Ann-Marie Broome

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
BSB319D
Basic Science Building - 173 Ashley Ave.
Phone843-876-2481
Fax843-792-2475
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    The academic research program of Ann-Marie Broome, Ph.D., MBA, the Director of Molecular Imaging of the Medical University of South Carolina’s Center for Biomedical Imaging and Director of Small Animal Imaging of MUSC’s Hollings Cancer Center, is devoted to the study and understanding of different diseases for the purposes of detecting them earlier and improving therapeutic efficacy–the hallmarks of the molecular imaging field. Molecular imaging, a cross-disciplinary field combining science, engineering and medicine, bridges basic and clinically translatable research. Its ultimate goal is to characterize and measure biological processes at the cellular and molecular levels both noninvasively and in real-time. Dr. Broome’s research utilizes bio-inspired nanotechnology to study cancer in its earliest stages of progression, by developing novel multi-modal contrast agents and multi-functional delivery vehicles to target and monitor therapeutic response. By exploiting unique validated, disease-associated changes in gene and protein expression, also known as the cancer signature, Dr. Broome is able to bioengineer theranostic agents to selectively and robustly image the cellular status of genetically distinct cancers, the gold standard of personalized medicine, thereby facilitating detection, diagnosis, assessment of progression and prediction of treatment outcome. This increased selectivity and sensitivity could also lead to meaningful improvements in determining a tumor’s location, focality, extent and differentiation in relation to the cancer microenvironment.

    Before coming to MUSC, as a primary investigator (PI) and co-PI on several funded NIH and university-sponsored grants, she laid the groundwork for research into the development of platform imaging technologies that can target and visualize multiple biomarkers simultaneously. Additionally, her laboratory engineered several animal models of inaccessible or surgically challenging tumors, such as the orthotopic human brain tumor model for glioblastomas. Currently, Dr. Broome is the PI of a multi-institutional NIH/NIBIB R01 grant investigating novel molecular imaging paradigms to image tumor uptake, accumulation and activation of hydrophobic photosensitizing agents. In this project, she is able to monitor the drug response using the intrinsic fluorescence properties of the drug and to quantify its impact on tumor progression. She is also PI on a Department of Defense Peer-Reviewed Cancer Research Program Idea Award examining split-reporters to achieve chemical resolution of cancer protein profiles using molecular imaging.
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    Cell and Molecular Pharmacology and Experimental Therapeutics

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khan I, MarElia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, Pécot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP, Khan I, Marelia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, Connor DM, Broome AM, P?cot T, Timmers C, Ostrowski MC, Koide S, O'Bryan JP. Targeting the KRAS a4-a5 allosteric interface inhibits pancreatic cancer tumorigenesis. Small GTPases. 2022 Jan; 13(1):114-127. PMID: 33949915; PMCID: PMC9707541.
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    2. Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD, Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. J Pharmacol Exp Ther. 2020 08; 374(2):308-318. PMID: 32546528; PMCID: PMC7372917.
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    3. Nair-Menon J, Daulagala AC, Connor DM, Rutledge L, Penix T, Bridges MC, Wellslager B, Spyropoulos DD, Timmers CD, Broome AM, Kourtidis A, Nair-Menon J, Daulagala AC, Connor DM, Rutledge L, Penix T, Bridges MC, Wellslager B, Spyropoulos DD, Timmers CD, Broome AM, Kourtidis A. Predominant Distribution of the RNAi Machinery at Apical Adherens Junctions in Colonic Epithelia Is Disrupted in Cancer. Int J Mol Sci. 2020 Apr 07; 21(7). PMID: 32272708; PMCID: PMC7177752.
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    4. Garcia D, Nasarre P, Bonilla IV, Hilliard E, Peterson YK, Spruill L, Broome AM, Hill EG, Yustein JT, Mehrotra S, Klauber-DeMore N, Garcia D, Nasarre P, Bonilla IV, Hilliard E, Peterson YK, Spruill L, Broome AM, Hill EG, Yustein JT, Mehrotra S, Klauber-DeMore N. Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo. Ann Surg Oncol. 2019 Dec; 26(13):4782-4790. PMID: 31515721; PMCID: PMC8261905.
