2-Amino-5-phosphonovalerate
"2-Amino-5-phosphonovalerate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Descriptor ID |
D015763
|
| MeSH Number(s) |
D12.125.070.950.100 D12.125.740.025
|
| Concept/Terms |
2-Amino-5-phosphonovalerate- 2-Amino-5-phosphonovalerate
- 2 Amino 5 phosphonovalerate
- 5-Phosphononorvaline
- 5 Phosphononorvaline
- 2-Amino-5-phosphonovaleric Acid
- 2 Amino 5 phosphonovaleric Acid
- 2-APV
- 2-Amino-5-phosphonopentanoate
- 2 Amino 5 phosphonopentanoate
- 2-Amino-5-phosphonopentanoic Acid
- 2 Amino 5 phosphonopentanoic Acid
|
Below are MeSH descriptors whose meaning is more general than "2-Amino-5-phosphonovalerate".
Below are MeSH descriptors whose meaning is more specific than "2-Amino-5-phosphonovalerate".
This graph shows the total number of publications written about "2-Amino-5-phosphonovalerate" by people in this website by year, and whether "2-Amino-5-phosphonovalerate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "2-Amino-5-phosphonovalerate" by people in Profiles.
-
Tu Y, Kroener S, Abernathy K, Lapish C, Seamans J, Chandler LJ, Woodward JJ. Ethanol inhibits persistent activity in prefrontal cortical neurons. J Neurosci. 2007 Apr 25; 27(17):4765-75.
-
Cornish JL, Nakamura M, Kalivas PW. Dopamine-independent locomotion following blockade of N-methyl-D-aspartate receptors in the ventral tegmental area. J Pharmacol Exp Ther. 2001 Jul; 298(1):226-33.
-
See RE, Kruzich PJ, Grimm JW. Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. Psychopharmacology (Berl). 2001 Mar; 154(3):301-10.
-
Cornish JL, Duffy P, Kalivas PW. A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience. 1999; 93(4):1359-67.
-
Robichon R, Randall PK, Leslie SW. A partial agonist model used in the allosteric modulation of the NMDA receptor. Eur J Pharmacol. 1997 Jun 11; 328(2-3):255-63.
-
Zhong J, Gribkoff VK, Molinoff PB. Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors. Mol Pharmacol. 1996 Sep; 50(3):631-8.
-
Williams K, Dichter MA, Molinoff PB. Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists. Mol Pharmacol. 1992 Jul; 42(1):147-51.
-
Leslie SW, Brown LM, Trent RD, Lee YH, Morris JL, Jones TW, Randall PK, Lau SS, Monks TJ. Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione. Mol Pharmacol. 1992 Feb; 41(2):308-14.
-
Lason W, Simpson JN, McGinty JF. Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid. Neurosci Lett. 1988 Apr 22; 87(1-2):23-8.