Discoidin Domain Receptors
"Discoidin Domain Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.
| Descriptor ID |
D000070818
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.005 D12.776.543.750.630.005 D12.776.543.750.685.050 D12.776.543.750.705.880.300
|
| Concept/Terms |
Discoidin Domain Receptors- Discoidin Domain Receptors
- Receptors, Discoidin Domain
- DDR Proteins
- Proteins, DDR
- Discoidin Domain Receptor
- Receptor, Discoidin Domain
|
Below are MeSH descriptors whose meaning is more general than "Discoidin Domain Receptors".
Below are MeSH descriptors whose meaning is more specific than "Discoidin Domain Receptors".
This graph shows the total number of publications written about "Discoidin Domain Receptors" by people in this website by year, and whether "Discoidin Domain Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Discoidin Domain Receptors" by people in Profiles.
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May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for? J Mol Cell Cardiol. 2016 Feb; 91:201-3.
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Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol. 2014 May; 70:92-9.
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The collagen receptor DDR2 is expressed during early cardiac development. Anat Rec (Hoboken). 2010 May; 293(5):762-9.
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Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. 2006 Feb; 34(2):219-29.
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Expression of Discoidin Domain Receptor 2 (DDR2) in the developing heart. Microsc Microanal. 2005 Jun; 11(3):260-7.
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Organization of fibroblasts in the heart. Dev Dyn. 2004 Aug; 230(4):787-94.