The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.
The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells. J Pharmacol Exp Ther. 2003 Dec; 307(3):1142-7.
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8,11,14-Eicosatrienoic Acid
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Animals
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Autoradiography
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Blood Platelets
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Blood Proteins
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Blotting, Western
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Bridged Bicyclo Compounds, Heterocyclic
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Calcium
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Cells, Cultured
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Collagen
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COS Cells
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Densitometry
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Dose-Response Relationship, Drug
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Electrophoresis, Polyacrylamide Gel
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Fatty Acids, Unsaturated
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Humans
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Hydrazines
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In Vitro Techniques
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Isomerism
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Phosphoproteins
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Phosphorylation
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Radioligand Assay
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Receptors, Thromboxane
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Stimulation, Chemical
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Transfection