"Neuregulin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A peptide factor originally identified by its ability to stimulate the phosphorylation the erbB-2 receptor (RECEPTOR, ERBB-2). It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Variant forms of NEUREGULIN-1 occur through alternative splicing of its mRNA.
Descriptor ID |
D020890
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MeSH Number(s) |
D12.644.276.860.550.750 D12.776.467.860.550.750 D12.776.631.600.550.750 D23.529.850.550.750
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Neuregulin-1".
Below are MeSH descriptors whose meaning is more specific than "Neuregulin-1".
This graph shows the total number of publications written about "Neuregulin-1" by people in this website by year, and whether "Neuregulin-1" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 1 | 0 | 1 |
2000 | 1 | 0 | 1 |
2001 | 0 | 1 | 1 |
2003 | 5 | 0 | 5 |
2004 | 1 | 2 | 3 |
2005 | 2 | 0 | 2 |
2006 | 1 | 1 | 2 |
2009 | 1 | 0 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2014 | 1 | 0 | 1 |
2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neuregulin-1" by people in Profiles.
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A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. J Clin Invest. 2018 05 01; 128(5):2025-2041.
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Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis. Acta Neuropathol. 2014 Apr; 127(4):573-91.
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Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis. Am J Pathol. 2013 Mar; 182(3):646-67.
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Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. Biol Psychiatry. 2012 Oct 15; 72(8):637-44.
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Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells. Glia. 2009 Nov 01; 57(14):1501-20.
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Interactions between beta-neuregulin and neurotrophins in motor neuron apoptosis. J Neurochem. 2006 Apr; 97(1):222-33.
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Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis. J Neuropathol Exp Neurol. 2006 Feb; 65(2):162-75.
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Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors. Oncogene. 2005 Aug 25; 24(36):5589-605.
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Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005 Aug 15; 51(3):217-28.
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Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons. Mol Cell Neurosci. 2004 Dec; 27(4):379-93.