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    • A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.
    • Owings, James
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A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.

A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3056-64.

View in: PubMed

subject areas
  • Animals
  • Choroid
  • Choroidal Neovascularization
  • Complement Activation
  • Complement C3
  • Complement Factor H
  • Complement Pathway, Alternative
  • Disease Models, Animal
  • Electroretinography
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Infusions, Intravenous
  • Macular Degeneration
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Recombinant Fusion Proteins
  • Retina
  • Retinal Pigment Epithelium
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Up-Regulation
  • Vascular Endothelial Growth Factor A

authors with profiles
  • Stephen Tomlinson
  • Gary S. Gilkeson
  • Baerbel Rohrer