li H, Chatterjee S, Rodriguez PC, Maldonado EN, Diehl JA, Gangaraju VK, Mehrotra S, Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim DS, Pytel D, Kang I, Nadig SN, Beeson GC, Ball L, Mehrotra M, Wang H, Berto S, Palanisamy V, Li H, Chatterjee S, Rodriguez PC, Maldonado EN, Diehl JA, Gangaraju VK, Mehrotra S. Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function. Cancer Res. 2022 05 16; 82(10):1969-1990. PMID: 35404405; PMCID: PMC9117468.
      Citations: 4     Fields:    Translation:HumansCells
    2. Heslop KA, Burger P, Kappler C, Solanki AK, Gooz M, Peterson YK, Mills C, Benton T, Duncan SA, Woster PM, Maldonado EN, Heslop KA, Burger P, Kappler C, Solanki AK, Gooz M, Peterson YK, Mills C, Benton T, Duncan SA, Woster PM, Maldonado EN. Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells. Biomed Pharmacother. 2022 Jun; 150:112928. PMID: 35447542; PMCID: PMC9400819.
      Citations: 1     Fields:    Translation:HumansCells
    3. Heslop KA, Rovini A, Gooz M, Maldonado EN, Heslop KA, Rovini A, Gooz M, Maldonado EN. Fast Determination of Mitochondrial Metabolism and Respiratory Complex Activity in Permeabilized and Intact Cells. Methods Mol Biol. 2022; 2497:1-10. PMID: 35771432.
      Citations:    Fields:    Translation:Cells
    4. Heslop KA, Milesi V, Maldonado EN, Heslop KA, Milesi V, Maldonado EN. VDAC Modulation of Cancer Metabolism: Advances and Therapeutic Challenges. Front Physiol. 2021; 12:742839. PMID: 34658929; PMCID: PMC8511398.
      Citations:    
    5. Rovini A, Heslop K, Hunt EG, Morris ME, Fang D, Gooz M, Gerencser AA, Maldonado EN, Rovini A, Heslop K, Hunt EG, Morris ME, Fang D, Gooz M, Gerencser AA, Maldonado EN. Quantitative analysis of mitochondrial membrane potential heterogeneity in unsynchronized and synchronized cancer cells. FASEB J. 2021 01; 35(1):e21148. PMID: 33196122; PMCID: PMC7871195.
      Citations:    
    6. Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD, Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. J Pharmacol Exp Ther. 2020 08; 374(2):308-318. PMID: 32546528; PMCID: PMC7372917.
      Citations:    
    7. Domondon M, Polina I, Nikiforova AB, Sultanova RF, Kruger C, Vasileva VY, Fomin MV, Beeson GC, Nieminen AL, Smythe N, Maldonado EN, Stadler K, Ilatovskaya DV, Domondon M, Polina I, Nikiforova AB, Sultanova RF, Kruger C, Vasileva VY, Fomin MV, Beeson GC, Nieminen AL, Smythe N, Maldonado EN, Stadler K, Ilatovskaya DV. Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension. Front Physiol. 2019; 10:1588. PMID: 32116733; PMCID: PMC7010849.
      Citations:    
    8. Christie CF, Fang D, Hunt EG, Morris ME, Rovini A, Heslop KA, Beeson GC, Beeson CC, Maldonado EN, Christie CF, Fang D, Hunt EG, Morris ME, Rovini A, Heslop KA, Beeson GC, Beeson CC, Maldonado EN. Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content. FASEB J. 2019 07; 33(7):8186-8201. PMID: 30951369; PMCID: PMC6593894.
      Citations:    
    9. Orr RK, Hoehn JL, Col NF, Fang D, Maldonado EN. VDAC Regulation: A Mitochondrial Target to Stop Cell Proliferation. Adv Cancer Res. 2018; 138:41-69. PMID: 29551129; PMCID: PMC6234976.
      Citations:    
    10. DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN, DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN. Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol. 2018 02; 148:155-162. PMID: 29289511; PMCID: PMC5909406.
      Citations:    
    11. Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ, Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator. J Biol Chem. 2017 10 13; 292(41):16969. PMID: 29030537; PMCID: PMC5641883.
