Unfolded Protein Response
"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
| Descriptor ID |
D056811
|
| MeSH Number(s) |
G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
|
| Concept/Terms |
Unfolded Protein Response- Unfolded Protein Response
- Protein Response, Unfolded
- Protein Responses, Unfolded
- Response, Unfolded Protein
- Responses, Unfolded Protein
- Unfolded Protein Responses
|
Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".
Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".
This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 4 | 4 | 8 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 5 | 3 | 8 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 3 | 4 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.
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Small-molecule inhibitors of the PERK-mediated Unfolded Protein Response signaling pathway in targeted therapy for colorectal cancer. Pol Przegl Chir. 2022 Mar 15; 94(6):17-25.
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Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1. PLoS One. 2022; 17(1):e0261789.
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Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain. Dis Model Mech. 2021 10 01; 14(10).
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The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment. Int J Mol Sci. 2021 Apr 26; 22(9).
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The long and winding road to target protein misfolding in cardiovascular diseases. Eur J Clin Invest. 2021 May; 51(5):e13504.
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Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. J Pharmacol Exp Ther. 2021 04; 377(1):121-132.
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Coordination in the unfolded protein response during aging in outbred deer mice. Exp Gerontol. 2021 02; 144:111191.
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Coordination of the unfolded protein response during hepatic steatosis identifies CHOP as a specific regulator of hepatocyte ballooning. Cell Stress Chaperones. 2020 11; 25(6):969-978.
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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020 04 14; 52(4):668-682.e7.
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The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases. Int J Mol Sci. 2020 Mar 19; 21(6).