Eukaryotic Initiation Factor-2
"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
| Descriptor ID |
D015852
|
| MeSH Number(s) |
D12.776.835.725.868.249
|
| Concept/Terms |
Eukaryotic Initiation Factor-2- Eukaryotic Initiation Factor-2
- Eukaryotic Initiation Factor 2
- Initiation Factor-2, Eukaryotic
- Peptide Initiation Factor EIF-2
- Peptide Initiation Factor EIF 2
- Eukaryotic Peptide Initiation Factor-2
- Eukaryotic Peptide Initiation Factor 2
- EIF-2
- EIF 2
- EIF2
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in this website by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.
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Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer. Cancer Res. 2022 12 02; 82(23):4386-4399.
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The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment. Int J Mol Sci. 2021 Apr 26; 22(9).
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Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer. Curr Cancer Drug Targets. 2020; 20(3):223-238.
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Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease. Curr Alzheimer Res. 2019; 16(3):209-218.
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Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model. Hum Mol Genet. 2015 Dec 15; 24(24):7031-48.
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Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen. 2014 Aug; 19(7):1024-34.
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Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013 Mar; 27(3):965-77.
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Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene. 2013 Sep 05; 32(36):4214-21.
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MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum. 2010 May; 62(5):1361-71.
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PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16314-9.