      Citations:    
    12. DeHart DN, Lemasters JJ, Maldonado EN, DeHart DN, Lemasters JJ, Maldonado EN. Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov. 2018 01; 23(1):23-33. PMID: 29024608; PMCID: PMC5927820.
      Citations:    
    13. Maldonado EN, Maldonado EN. VDAC-Tubulin, an Anti-Warburg Pro-Oxidant Switch. Front Oncol. 2017; 7:4. PMID: 28168164; PMCID: PMC5256068.
      Citations:    
    14. Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ, Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem. 2016 09 09; 291(37):19642-50. PMID: 27458020; PMCID: PMC5016697.
      Citations:    
    15. Maldonado EN, Delgado I, Furland NE, Buqué X, Iglesias A, Aveldaño MI, Zubiaga A, Fresnedo O, Ochoa B, Maldonado EN, Delgado I, Furland NE, Buqu? X, Iglesias A, Avelda?o MI, Zubiaga A, Fresnedo O, Ochoa B. The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice. PLoS One. 2014; 9(11):e112620. PMID: 25396754; PMCID: PMC4232400.
      Citations:    
    16. Maldonado EN, Lemasters JJ, Maldonado EN, Lemasters JJ. ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect. Mitochondrion. 2014 Nov; 19 Pt A:78-84. PMID: 25229666; PMCID: PMC4254332.
      Citations:    
    17. Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD, Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD. ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F551-9. PMID: 24899059; PMCID: PMC4154111.
      Citations:    
    18. Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ, Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ. Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. 2013 Apr 26; 288(17):11920-9. PMID: 23471966; PMCID: PMC3636879.
      Citations:    
    19. Orr RK, Hoehn JL, Col NF, Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB Surg. 2012; 2012:641982. PMID: 22791932; PMCID: PMC3390051.
      Citations:    
    20. Maldonado EN, Lemasters JJ, Maldonado EN, Lemasters JJ. Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther. 2012 Sep; 342(3):637-41. PMID: 22700429; PMCID: PMC3422523.
      Citations:    
    21. Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ, Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB Surg. 2012; 2012:259512. PMID: 22719175; PMCID: PMC3375163.
      Citations:    
    22. Lemasters JJ, Holmuhamedov EL, Czerny C, Zhong Z, Maldonado EN, Lemasters JJ, Holmuhamedov EL, Czerny C, Zhong Z, Maldonado EN. Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect. Biochim Biophys Acta. 2012 Jun; 1818(6):1536-44. PMID: 22172804; PMCID: PMC3422743.
      Citations:    
    23. Sheldon KL, Maldonado EN, Lemasters JJ, Rostovtseva TK, Bezrukov SM, Sheldon KL, Maldonado EN, Lemasters JJ, Rostovtseva TK, Bezrukov SM. Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One. 2011; 6(10):e25539. PMID: 22022409; PMCID: PMC3192757.
      Citations:    
    24. Maldonado EN, Patnaik J, Mullins MR, Lemasters JJ, Maldonado EN, Patnaik J, Mullins MR, Lemasters JJ. Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res. 2010 Dec 15; 70(24):10192-201. PMID: 21159641; PMCID: PMC3010233.
      Citations:    
    25. Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ, Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy. 2009 Nov; 5(8):1099-106. PMID: 19783904; PMCID: PMC4170191.
      Citations:    
    26. Maldonado EN, Alderson NL, Monje PV, Wood PM, Hama H, Maldonado EN, Alderson NL, Monje PV, Wood PM, Hama H. FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin. J Lipid Res. 2008 Jan; 49(1):153-61. PMID: 17901466; PMCID: PMC2662131.
      Citations:    
    27. Zanetti SR, Maldonado EN, Aveldaño MI, Zanetti SR, Maldonado EN, Avelda?o MI. Doxorubicin affects testicular lipids with long-chain (C18-C22) and very long-chain (C24-C32) polyunsaturated fatty acids. Cancer Res. 2007 Jul 15; 67(14):6973-80. PMID: 17638909.
      Citations:    
    28. Furland NE, Maldonado EN, Aresti PA, Aveldaño MI, Furland NE, Maldonado EN, Aresti PA, Avelda?o MI. Changes in lipids containing long- and very long-chain polyunsaturated fatty acids in cryptorchid rat testes. Biol Reprod. 2007 Jul; 77(1):181-8. PMID: 17429018.
