Peggi Melissa Angel

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
CRI315
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-8410
Fax843-792-2475
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. DelaCourt AT, Liang H, Drake RR, Angel PM, Mehta AS. Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry. J Proteome Res. 2022 08 05; 21(8):1930-1938. PMID: 35766466.
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    2. Rujchanarong D, Scott D, Park Y, Brown S, Mehta AS, Drake R, Sandusky GE, Nakshatri H, Angel PM. Metabolic Links to Socioeconomic Stresses Uniquely Affecting Ancestry in Normal Breast Tissue at Risk for Breast Cancer. Front Oncol. 2022; 12:876651. PMID: 35832545.
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    3. Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC. Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human. Mol Cell Proteomics. 2022 05; 21(5):100225. PMID: 35331917.
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    4. Angel PM, Zambrzycki SC. Predictive value of collagen in cancer. Adv Cancer Res. 2022; 154:15-45. PMID: 35459468.
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    5. Angel PM. Review of the ASMS 2021 Fall Workshop on MALDI Imaging Mass Spectrometry. J Am Soc Mass Spectrom. 2022 03 02; 33(3):407-408. PMID: 35147427.
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    6. Scott DA, Wang M, Grauzam S, Pippin S, Black A, Angel PM, Drake RR, Castellino S, Kono Y, Rockey DC, Mehta AS. GlycoFibroTyper: A Novel Method for the Glycan Analysis of IgG and the Development of a Biomarker Signature of Liver Fibrosis. Front Immunol. 2022; 13:797460. PMID: 35197973.
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    7. Chandler CE, Anderton CR, Scott AJ, Charkoftaki G, Angel PM, Drake RR. Review of the Third Conference of the Imaging Mass Spectrometry Society (IMSS 3): Accounts of a Hybrid Virtual and In-Person Meeting and the State and Future of the Field. J Am Soc Mass Spectrom. 2022 Feb 02; 33(2):238-241. PMID: 35005981.
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    8. Klaver EJ, Dukes-Rimsky L, Kumar B, Xia ZJ, Dang T, Lehrman MA, Angel P, Drake RR, Freeze HH, Steet R, Flanagan-Steet H. Protease-dependent defects in N-cadherin processing drive PMM2-CDG pathogenesis. JCI Insight. 2021 12 22; 6(24). PMID: 34784297.
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    9. Pace CL, Angel PM, Drake RR, Muddiman DC. Mass Spectrometry Imaging of N-Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization. J Proteome Res. 2022 01 07; 21(1):243-249. PMID: 34860526.
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    10. McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C. Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients. Transpl Immunol. 2022 04; 71:101491. PMID: 34767945.
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    11. Clift CL, McLaughlin S, Muñoz M, Suuronen EJ, Rotstein BH, Mehta AS, Drake RR, Alarcon EI, Angel PM. Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry. J Am Soc Mass Spectrom. 2021 Dec 01; 32(12):2746-2754. PMID: 34713699.
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    12. Rujchanarong D, Lefler J, Saunders JE, Pippin S, Spruill L, Bethard JR, Ball LE, Mehta AS, Drake RR, Ostrowski MC, Angel PM. Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry. Cancers (Basel). 2021 Sep 01; 13(17). PMID: 34503228.
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    13. McDowell CT, Lu X, Mehta AS, Angel PM, Drake RR. Applications and continued evolution of glycan imaging mass spectrometry. Mass Spectrom Rev. 2021 Aug 15. PMID: 34392557.
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    14. DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS. N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes. Mol Cancer Res. 2021 11; 19(11):1868-1877. PMID: 34380744.
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    15. McQuiston A, Emtiazjoo A, Angel P, Machuca T, Christie J, Atkinson C. Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant. Front Immunol. 2021; 12:711102. PMID: 34456920.
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    16. Angel PM, Rujchanarong D, Pippin S, Spruill L, Drake R. Mass Spectrometry Imaging of Fibroblasts: Promise and Challenge. Expert Rev Proteomics. 2021 06; 18(6):423-436. PMID: 34129411.
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    17. Halbert CH, Jefferson M, Allen CG, Babatunde OA, Drake R, Angel P, Savage SJ, Frey L, Lilly M, Obi T, Obeid J. Racial Differences in Patient Portal Activation and Research Enrollment Among Patients With Prostate Cancer. JCO Clin Cancer Inform. 2021 06; 5:768-774. PMID: 34328797.
