"Neuregulins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).
| Descriptor ID |
D020880
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| MeSH Number(s) |
D12.644.276.860.550 D12.776.467.860.550 D12.776.631.600.550 D23.529.850.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Neuregulins".
Below are MeSH descriptors whose meaning is more specific than "Neuregulins".
This graph shows the total number of publications written about "Neuregulins" by people in this website by year, and whether "Neuregulins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neuregulins" by people in Profiles.
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Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition. Neuropsychopharmacology. 2018 05; 43(6):1343-1354.
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Role of the Neuregulin Signaling Pathway in Nicotine Dependence and Co-morbid Disorders. Int Rev Neurobiol. 2015; 124:113-31.
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Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus. Brain Res. 2008 May 07; 1208:67-73.
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Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan; 122(1):57-65.
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ErbB transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system. J Comp Neurol. 2001 Apr 23; 433(1):86-100.
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Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. J Neurosci. 1997 Mar 01; 17(5):1642-59.
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Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. Cell Growth Differ. 1996 May; 7(5):551-61.
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Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2. Mol Carcinog. 1996 Mar; 15(3):227-38.
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Growth factor-independent proliferation of rat mammary carcinoma cells by autocrine secretion of neu-differentiation factor/heregulin and transforming growth factor-alpha. Mol Carcinog. 1996 Feb; 15(2):134-43.
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Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas. Br J Cancer. 1995 Jul; 72(1):56-64.