HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.

HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes. J Lipid Res. 2011 Nov; 52(11):2056-69.

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subject areas

Acetylation
Acetyltransferases
Adrenoleukodystrophy
Animals
Astrocytes
ATP-Binding Cassette Transporters
Blood-Brain Barrier
Cytokines
Down-Regulation
Fatty Acids
Fibroblasts
Gene Silencing
Histone Deacetylase Inhibitors
Histone Deacetylases
Humans
Hydroxamic Acids
Inflammation
Mice
Nitric Oxide Synthase Type II
Oxidation-Reduction
Oxidative Stress
Peroxisomes
RNA, Messenger
Skin

authors with profiles

Inderjit Singh
Mushfiquddin Khan