"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 2 | 3 |
| 1998 | 1 | 7 | 8 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 2 | 2 |
| 2001 | 2 | 7 | 9 |
| 2002 | 2 | 4 | 6 |
| 2003 | 5 | 11 | 16 |
| 2004 | 6 | 14 | 20 |
| 2005 | 0 | 16 | 16 |
| 2006 | 3 | 19 | 22 |
| 2007 | 1 | 15 | 16 |
| 2008 | 4 | 31 | 35 |
| 2009 | 2 | 17 | 19 |
| 2010 | 4 | 15 | 19 |
| 2011 | 5 | 10 | 15 |
| 2012 | 2 | 16 | 18 |
| 2013 | 2 | 14 | 16 |
| 2014 | 1 | 12 | 13 |
| 2015 | 2 | 13 | 15 |
| 2016 | 1 | 7 | 8 |
| 2017 | 1 | 9 | 10 |
| 2018 | 0 | 7 | 7 |
| 2019 | 0 | 10 | 10 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy. J Immunother Cancer. 2022 09; 10(9).
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NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons. FASEB J. 2022 04; 36(4):e22262.
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Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. FASEB J. 2021 02; 35(2):e21284.
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Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus. Genome Biol. 2020 11 19; 21(1):281.
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun. 2020 05 15; 11(1):2416.
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Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020 03; 579(7798):284-290.
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The Promising Signatures of Circulating microRNA-145 in Epithelial Ovarian Cancer Patients. Microrna. 2020; 9(1):49-57.
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Resveratrol Downregulates miR-31 to Promote T Regulatory Cells during Prevention of TNBS-Induced Colitis. Mol Nutr Food Res. 2020 01; 64(1):e1900633.
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Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism. Am J Physiol Endocrinol Metab. 2020 02 01; 318(2):E131-E144.
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Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells. Exp Gerontol. 2020 02; 130:110800.