"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
- 2 Amino 5 phosphonovalerate
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
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Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
Tu Y, Kroener S, Abernathy K, Lapish C, Seamans J, Chandler LJ, Woodward JJ. Ethanol inhibits persistent activity in prefrontal cortical neurons. J Neurosci. 2007 Apr 25; 27(17):4765-75.
Cornish JL, Nakamura M, Kalivas PW. Dopamine-independent locomotion following blockade of N-methyl-D-aspartate receptors in the ventral tegmental area. J Pharmacol Exp Ther. 2001 Jul; 298(1):226-33.
See RE, Kruzich PJ, Grimm JW. Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. Psychopharmacology (Berl). 2001 Mar; 154(3):301-10.
Cornish JL, Duffy P, Kalivas PW. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. 1999; 93(4):1359-67.
Robichon R, Randall PK, Leslie SW. A partial agonist model used in the allosteric modulation of the NMDA receptor. Eur J Pharmacol. 1997 Jun 11; 328(2-3):255-63.
Zhong J, Gribkoff VK, Molinoff PB. Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors. Mol Pharmacol. 1996 Sep; 50(3):631-8.
Williams K, Dichter MA, Molinoff PB. Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists. Mol Pharmacol. 1992 Jul; 42(1):147-51.
Leslie SW, Brown LM, Trent RD, Lee YH, Morris JL, Jones TW, Randall PK, Lau SS, Monks TJ. Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione. Mol Pharmacol. 1992 Feb; 41(2):308-14.
Lason W, Simpson JN, McGinty JF. Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid. Neurosci Lett. 1988 Apr 22; 87(1-2):23-8.