Dariusz Maciej Pytel

Title
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 509
HO 709
Hollings Cancer Center - 86 Jonathan Lucas St.
Phone843-792-6837
Fax843-792-8304
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mucha B, Qie S, Bajpai S, Tarallo V, Diehl JN, Tedeschi F, Zhou G, Gao Z, Flashner S, Klein-Szanto AJ, Hibshoosh H, Masataka S, Chajewski OS, Majsterek I, Pytel D, Hatzoglou M, Der CJ, Nakagawa H, Bass AJ, Wong KK, Fuchs SY, Rustgi AK, Jankowsky E, Diehl JA. Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation. Nat Commun. 2022 11 03; 13(1):6614. PMID: 36329064; PMCID: PMC9633729.
      Citations:    Fields:    Translation:HumansCells
    2. Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim DS, Pytel D, Kang I, Nadig SN, Beeson GC, Ball L, Mehrotra M, Wang H, Berto S, Palanisamy V, Li H, Chatterjee S, Rodriguez PC, Maldonado EN, Diehl JA, Gangaraju VK, Mehrotra S, Chakraborty P, Parikh RY, Choi S, Tran D, Gooz M, Hedley ZT, Kim DS, Pytel D, Kang I, Nadig SN, Beeson GC, Ball L, Mehrotra M, Wang H, Berto S, Palanisamy V, Li H, Chatterjee S, Rodriguez PC, Maldonado EN, Diehl JA, Gangaraju VK, Mehrotra S. Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function. Cancer Res. 2022 05 16; 82(10):1969-1990. PMID: 35404405; PMCID: PMC9117468.
      Citations: 4     Fields:    Translation:HumansCells
    3. Rozpedek-Kaminska W, Piotrzkowska D, Galita G, Pytel D, Kucharska E, Dziki L, Dziki A, Majsterek I. Small-molecule inhibitors of the PERK-mediated Unfolded Protein Response signaling pathway in targeted therapy for colorectal cancer. Pol Przegl Chir. 2022 Mar 15; 94(6):17-25. PMID: 36468513.
      Citations:    Fields:    Translation:HumansCells
    4. Rozpedek-Kaminska W, Galita G, Siwecka N, Carroll SL, Diehl JA, Kucharska E, Pytel D, Majsterek I, Rozpedek-Kaminska W, Galita G, Siwecka N, Carroll SL, Diehl JA, Kucharska E, Pytel D, Majsterek I. The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment. Int J Mol Sci. 2021 Apr 26; 22(9). PMID: 33925820; PMCID: PMC8123501.
      Citations:    
    5. Siwecka N, Rozpedek-Kaminska W, Wawrzynkiewicz A, Pytel D, Diehl JA, Majsterek I, Siwecka N, Rozpedek-Kaminska W, Wawrzynkiewicz A, Pytel D, Diehl JA, Majsterek I. The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate. Biomedicines. 2021 Feb 05; 9(2). PMID: 33562589; PMCID: PMC7914947.
      Citations:    
    6. Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I, Rozpedek-Kaminska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I. The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases. Int J Mol Sci. 2020 Mar 19; 21(6). PMID: 32204380; PMCID: PMC7139310.
      Citations:    
    7. Rozpedek W, Pytel D, Wawrzynkiewicz A, Siwecka N, Dziki A, Dziki L, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Wawrzynkiewicz A, Siwecka N, Dziki A, Dziki L, Diehl JA, Majsterek I. Use of Small-molecule Inhibitory Compound of PERK-dependent Signaling Pathway as a Promising Target-based Therapy for Colorectal Cancer. Curr Cancer Drug Targets. 2020; 20(3):223-238. PMID: 31906838.
      Citations:    
    8. Siwecka N, Rozpedek W, Pytel D, Wawrzynkiewicz A, Dziki A, Dziki L, Diehl JA, Majsterek I, Siwecka N, Rozpedek W, Pytel D, Wawrzynkiewicz A, Dziki A, Dziki L, Diehl JA, Majsterek I. Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis. Int J Mol Sci. 2019 Sep 05; 20(18). PMID: 31491919; PMCID: PMC6770252.