      Citations:    
    29. Furland NE, Oresti GM, Antollini SS, Venturino A, Maldonado EN, Aveldaño MI, Furland NE, Oresti GM, Antollini SS, Venturino A, Maldonado EN, Avelda?o MI. Very long-chain polyunsaturated fatty acids are the major acyl groups of sphingomyelins and ceramides in the head of mammalian spermatozoa. J Biol Chem. 2007 Jun 22; 282(25):18151-18161. PMID: 17392275.
      Citations:    
    30. Furland NE, Zanetti SR, Oresti GM, Maldonado EN, Aveldaño MI, Furland NE, Zanetti SR, Oresti GM, Maldonado EN, Avelda?o MI. Ceramides and sphingomyelins with high proportions of very long-chain polyunsaturated fatty acids in mammalian germ cells. J Biol Chem. 2007 Jun 22; 282(25):18141-18150. PMID: 17392276.
      Citations:    
    31. Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H, Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006 Dec; 47(12):2772-80. PMID: 16998236.
      Citations:    
    32. Pérez S, Maldonado EN, Aspichueta P, Ochoa B, Chico Y, P?rez S, Maldonado EN, Aspichueta P, Ochoa B, Chico Y. Differential modulation of prostaglandin receptor mRNA abundance by prostaglandins in primary cultured rat hepatocytes. Mol Cell Biochem. 2004 Nov; 266(1-2):183-9. PMID: 15646041.
      Citations:    
    33. Maldonado EN, Chico Y, Botham KM, Aveldaño MI, Ochoa B, Maldonado EN, Chico Y, Botham KM, Avelda?o MI, Ochoa B. Influence of the fatty acid composition of lipids in chylomicron remnants derived from fish or corn oil on the lipid profile of cultured rat hepatocytes. J Physiol Biochem. 2003 Jun; 59(2):85-100. PMID: 14649874.
      Citations:    Fields:    Translation:AnimalsCells
    34. Furland NE, Maldonado EN, Aveldaño MI, Furland NE, Maldonado EN, Avelda?o MI. Very long chain PUFA in murine testicular triglycerides and cholesterol esters. Lipids. 2003 Jan; 38(1):73-80. PMID: 12669822.
      Citations: 11     Fields:    Translation:Animals
    35. Maldonado EN, Casanave EB, Aveldaño MI, Maldonado EN, Casanave EB, Avelda?o MI. Major plasma lipids and fatty acids in four HDL mammals. Comp Biochem Physiol A Mol Integr Physiol. 2002 Jun; 132(2):297-303. PMID: 12020646.
      Citations: 4     Fields:    Translation:Animals
    36. Maldonado EN, Furland NE, Pennacchiotti GL, Aveldano MI, Maldonado EN, Furland NE, Pennacchiotti GL, Aveldano MI. Reversibility of the changes induced by n-3 fatty acids in mouse plasma, liver and blood cell lipids. J Nutr Biochem. 2002 Jan; 13(1):36-46. PMID: 11834218.
      Citations:    
    37. Botham KM, Maldonado EN, Chico Y, Zheng X, Avella M, Ochoa B, Botham KM, Maldonado EN, Chico Y, Zheng X, Avella M, Ochoa B. The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids. Biochim Biophys Acta. 2001 Dec 30; 1534(2-3):96-109. PMID: 11786296.
      Citations: 3     Fields:    Translation:AnimalsCells
    38. Maldonado EN, Romero JR, Ochoa B, Aveldaño MI, Maldonado EN, Romero JR, Ochoa B, Avelda?o MI. Lipid and fatty acid composition of canine lipoproteins. Comp Biochem Physiol B Biochem Mol Biol. 2001 Apr; 128(4):719-29. PMID: 11290454.
      Citations: 14     Fields:    Translation:HumansAnimals
    39. Pennacchiotti GL, Maldonado EN, Aveldaño MI, Pennacchiotti GL, Maldonado EN, Avelda?o MI. Major clofibrate effects on liver and plasma lipids are independent of changes in polyunsaturated fatty acid composition induced by dietary fat. Lipids. 2001 Feb; 36(2):121-7. PMID: 11269691.
      Citations: 1     Fields:    Translation:Animals
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