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    18. Clift CL, Su YR, Bichell D, Jensen Smith HC, Bethard JR, Norris-Caneda K, Comte-Walters S, Ball LE, Hollingsworth MA, Mehta AS, Drake RR, Angel PM. Collagen fiber regulation in human pediatric aortic valve development and disease. Sci Rep. 2021 05 07; 11(1):9751. PMID: 33963260.
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    19. Blaschke CRK, McDowell CT, Black AP, Mehta AS, Angel PM, Drake RR. Glycan Imaging Mass Spectrometry: Progress in Developing Clinical Diagnostic Assays for Tissues, Biofluids, and Cells. Clin Lab Med. 2021 06; 41(2):247-266. PMID: 34020762.
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    20. Angel PM. On the Cutting Edge of Translational Research. Clin Chem. 2021 03 31; 67(4):583-584. PMID: 33230521.
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    21. Angel PM, Drake RR, Park Y, Clift CL, West C, Berkhiser S, Hardiman G, Mehta AS, Bichell DP, Su YR. Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis. J Mol Cell Cardiol. 2021 05; 154:6-20. PMID: 33516683.
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    22. Sundararaj K, Rodgers J, Angel P, Wolf B, Nowling TK. The role of neuraminidase in TLR4-MAPK signalling and the release of cytokines by lupus serum-stimulated mesangial cells. Immunology. 2021 04; 162(4):418-433. PMID: 33314123.
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    23. Clift CL, Mehta A, Drake RR, Angel PM. Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research. Methods Mol Biol. 2021; 2350:313-329. PMID: 34331294.
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    24. Angel PM, Mehta AS, Drake RR. Array-Based N-Glycan Profiling of Cells in Culture. Methods Mol Biol. 2021; 2271:331-342. PMID: 33908018.
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    25. West CA, Lu X, Grimsley G, Norris-Caneda K, Mehta AS, Angel PM, Drake RR. Optimization of Multiple Glycosidase and Chemical Stabilization Strategies for N-Glycan Isomer Detection by Mass Spectrometry Imaging in Formalin-Fixed, Paraffin-Embedded Tissues. Methods Mol Biol. 2021; 2271:303-316. PMID: 33908016.
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    26. McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel PM, Mehta AS, Lewin DN, Haab BB, Drake RR. Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen-Defined Pancreatic Cancer Tissues. Mol Cell Proteomics. 2021; 20:100012. PMID: 33581409.
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    27. Clift CL, Drake RR, Mehta A, Angel PM. Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections. Anal Bioanal Chem. 2021 Apr; 413(10):2709-2719. PMID: 33206215.
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    28. Blaschke CRK, Black AP, Mehta AS, Angel PM, Drake RR. Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow. J Am Soc Mass Spectrom. 2020 Dec 02; 31(12):2511-2520. PMID: 32809822.
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    29. Angel PM, Spruill L, Jefferson M, Bethard JR, Ball LE, Hughes-Halbert C, Drake RR. Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry. Prostate. 2020 09; 80(13):1071-1086. PMID: 32687633.
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    30. Holmes DT, Romney MG, Angel P, DeMarco ML. Proteomic applications in pathology and laboratory medicine: Present state and future prospects. Clin Biochem. 2020 Aug; 82:12-20. PMID: 32442429.
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    31. Angel PM, Bruner E, Bethard J, Clift CL, Ball L, Drake RR, Feghali-Bostwick C. Extracellular matrix alterations in low-grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry. J Mass Spectrom. 2020 Apr; 55(4):e4450. PMID: 31654589.
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    32. Drake RR, McDowell C, West C, David F, Powers TW, Nowling T, Bruner E, Mehta AS, Angel PM, Marlow LA, Tun HW, Copland JA. Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry. J Mass Spectrom. 2020 Apr; 55(4):e4490. PMID: 31860772.
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    33. Black AP, Angel PM, Drake RR, Mehta AS. Antibody Panel Based N-Glycan Imaging for N-Glycoprotein Biomarker Discovery. Curr Protoc Protein Sci. 2019 12; 98(1):e99. PMID: 31721442.
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    34. Pati S, Angel P, Drake RR, Wagner JJ, Cummings BS. Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug-seeking. Brain Behav. 2019 12; 9(12):e01451. PMID: 31701674.