      Citations:    
    9. Basak J, Rozpedek W, Pytel D, Majsterek I, Basak J, Rozpedek W, Pytel D, Majsterek I. Potential therapeutic application of PERK inhibitors Postepy Biochem. 2019 06 06; 65(2):118-127. PMID: 31642650.
      Citations:    
    10. Poplawski T, Pytel D, Dziadek J, Majsterek I, Poplawski T, Pytel D, Dziadek J, Majsterek I. Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases. Oxid Med Cell Longev. 2019; 2019:6949347. PMID: 31089415; PMCID: PMC6476107.
      Citations:    
    11. Rozpedek W, Pytel D, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Diehl JA, Majsterek I. [Niskoczasteczkowe inhibitory szlaku adaptacyjnej odpowiedzi na stres zaleznego od kinazy PERK jako nowatorska strategia terapeutyczna w leczeniu choroby Alzheimera]. Pol Merkur Lekarski. 2019 Jan 28; 46(271):9-15. PMID: 30810108.
      Citations:    
    12. Kowalczyk T, Sitarek P, Skala E, Toma M, Wielanek M, Pytel D, Wieczfinska J, Szemraj J, Sliwinski T, Kowalczyk T, Sitarek P, Skala E, Toma M, Wielanek M, Pytel D, Wieczfinska J, Szemraj J, Sliwinski T. Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells. Cytotechnology. 2019 Feb; 71(1):165-180. PMID: 30610508; PMCID: PMC6368494.
      Citations:    
    13. Rozpedek W, Pytel D, Nowak-Zdunczyk A, Lewko D, Wojtczak R, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Nowak-Zdunczyk A, Lewko D, Wojtczak R, Diehl JA, Majsterek I. Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment. Curr Med Chem. 2019; 26(8):1425-1445. PMID: 29345572.
      Citations:    
    14. Rozpedek W, Pytel D, Poplawski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Poplawski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I. Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease. Curr Alzheimer Res. 2019; 16(3):209-218. PMID: 30819079.
      Citations:    
    15. Skala E, Kowalczyk T, Toma M, Szemraj J, Radek M, Pytel D, Wieczfinska J, Wysokinska H, Sliwinski T, Sitarek P, Skala E, Kowalczyk T, Toma M, Szemraj J, Radek M, Pytel D, Wieczfinska J, Wysokinska H, Sliwinski T, Sitarek P. Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract. Mol Cell Biochem. 2018 Aug; 445(1-2):89-97. PMID: 29238899.
      Citations:    
    16. Rozpedek W, Pytel D, Dziki L, Nowak A, Dziki A, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Dziki L, Nowak A, Dziki A, Diehl JA, Majsterek I. Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment. Pol Przegl Chir. 2017 Jun 30; 89(3):7-10. PMID: 28703114.
      Citations:    
    17. Sitarek P, Rijo P, Garcia C, Skala E, Kalemba D, Bialas AJ, Szemraj J, Pytel D, Toma M, Wysokinska H, Sliwinski T, Sitarek P, Rijo P, Garcia C, Skala E, Kalemba D, Bialas AJ, Szemraj J, Pytel D, Toma M, Wysokinska H, Sliwinski T. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition. Oxid Med Cell Longev. 2017; 2017:7384061. PMID: 28191277; PMCID: PMC5278227.
      Citations:    
    18. Mucha B, Pytel D, Markiewicz L, Cuchra M, Szymczak I, Przybylowska-Sygut K, Dziki A, Majsterek I, Dziki L, Mucha B, Pytel D, Markiewicz L, Cuchra M, Szymczak I, Przybylowska-Sygut K, Dziki A, Majsterek I, Dziki L. Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk. Clin Colorectal Cancer. 2018 06; 17(2):e435-e441. PMID: 29793654.
      Citations:    
    19. Skala E, Rijo P, Garcia C, Sitarek P, Kalemba D, Toma M, Szemraj J, Pytel D, Wysokinska H, Sliwinski T, Skala E, Rijo P, Garcia C, Sitarek P, Kalemba D, Toma M, Szemraj J, Pytel D, Wysokinska H, Sliwinski T. The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities. Oxid Med Cell Longev. 2016; 2016:8505384. PMID: 28074117; PMCID: PMC5203915.
