Insulin-Like Growth Factor II
"Insulin-Like Growth Factor II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
| Descriptor ID |
D007335
|
| MeSH Number(s) |
D12.644.276.937.420 D12.776.124.862.425 D12.776.467.937.420 D23.529.937.420
|
| Concept/Terms |
Insulin-Like Growth Factor II- Insulin-Like Growth Factor II
- IGF-II
- Insulin Like Growth Factor II
- Insulin-Like Somatomedin Peptide II
- Insulin Like Somatomedin Peptide II
- Multiplication-Stimulating Factor
- Factor, Multiplication-Stimulating
- Multiplication Stimulating Factor
- Somatomedin A
- Somatomedin MSA
- IGF-2
- Multiplication-Stimulating Activity
- Multiplication Stimulating Activity
|
Below are MeSH descriptors whose meaning is more general than "Insulin-Like Growth Factor II".
Below are MeSH descriptors whose meaning is more specific than "Insulin-Like Growth Factor II".
This graph shows the total number of publications written about "Insulin-Like Growth Factor II" by people in this website by year, and whether "Insulin-Like Growth Factor II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 0 | 3 |
| 2005 | 2 | 2 | 4 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 3 | 0 | 3 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Insulin-Like Growth Factor II" by people in Profiles.
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Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling. Elife. 2020 03 13; 9.
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Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. PLoS One. 2019; 14(11):e0225422.
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Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development. BMC Dev Biol. 2019 03 25; 19(1):5.
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Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015 May 14; 58(9):3922-43.
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Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015 Mar 01; 105(3):271-8.
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Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond). 2013 Jul; 37(7):907-13.
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Phospholipase C and protein kinase C-? 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Mol Endocrinol. 2011 Dec; 25(12):2144-56.
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IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May; 138(9):1795-805.
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Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development. 2011 Jan; 138(1):139-48.
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Insulin-like growth factor-2/mannose-6 phosphate receptors. Vitam Horm. 2009; 80:667-97.