MEF2 Transcription Factors

"MEF2 Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.

Descriptor ID	D064326
MeSH Number(s)	D12.776.210.500.570.294 D12.776.260.103.750.294 D12.776.260.400.249.624 D12.776.930.125.750.294 D12.776.930.397.700
Concept/Terms	MEF2 Transcription Factors MEF2 Transcription Factors Transcription Factors, MEF2 Muscle Enhancer Factor-2 Enhancer Factor-2, Muscle Muscle Enhancer Factor 2 Myocyte-Specific Enhancer-Binding Factor 2 Myocyte Specific Enhancer Binding Factor 2 Myocyte Enhancer Factor 2 Myocyte-Specific Enhancer Factor 2 Myocyte Specific Enhancer Factor 2 MEF2 Proteins Muscle-Specific Enhancer Factor-2 Enhancer Factor-2, Muscle-Specific Muscle Specific Enhancer Factor 2 MEF2B Transcription Factor MEF2B Transcription Factor Transcription Factor, MEF2B Serum Response Factor-Like Protein 2 Serum Response Factor Like Protein 2 Myocyte-Specific Enhancer Factor 2B Myocyte Specific Enhancer Factor 2B Muscle Enhancer Factor-2B Enhancer Factor-2B, Muscle Muscle Enhancer Factor 2B Muscle-Specific Enhancer Factor-2B Enhancer Factor-2B, Muscle-Specific Muscle Specific Enhancer Factor 2B Myocyte Enhancer Factor 2B Myocyte-Specific Enhancer-Binding Factor 2B Myocyte Specific Enhancer Binding Factor 2B MEF2B Protein MEF2D Transcription Factor MEF2D Transcription Factor Transcription Factor, MEF2D Muscle Enhancer Factor-2D Enhancer Factor-2D, Muscle Muscle Enhancer Factor 2D Muscle-Specific Enhancer Factor-2D Enhancer Factor-2D, Muscle-Specific Muscle Specific Enhancer Factor 2D Myocyte-Specific Enhancer Factor 2D Myocyte Specific Enhancer Factor 2D Myocyte-Specific Enhancer-Binding Factor 2D Myocyte Specific Enhancer Binding Factor 2D MEF2D Protein Myocyte Enhancer Factor 2D MEF2A Transcription Factor MEF2A Transcription Factor Transcription Factor, MEF2A Muscle Enhancer Factor-2A Enhancer Factor-2A, Muscle Muscle Enhancer Factor 2A Serum Response Factor-Like Protein 1 Serum Response Factor Like Protein 1 Myocyte Enhancer Factor 2A Myocyte-Specific Enhancer Factor 2A Myocyte Specific Enhancer Factor 2A Myocyte-Specific Enhancer-Binding Factor 2A Myocyte Specific Enhancer Binding Factor 2A MEF2A Protein Muscle-Specific Enhancer Factor-2A Enhancer Factor-2A, Muscle-Specific Muscle Specific Enhancer Factor 2A MEF2C Transcription Factor MEF2C Transcription Factor Transcription Factor, MEF2C Muscle Enhancer Factor-2C Enhancer Factor-2C, Muscle Muscle Enhancer Factor 2C Myocyte-Specific Enhancer-Binding Factor 2C Myocyte Specific Enhancer Binding Factor 2C Myocyte Enhancer Factor 2C Myocyte-Specific Enhancer Factor 2C Myocyte Specific Enhancer Factor 2C MEF2C Protein Muscle-Specific Enhancer Factor-2C Enhancer Factor-2C, Muscle-Specific Muscle Specific Enhancer Factor 2C

Below are MeSH descriptors whose meaning is more general than "MEF2 Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Myogenic Regulatory Factors [D12.776.210.500.570]
MEF2 Transcription Factors [D12.776.210.500.570.294]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Myogenic Regulatory Factors [D12.776.260.103.750]
MEF2 Transcription Factors [D12.776.260.103.750.294]
Homeodomain Proteins [D12.776.260.400]
MADS Domain Proteins [D12.776.260.400.249]
MEF2 Transcription Factors [D12.776.260.400.249.624]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Myogenic Regulatory Factors [D12.776.930.125.750]
MEF2 Transcription Factors [D12.776.930.125.750.294]
MADS Domain Proteins [D12.776.930.397]
MEF2 Transcription Factors [D12.776.930.397.700]

Below are MeSH descriptors whose meaning is related to "MEF2 Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "MEF2 Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MEF2 Transcription Factors" by people in this website by year, and whether "MEF2 Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 17 publications over 12 distinct years, with a maximum of 2 publications in 2008 and 2013 and 2016 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	0	1	1
2008	0	2	2
2009	0	1	1
2010	0	1	1
2013	1	1	2
2015	0	1	1
2016	0	2	2
2018	0	1	1
2019	0	2	2
2020	0	2	2
2022	0	1	1

Below are the most recent publications written about "MEF2 Transcription Factors" by people in Profiles.

Cooley Coleman JA, Sarasua SM, Moore HW, Boccuto L, Cowan CW, Skinner SA, DeLuca JM. Clinical findings from the landmark MEF2C-related disorders natural history study. Mol Genet Genomic Med. 2022 06; 10(6):e1919.

View in: PubMed
Bjorness TE, Kulkarni A, Rybalchenko V, Suzuki A, Bridges C, Harrington AJ, Cowan CW, Takahashi JS, Konopka G, Greene RW. An essential role for MEF2C in the cortical response to loss of sleep in mice. Elife. 2020 08 27; 9.

View in: PubMed
Harrington AJ, Bridges CM, Berto S, Blankenship K, Cho JY, Assali A, Siemsen BM, Moore HW, Tsvetkov E, Thielking A, Konopka G, Everman DB, Scofield MD, Skinner SA, Cowan CW. MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in Mice. Biol Psychiatry. 2020 09 15; 88(6):488-499.

View in: PubMed
Assali A, Harrington AJ, Cowan CW. Emerging roles for MEF2 in brain development and mental disorders. Curr Opin Neurobiol. 2019 12; 59:49-58.

View in: PubMed
Poltavski DM, Colombier P, Hu J, Duron A, Black BL, Makita T. Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin. Elife. 2019 02 08; 8.

View in: PubMed
Burns TA, Deepe RN, Bullard J, Phelps AL, Toomer KA, Hiriart E, Norris RA, Haycraft CJ, Wessels A. A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return. Anat Rec (Hoboken). 2019 01; 302(1):136-145.

View in: PubMed
Harrington AJ, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, Raduazzo J, Guo Y, Loerwald K, Konopka G, Huber KM, Cowan CW. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife. 2016 10 25; 5.

View in: PubMed
Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL. MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016 Mar 01; 143(5):774-9.

View in: PubMed
Tseng YC, Kulp SK, Lai IL, Hsu EC, He WA, Frankhouser DE, Yan PS, Mo X, Bloomston M, Lesinski GB, Marcucci G, Guttridge DC, Bekaii-Saab T, Chen CS. Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. J Natl Cancer Inst. 2015 Dec; 107(12):djv274.

View in: PubMed
Zang T, Maksimova MA, Cowan CW, Bassel-Duby R, Olson EN, Huber KM. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol Cell Neurosci. 2013 Sep; 56:39-49.

View in: PubMed

People

Explore

Similar Concepts

Top Journals