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    5. Jiang YL, Broome AM, Jiang YL, Broome AM. Novel Pyrene Excimer and Fluorogenic Probe for the Detection of Alkylating Agents. ACS Sens. 2019 07 26; 4(7):1791-1797. PMID: 31299153.
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    6. Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD, Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1. Cancer Res. 2019 08 15; 79(16):4072-4085. PMID: 31227482; PMCID: PMC6697583.
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    7. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H, Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405; PMCID: PMC6380957.
      Citations:    
    8. Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D, Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D. Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. Drug Deliv. 2018 Nov; 25(1):973-984. PMID: 29688083; PMCID: PMC6058514.
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    9. Zhu P, Atkinson C, Dixit S, Cheng Q, Tran D, Patel K, Jiang YL, Esckilsen S, Miller K, Bazzle G, Allen P, Moore A, Broome AM, Nadig SN, Zhu P, Atkinson C, Dixit S, Cheng Q, Tran D, Patel K, Jiang YL, Esckilsen S, Miller K, Bazzle G, Allen P, Moore A, Broome AM, Nadig SN. Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo. RSC Adv. 2018 Jul 23; 8(46):25909-25919. PMID: 30220998; PMCID: PMC6124302.
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    10. Orr RK, Hoehn JL, Col NF, Connor DM, Broome AM. Gold Nanoparticles for the Delivery of Cancer Therapeutics. Adv Cancer Res. 2018; 139:163-184. PMID: 29941104.
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    11. Broome AM, Broome AM. Preface. Adv Cancer Res. 2018; 139:xiii-xiv. PMID: 29941109.
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    12. Jiang YL, Zhu Y, Moore AB, Miller K, Broome AM, Jiang YL, Zhu Y, Moore AB, Miller K, Broome AM. Biotinylated Bioluminescent Probe for Long Lasting Targeted in Vivo Imaging of Xenografted Brain Tumors in Mice. ACS Chem Neurosci. 2018 01 17; 9(1):100-106. PMID: 28532151; PMCID: PMC5947857.
      Citations:    
    13. McKinnon E, Moore A, Dixit S, Zhu Y, Broome AM, McKinnon E, Moore A, Dixit S, Zhu Y, Broome AM. Fluorescence and Bioluminescence Imaging of Orthotopic Brain Tumors in Mice. Methods Mol Biol. 2017; 1530:283-305. PMID: 28150209.
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    14. Bredlau AL, Dixit S, Chen C, Broome AM, Bredlau AL, Dixit S, Chen C, Broome AM. Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma. Curr Neuropharmacol. 2017; 15(1):104-115. PMID: 26903150; PMCID: PMC5327462.
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    15. Miller K, Dixit S, Bredlau AL, Moore A, McKinnon E, Broome AM, Miller K, Dixit S, Bredlau AL, Moore A, McKinnon E, Broome AM. Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond). 2016 Mar; 11(6):581-95. PMID: 27003178; PMCID: PMC5561905.
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    16. Bredlau AL, McCrackin MA, Motamarry A, Helke K, Chen C, Broome AM, Haemmerich D, Bredlau AL, McCrackin MA, Motamarry A, Helke K, Chen C, Broome AM, Haemmerich D. Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans. Crit Rev Biomed Eng. 2016; 44(6):443-457. PMID: 29431091; PMCID: PMC5894118.
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    17. Dixit S, Miller K, Zhu Y, McKinnon E, Novak T, Kenney ME, Broome AM, Dixit S, Miller K, Zhu Y, McKinnon E, Novak T, Kenney ME, Broome AM. Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas. Mol Pharm. 2015 Sep 08; 12(9):3250-60. PMID: 26198693; PMCID: PMC4564323.
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    18. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA, Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302; PMCID: PMC4720389.
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    19. Nadig SN, Dixit SK, Levey N, Esckilsen S, Miller K, Dennis W, Atkinson C, Broome AM, Nadig SN, Dixit SK, Levey N, Esckilsen S, Miller K, Dennis W, Atkinson C, Broome AM. Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity. RSC Adv. 2015; 5(54):43552-43562. PMID: 26167278; PMCID: PMC4494678.