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    35. Drake RR, Angel PM, Wu J, Pachynski RK, Ippolito JE. How else can we approach prostate cancer biomarker discovery? Expert Rev Mol Diagn. 2020 02; 20(2):123-125. PMID: 31498690.
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    36. Black AP, Liang H, West CA, Wang M, Herrera HP, Haab BB, Angel PM, Drake RR, Mehta AS. A Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging. Anal Chem. 2019 07 02; 91(13):8429-8435. PMID: 31177770.
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    37. Herrera H, Dilday T, Uber A, Scott D, Zambrano JN, Wang M, Angel PM, Mehta AS, Drake RR, Hill EG, Yeh ES. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019 May 23; 20(10). PMID: 31126011.
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    38. Yang L, Kraemer M, Fang XF, Angel PM, Drake RR, Morris AJ, Smyth SS. LPA receptor 4 deficiency attenuates experimental atherosclerosis. J Lipid Res. 2019 05; 60(5):972-980. PMID: 30796085.
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    39. Angel PM, Schwamborn K, Comte-Walters S, Clift CL, Ball LE, Mehta AS, Drake RR. Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI-Imaging Mass Spectrometry. Proteomics Clin Appl. 2019 01; 13(1):e1700152. PMID: 30251340.
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    40. West CA, Wang M, Herrera H, Liang H, Black A, Angel PM, Drake RR, Mehta AS. N-Linked Glycan Branching and Fucosylation Are Increased Directly in Hcc Tissue As Determined through in Situ Glycan Imaging. J Proteome Res. 2018 10 05; 17(10):3454-3462. PMID: 30110170.
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    41. Angel PM, Norris-Caneda K, Drake RR. In Situ Imaging of Tryptic Peptides by MALDI Imaging Mass Spectrometry Using Fresh-Frozen or Formalin-Fixed, Paraffin-Embedded Tissue. Curr Protoc Protein Sci. 2018 11; 94(1):e65. PMID: 30114342.
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    42. Drake RR, Powers TW, Norris-Caneda K, Mehta AS, Angel PM. In Situ Imaging of N-Glycans by MALDI Imaging Mass Spectrometry of Fresh or Formalin-Fixed Paraffin-Embedded Tissue. Curr Protoc Protein Sci. 2018 11; 94(1):e68. PMID: 30074304.
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    43. Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C. Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep. 2018 01 26; 8(1):1627. PMID: 29374263.
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    44. Scott DA, Norris-Caneda K, Spruill L, Bruner E, Kono Y, Angel PM, Mehta AS, Drake RR. Specific N-Linked Glycosylation Patterns in Areas of Necrosis in Tumor Tissues. Int J Mass Spectrom. 2019 Mar; 437:69-76. PMID: 31031563.
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    45. Angel PM, Mehta A, Norris-Caneda K, Drake RR. MALDI Imaging Mass Spectrometry of N-glycans and Tryptic Peptides from the Same Formalin-Fixed, Paraffin-Embedded Tissue Section. Methods Mol Biol. 2018; 1788:225-241. PMID: 29058228.
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    46. Drake RR, West CA, Mehta AS, Angel PM. MALDI Mass Spectrometry Imaging of N-Linked Glycans in Tissues. Adv Exp Med Biol. 2018; 1104:59-76. PMID: 30484244.
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    47. Angel PM, Comte-Walters S, Ball LE, Talbot K, Mehta A, Brockbank KGM, Drake RR. Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry. J Proteome Res. 2018 01 05; 17(1):635-646. PMID: 29161047.
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    48. Angel PM, Baldwin HS, Gottlieb Sen D, Su YR, Mayer JE, Bichell D, Drake RR. Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve. Biochim Biophys Acta Proteins Proteom. 2017 Jul; 1865(7):927-935. PMID: 28341601.
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    49. Angel PM, Bayoumi AS, Hinton RB, Ru Su Y, Bichell D, Mayer JE, Scott Baldwin H, Caprioli RM. MALDI Imaging Mass Spectrometry as a Lipidomic Approach to Heart Valve Research. J Heart Valve Dis. 2016 03; 25(2):240-252. PMID: 27989075.
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    50. Paglia G, Stocchero M, Cacciatore S, Lai S, Angel P, Alam MT, Keller M, Ralser M, Astarita G. Unbiased Metabolomic Investigation of Alzheimer's Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism. J Proteome Res. 2016 Feb 05; 15(2):608-18. PMID: 26717242.
