"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
| Descriptor ID |
D005804
|
| MeSH Number(s) |
G05.360.340.024.340.350
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".
Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".
This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2006 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, Lethal" by people in Profiles.
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells. J Vis Exp. 2021 08 25; (174).
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Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins. Hum Genet. 2016 May; 135(5):569-586.
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Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality. In Vivo. 2014 Sep-Oct; 28(5):709-18.
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Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet. 2013; 9(2):e1003279.
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Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17; 22(4):849-62.
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The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J. 2010 Jun; 24(6):1947-57.
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Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35.
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Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev. 2006 Dec; 123(12):869-80.
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Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006 Jun 20; 6:30.
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Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev Biol. 2006 Apr 12; 6:19.