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    20. Meyers JD, Cheng Y, Broome A-M, Agnes RS, Schluchter M, Margevicius S, Wang X, Kenney ME, Burda C, and Basilion JP. Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Particle & Particle Systems Characterization. 2015; 32(4):448-457.
    21. Meyers JD, Cheng Y, Broome AM, Agnes RS, Schluchter MD, Margevicius S, Wang X, Kenney ME, Burda C, Basilion JP, Meyers JD, Cheng Y, Broome AM, Agnes RS, Schluchter MD, Margevicius S, Wang X, Kenney ME, Burda C, Basilion JP. Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Part Part Syst Charact. 2015 Apr; 32(4):448-457. PMID: 25999665; PMCID: PMC4437573.
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    22. Broome AM, Ramamurthy G, Lavik K, Liggett A, Kinstlinger I, Basilion J, Broome AM, Ramamurthy G, Lavik K, Liggett A, Kinstlinger I, Basilion J. Optical imaging of targeted ?-galactosidase in brain tumors to detect EGFR levels. Bioconjug Chem. 2015 Apr 15; 26(4):660-8. PMID: 25775241; PMCID: PMC4437618.
      Citations:    
    23. Dixit S, Novak T, Miller K, Zhu Y, Kenney ME, Broome AM, Dixit S, Novak T, Miller K, Zhu Y, Kenney ME, Broome AM. Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale. 2015 Feb 07; 7(5):1782-90. PMID: 25519743; PMCID: PMC4437576.
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    24. Perera RH, Solorio L, Wu H, Gangolli M, Silverman E, Hernandez C, Peiris PM, Broome AM, Exner AA, Perera RH, Solorio L, Wu H, Gangolli M, Silverman E, Hernandez C, Peiris PM, Broome AM, Exner AA. Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation. Pharm Res. 2014 Jun; 31(6):1407-17. PMID: 23943542; PMCID: PMC3925199.
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    25. Shukla S, Wen AM, Ayat NR, Commandeur U, Gopalkrishnan R, Broome AM, Lozada KW, Keri RA, Steinmetz NF, Shukla S, Wen AM, Ayat NR, Commandeur U, Gopalkrishnan R, Broome AM, Lozada KW, Keri RA, Steinmetz NF. Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine (Lond). 2014 Feb; 9(2):221-35. PMID: 23834501; PMCID: PMC4169171.
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    26. Agnes RS, Broome AM, Wang J, Verma A, Lavik K, Basilion JP, Agnes RS, Broome AM, Wang J, Verma A, Lavik K, Basilion JP. An optical probe for noninvasive molecular imaging of orthotopic brain tumors overexpressing epidermal growth factor receptor. Mol Cancer Ther. 2012 Oct; 11(10):2202-11. PMID: 22807580; PMCID: PMC3829608.
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    27. Orr RK, Hoehn JL, Col NF, Cheng Y, Meyers JD, Agnes RS, Doane TL, Kenney ME, Broome AM, Burda C, Basilion JP. Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery? Small. 2011 Aug 22; 7(16):2301-6. PMID: 21630446; PMCID: PMC3837553.
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    28. Harth KC, Broome AM, Jacobs MR, Blatnik JA, Zeinali F, Bajaksouzian S, Rosen MJ, Harth KC, Broome AM, Jacobs MR, Blatnik JA, Zeinali F, Bajaksouzian S, Rosen MJ. Bacterial clearance of biologic grafts used in hernia repair: an experimental study. Surg Endosc. 2011 Jul; 25(7):2224-9. PMID: 21298542; PMCID: PMC3148780.
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    29. Cheng Y, Meyers JD, Broome AM, Kenney ME, Basilion JP, Burda C, Cheng Y, Meyers JD, Broome AM, Kenney ME, Basilion JP, Burda C. Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates. J Am Chem Soc. 2011 Mar 02; 133(8):2583-91. PMID: 21294543; PMCID: PMC3056176.
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    30. Perera RH, Krupka TM, Wu H, Traughber B, Dremann D, Broome AM, Exner AA, Perera RH, Krupka TM, Wu H, Traughber B, Dremann D, Broome AM, Exner AA. Role of Pluronic block copolymers in modulation of heat shock protein 70 expression. Int J Hyperthermia. 2011; 27(7):672-81. PMID: 21992560; PMCID: PMC3294295.
