"ras Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D018631
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.500 D12.644.360.525.500 D12.776.157.325.515.500 D12.776.476.525.500
|
| Concept/Terms |
ras Proteins- ras Proteins
- ras GTPases
- GTPases, ras
- Gene Products, ras
- ras Gene Products
|
Below are MeSH descriptors whose meaning is more general than "ras Proteins".
Below are MeSH descriptors whose meaning is more specific than "ras Proteins".
This graph shows the total number of publications written about "ras Proteins" by people in this website by year, and whether "ras Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 2 | 4 |
| 1997 | 4 | 1 | 5 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 2 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 3 | 4 | 7 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 1 | 3 |
| 2008 | 0 | 3 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 1 | 3 |
| 2011 | 0 | 2 | 2 |
| 2012 | 5 | 4 | 9 |
| 2013 | 3 | 2 | 5 |
| 2014 | 0 | 2 | 2 |
| 2015 | 3 | 2 | 5 |
| 2016 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 3 | 0 | 3 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 3 | 2 | 5 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "ras Proteins" by people in Profiles.
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Discovery of nonautonomous modulators of activated Ras. G3 (Bethesda). 2022 09 30; 12(10).
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells. Cell Commun Signal. 2021 09 16; 19(1):95.
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Targeting the "undruggable" RAS with biologics. Adv Cancer Res. 2022; 153:237-266.
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The RASopathies: Biology, genetics and therapeutic options. Adv Cancer Res. 2022; 153:305-341.
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The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change. Am J Pathol. 2021 09; 191(9):1499-1510.
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Probing RAS Function with Monobodies. Methods Mol Biol. 2021; 2262:281-302.
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Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
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Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
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Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
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ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms. Cell Commun Signal. 2019 07 10; 17(1):74.