"Receptor, PAR-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.
| Descriptor ID |
D044463
|
| MeSH Number(s) |
D12.776.395.550.625.800.790 D12.776.543.550.625.800.790 D12.776.543.750.695.875.500 D12.776.543.750.705.675.892.790 D12.776.543.750.750.850.399 D12.776.543.750.792.500.500
|
| Concept/Terms |
Receptor, PAR-1- Receptor, PAR-1
- Receptor, PAR 1
- PAR1 Receptor
- Receptor, PAR1
- Protease-Activated Receptor 1
- Protease Activated Receptor 1
- PAR-1 Receptor
- PAR 1 Receptor
- Proteinase-Activated Receptor 1
- Proteinase Activated Receptor 1
|
Below are MeSH descriptors whose meaning is more general than "Receptor, PAR-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Platelet Membrane Glycoproteins [D12.776.395.550.625]
- Receptors, Thrombin [D12.776.395.550.625.800]
- Receptor, PAR-1 [D12.776.395.550.625.800.790]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Platelet Membrane Glycoproteins [D12.776.543.550.625]
- Receptors, Thrombin [D12.776.543.550.625.800]
- Receptor, PAR-1 [D12.776.543.550.625.800.790]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Thrombin [D12.776.543.750.695.875]
- Receptor, PAR-1 [D12.776.543.750.695.875.500]
- Receptors, Immunologic [D12.776.543.750.705]
- Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
- Receptors, Thrombin [D12.776.543.750.705.675.892]
- Receptor, PAR-1 [D12.776.543.750.705.675.892.790]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Thrombin [D12.776.543.750.750.850]
- Receptor, PAR-1 [D12.776.543.750.750.850.399]
- Receptors, Proteinase-Activated [D12.776.543.750.792]
- Receptors, Thrombin [D12.776.543.750.792.500]
- Receptor, PAR-1 [D12.776.543.750.792.500.500]
Below are MeSH descriptors whose meaning is more specific than "Receptor, PAR-1".
This graph shows the total number of publications written about "Receptor, PAR-1" by people in this website by year, and whether "Receptor, PAR-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 4 | 4 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptor, PAR-1" by people in Profiles.
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Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial. Blood Cells Mol Dis. 2018 09; 72:37-43.
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Protease-activated receptors in kidney disease progression. Am J Physiol Renal Physiol. 2016 12 01; 311(6):F1140-F1144.
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Efficacy and Safety of Vorapaxar in Non-ST-Segment Elevation Acute Coronary Syndrome Patients Undergoing Noncardiac Surgery. J Am Heart Assoc. 2015 Dec 15; 4(12).
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Vorapaxar in atherosclerotic disease management. Ann Pharmacother. 2015 May; 49(5):599-606.
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Thrombin increases lung fibroblast survival while promoting alveolar epithelial cell apoptosis via the endoplasmic reticulum stress marker, CCAAT enhancer-binding homologous protein. Am J Respir Cell Mol Biol. 2014 May; 50(5):893-902.
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Effect of vorapaxar on myocardial infarction in the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome (TRA?CER) trial. Eur Heart J. 2013 Jun; 34(23):1723-31.
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Modern antiplatelet agents in coronary artery disease. Expert Rev Cardiovasc Ther. 2012 Oct; 10(10):1261-72.
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Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med. 2012 Jan 05; 366(1):20-33.
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Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15.
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Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway. Biol Chem. 2010 Jul; 391(7):803-12.