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    31. Halaweish I, Harth K, Broome AM, Voskerician G, Jacobs MR, Rosen MJ, Halaweish I, Harth K, Broome AM, Voskerician G, Jacobs MR, Rosen MJ. Novel in vitro model for assessing susceptibility of synthetic hernia repair meshes to Staphylococcus aureus infection using green fluorescent protein-labeled bacteria and modern imaging techniques. Surg Infect (Larchmt). 2010 Oct; 11(5):449-54. PMID: 20815759; PMCID: PMC3155689.
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    32. Sandhu GS, Solorio L, Broome AM, Salem N, Kolthammer J, Shah T, Flask C, Duerk JL, Sandhu GS, Solorio L, Broome AM, Salem N, Kolthammer J, Shah T, Flask C, Duerk JL. Whole animal imaging. Wiley Interdiscip Rev Syst Biol Med. 2010 Jul-Aug; 2(4):398-421. PMID: 20836038; PMCID: PMC4437583.
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    33. Broome AM, Bhavsar N, Ramamurthy G, Newton G, Basilion JP, Broome AM, Bhavsar N, Ramamurthy G, Newton G, Basilion JP. Expanding the utility of beta-galactosidase complementation: piece by piece. Mol Pharm. 2010 Feb 01; 7(1):60-74. PMID: 19899815; PMCID: PMC2835542.
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    34. Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA, Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA. Transglutaminase function in epidermis. J Invest Dermatol. 2005 Mar; 124(3):481-92. PMID: 15737187.
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    35. Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA, Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA. Transglutaminases in epidermis. Prog Exp Tumor Res. 2005; 38:115-24. PMID: 15746532.
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    36. Efimova T, Broome AM, Eckert RL, Efimova T, Broome AM, Eckert RL. Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol. 2004 Sep; 24(18):8167-83. PMID: 15340077; PMCID: PMC515052.
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    37. Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K, Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K. S100 proteins in the epidermis. J Invest Dermatol. 2004 Jul; 123(1):23-33. PMID: 15191538.
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    38. Broome AM, Eckert RL, Broome AM, Eckert RL. Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J Invest Dermatol. 2004 Jan; 122(1):29-38. PMID: 14962086.
      Citations: 8     Fields:    Translation:HumansCells
    39. Sturniolo MT, Dashti SR, Deucher A, Rorke EA, Broome AM, Chandraratna RA, Keepers T, Eckert RL, Sturniolo MT, Dashti SR, Deucher A, Rorke EA, Broome AM, Chandraratna RA, Keepers T, Eckert RL. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J Biol Chem. 2003 Nov 28; 278(48):48066-73. PMID: 12928434.
      Citations: 25     Fields:    Translation:HumansCells
    40. Ruse M, Broome AM, Eckert RL, Ruse M, Broome AM, Eckert RL. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. J Invest Dermatol. 2003 Jul; 121(1):132-41. PMID: 12839573.
      Citations: 16     Fields:    Translation:HumansCells
    41. Efimova T, Broome AM, Eckert RL, Efimova T, Broome AM, Eckert RL. A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem. 2003 Sep 05; 278(36):34277-85. PMID: 12810719.
      Citations: 57     Fields:    Translation:HumansCells
    42. Broome AM, Ryan D, Eckert RL, Broome AM, Ryan D, Eckert RL. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem. 2003 May; 51(5):675-85. PMID: 12704215; PMCID: PMC3785113.
      Citations: 77     Fields:    Translation:HumansCells
    43. Morré DJ, Morré DM, Paulik M, Batova A, Broome AM, Pirisi L, Creek KE, Morr? DJ, Morr? DM, Paulik M, Batova A, Broome AM, Pirisi L, Creek KE. Retinoic acid and calcitriol inhibition of growth and NADH oxidase of normal and immortalized human keratinocytes. Biochim Biophys Acta. 1992 Apr 07; 1134(3):217-22. PMID: 1558845.
      Citations: 6     Fields:    Translation:HumansCells
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