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    51. Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF. Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype. Exp Hematol. 2016 Jan; 44(1):50-9.e1-2. PMID: 26407636.
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    52. Paglia G, Angel P, Williams JP, Richardson K, Olivos HJ, Thompson JW, Menikarachchi L, Lai S, Walsh C, Moseley A, Plumb RS, Grant DF, Palsson BO, Langridge J, Geromanos S, Astarita G. Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification. Anal Chem. 2015 Jan 20; 87(2):1137-44. PMID: 25495617.
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    53. Wattacheril J, Seeley EH, Angel P, Chen H, Bowen BP, Lanciault C, Caprioli RM, Abumrad N, Flynn CR. Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. PLoS One. 2013; 8(2):e57165. PMID: 23451176.
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    54. Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince LS, Baldwin S, Schutte BC. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One. 2013; 8(2):e56270. PMID: 23451037.
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    55. Angel PM, Caprioli RM. Matrix-assisted laser desorption ionization imaging mass spectrometry: in situ molecular mapping. Biochemistry. 2013 Jun 04; 52(22):3818-28. PMID: 23259809.
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    56. Angel PM, Spraggins JM, Baldwin HS, Caprioli R. Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry. Anal Chem. 2012 Feb 07; 84(3):1557-64. PMID: 22243218.
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    57. Gerwe BA, Angel PM, West FD, Hasneen K, Young A, Orlando R, Stice SL. Membrane proteomic signatures of karyotypically normal and abnormal human embryonic stem cell lines and derivatives. Proteomics. 2011 Jun; 11(12):2515-27. PMID: 21598385.
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    58. Mainini V, Angel PM, Magni F, Caprioli RM. Detergent enhancement of on-tissue protein analysis by matrix-assisted laser desorption/ionization imaging mass spectrometry. Rapid Commun Mass Spectrom. 2011 Jan 15; 25(1):199-204. PMID: 21157864.
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    59. Angel PM, Nusinow D, Brown CB, Violette K, Barnett JV, Zhang B, Baldwin HS, Caprioli RM. Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves. J Proteome Res. 2011 Feb 04; 10(2):812-23. PMID: 21133377.
      Citations:    
    60. Chaurand P, Cornett DS, Angel PM, Caprioli RM. From whole-body sections down to cellular level, multiscale imaging of phospholipids by MALDI mass spectrometry. Mol Cell Proteomics. 2011 Feb; 10(2):O110.004259. PMID: 20736411.
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    61. Reyzer ML, Chaurand P, Angel PM, Caprioli RM. Direct molecular analysis of whole-body animal tissue sections by MALDI imaging mass spectrometry. Methods Mol Biol. 2010; 656:285-301. PMID: 20680598.
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    62. Orlando R, Lim JM, Atwood JA, Angel PM, Fang M, Aoki K, Alvarez-Manilla G, Moremen KW, York WS, Tiemeyer M, Pierce M, Dalton S, Wells L. IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J Proteome Res. 2009 Aug; 8(8):3816-23. PMID: 19449840.
      Citations:    
    63. Lim JM, Aoki K, Angel P, Garrison D, King D, Tiemeyer M, Bergmann C, Wells L. Mapping glycans onto specific N-linked glycosylation sites of Pyrus communis PGIP redefines the interface for EPG-PGIP interactions. J Proteome Res. 2009 Feb; 8(2):673-80. PMID: 19072240.
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    64. Angel PM, Lim JM, Wells L, Bergmann C, Orlando R. A potential pitfall in 18O-based N-linked glycosylation site mapping. Rapid Commun Mass Spectrom. 2007; 21(5):674-82. PMID: 17279607.
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    65. Angel PM, Orlando R. Quantitative carbamylation as a stable isotopic labeling method for comparative proteomics. Rapid Commun Mass Spectrom. 2007; 21(10):1623-34. PMID: 17465008.
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    66. Angel PM, Orlando R. Trypsin is the primary mechanism by which the (18)O isotopic label is lost in quantitative proteomic studies. Anal Biochem. 2006 Dec 01; 359(1):26-34. PMID: 17046705.
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    67. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 31535553.
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    68. Orr RK, Hoehn JL, Col NF. The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg. 1999 Jul; 134(7):764-7. PMID: 35459474.
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