"Sp7 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An Sp transcription factor that contains three CYS2-HIS2 ZINC FINGERS. It binds to GC RICH SEQUENCES and performs an essential function in regulating gene expression for differentiation of OSTEOBLASTS. Mutations in the SP7 gene are associated with type 12 OSTEOGENESIS IMPERFECTA.
| Descriptor ID |
D000076182
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| MeSH Number(s) |
D12.776.260.522.750.937 D12.776.930.375.750.937
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sp7 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp7 Transcription Factor".
This graph shows the total number of publications written about "Sp7 Transcription Factor" by people in this website by year, and whether "Sp7 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sp7 Transcription Factor" by people in Profiles.
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Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix. Bone. 2014 Dec; 69:30-8.
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Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor a action in osteoblast differentiation. J Bone Miner Res. 2011 Jan; 26(1):209-19.
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The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation. Mol Endocrinol. 2007 Feb; 21(2):376-87.