      Citations:    
    20. Pytel D, Gao Y, Mackiewicz K, Katlinskaya YV, Staschke KA, Paredes MC, Yoshida A, Qie S, Zhang G, Chajewski OS, Wu L, Majsterek I, Herlyn M, Fuchs SY, Diehl JA, Pytel D, Gao Y, Mackiewicz K, Katlinskaya YV, Staschke KA, Paredes MC, Yoshida A, Qie S, Zhang G, Chajewski OS, Wu L, Majsterek I, Herlyn M, Fuchs SY, Diehl JA. PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet. 2016 Dec; 12(12):e1006518. PMID: 27977682; PMCID: PMC5207760.
      Citations:    
    21. Rozpedek W, Pytel D, Diehl JA, Majsterek I, Rozpedek W, Pytel D, Diehl JA, Majsterek I. [Small molecule inhibitors of PERK-dependent signaling pathway as a novel, therapeutic molecular strategy in Alzheimer's disease treatment]. Pol Merkur Lekarski. 2016 Jul 29; 41(241):5-10. PMID: 27734813.
      Citations:    
    22. Rozpedek W, Markiewicz L, Diehl JA, Pytel D, Majsterek I, Rozpedek W, Markiewicz L, Diehl JA, Pytel D, Majsterek I. [The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2]. Pol Merkur Lekarski. 2015 Dec; 39(234):393-7. PMID: 26802695.
      Citations:    
    23. Cuchra M, Mucha B, Markiewicz L, Przybylowska-Sygut K, Pytel D, Jeziorski A, Kordek R, Majsterek I, Cuchra M, Mucha B, Markiewicz L, Przybylowska-Sygut K, Pytel D, Jeziorski A, Kordek R, Majsterek I. The role of base excision repair in pathogenesis of breast cancer in the Polish population. Mol Carcinog. 2016 12; 55(12):1899-1914. PMID: 27870262.
      Citations:    
    24. Cuchra M, Markiewicz L, Mucha B, Pytel D, Szymanek K, Szemraj J, Szaflik J, Szaflik JP, Majsterek I, Cuchra M, Markiewicz L, Mucha B, Pytel D, Szymanek K, Szemraj J, Szaflik J, Szaflik JP, Majsterek I. The role of base excision repair in the development of primary open angle glaucoma in the Polish population. Mutat Res. 2015 Aug; 778:26-40. PMID: 26056729.
      Citations:    
    25. Markiewicz L, Pytel D, Mucha B, Szymanek K, Szaflik J, Szaflik JP, Majsterek I, Markiewicz L, Pytel D, Mucha B, Szymanek K, Szaflik J, Szaflik JP, Majsterek I. Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1? as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients. Biomed Res Int. 2015; 2015:812503. PMID: 26120586; PMCID: PMC4442285.
      Citations:    
    26. Nowak A, Majsterek I, Przybylowska-Sygut K, Pytel D, Szymanek K, Szaflik J, Szaflik JP, Nowak A, Majsterek I, Przybylowska-Sygut K, Pytel D, Szymanek K, Szaflik J, Szaflik JP. Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the neurodegeneration process in the pathogenesis of primary open angle glaucoma. Biomed Res Int. 2015; 2015:258281. PMID: 25893192; PMCID: PMC4393917.
      Citations:    
    27. Rozpedek W, Markiewicz L, Diehl JA, Pytel D, Majsterek I, Rozpedek W, Markiewicz L, Diehl JA, Pytel D, Majsterek I. Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease. Curr Med Chem. 2015; 22(27):3169-84. PMID: 26282939; PMCID: PMC5010237.
      Citations:    
    28. Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA, Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen. 2014 Aug; 19(7):1024-34. PMID: 24598103; PMCID: PMC4570879.
      Citations:    
    29. Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA, Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA. The ? isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal. 2013 Nov 26; 6(303):ra102. PMID: 24280043; PMCID: PMC4096120.
      Citations:    
    30. Lee EK, Lian Z, D'Andrea K, Letrero R, Sheng W, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L, Amaravaradi R, Xu X, Herlyn M, Nathanson KL, Diehl JA, Lee EK, Lian Z, D'Andrea K, Letrero R, Sheng W, Liu S, Diehl JN, Pytel D, Barbash O, Schuchter L, Amaravaradi R, Xu X, Herlyn M, Nathanson KL, Diehl JA. The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol. 2013 Nov; 33(22):4422-33. PMID: 24019069; PMCID: PMC3838190.
      Citations:    
    31. Chitnis N, Pytel D, Diehl JA, Chitnis N, Pytel D, Diehl JA. UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci. 2013 Sep; 38(9):447-52. PMID: 23906563; PMCID: PMC4056666.
      Citations:    
    32. Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA, Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell. 2012 Nov 09; 48(3):353-64. PMID: 23022383; PMCID: PMC3496065.
      Citations:    
    33. Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA, Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA. PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation. Mol Cell Biol. 2012 Jun; 32(12):2268-78. PMID: 22493067; PMCID: PMC3372262.
      Citations:    
    34. Slupianek A, Poplawski T, Jozwiakowski SK, Cramer K, Pytel D, Stoczynska E, Nowicki MO, Blasiak J, Skorski T, Slupianek A, Poplawski T, Jozwiakowski SK, Cramer K, Pytel D, Stoczynska E, Nowicki MO, Blasiak J, Skorski T. BCR/ABL stimulates WRN to promote survival and genomic instability. Cancer Res. 2011 Feb 01; 71(3):842-51. PMID: 21123451; PMCID: PMC3032814.
      Citations:    
    35. Rusin P, Walczak A, Zwierzchlejska A, Olszewski J, Morawiec-Bajda A, Kaczmarczyk D, Kusmierczyk K, Garncarek P, Pytel D, Sliwinnski T, Majsterek I, Rusin P, Walczak A, Zwierzchlejska A, Olszewski J, Morawiec-Bajda A, Kaczmarczyk D, Kusmierczyk K, Garncarek P, Pytel D, Sliwinnski T, Majsterek I. DNA damage and repair of head and neck cancer cells after radio- and chemotherapy. Z Naturforsch C J Biosci. 2009 Jul-Aug; 64(7-8):601-10. PMID: 19791515.
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    36. Pytel D, Sliwinski T, Poplawski T, Ferriola D, Majsterek I, Pytel D, Sliwinski T, Poplawski T, Ferriola D, Majsterek I. Tyrosine kinase blockers: new hope for successful cancer therapy. Anticancer Agents Med Chem. 2009 Jan; 9(1):66-76. PMID: 19149483.
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    37. Pytel D, Slupianek A, Ksiazek D, Skórski T, Blasiak J, Pytel D, Slupianek A, Ksiazek D, Sk?rski T, Blasiak J. [Uracil-DNA glycosylases]. Postepy Biochem. 2008; 54(4):362-70. PMID: 19248582.
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    38. Slupianek A, Pytel D, Majsterek I, Slupianek A, Pytel D, Majsterek I. [The role of oncogenic tyrosine kinases in the cellular response to anticancer therapy]. Postepy Hig Med Dosw (Online). 2007 Dec 14; 61:819-27. PMID: 18097340.
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    39. Majsterek I, Arabski M, Czechowska A, Pytel D, Morawiec Z, Morawiec-Bajda A, Blasiak J, Majsterek I, Arabski M, Czechowska A, Pytel D, Morawiec Z, Morawiec-Bajda A, Blasiak J. Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells. Z Naturforsch C J Biosci. 2006 Nov-Dec; 61(11-12):896-902. PMID: 17294703.
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    40. Pytel D, Wysocki T, Majsterek I, Pytel D, Wysocki T, Majsterek I. Comparative study of DNA damage, cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells: role of BCR/ABL in therapeutic resistance. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Sep; 144(1):85-92. PMID: 16904383.
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    41. Majsterek I, Sliwinski T, Poplawski T, Pytel D, Kowalski M, Slupianek A, Skorski T, Blasiak J, Majsterek I, Sliwinski T, Poplawski T, Pytel D, Kowalski M, Slupianek A, Skorski T, Blasiak J. Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair. Mutat Res. 2006 Jan 31; 603(1):74-82. PMID: 16388976.
      Citations:    
    42. Majsterek I, Pytel D, Blasiak J, Majsterek I, Pytel D, Blasiak J. [Tyrosine kinases. New target of anticancer therapy]. Postepy Biochem. 2005; 51(3):251-60. PMID: 16381169.
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