"DNA Polymerase gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
| Descriptor ID |
D000074002
|
| MeSH Number(s) |
D08.811.913.696.445.308.300.169 D12.776.575.280
|
| Concept/Terms |
DNA Polymerase gamma- DNA Polymerase gamma
- Polymerase gamma, DNA
- Mitochondrial DNA Polymerase
- DNA Polymerase, Mitochondrial
- Polymerase, Mitochondrial DNA
|
Below are MeSH descriptors whose meaning is more general than "DNA Polymerase gamma".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase gamma".
This graph shows the total number of publications written about "DNA Polymerase gamma" by people in this website by year, and whether "DNA Polymerase gamma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase gamma" by people in Profiles.
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Zebrafish lacking functional DNA polymerase gamma survive to juvenile stage, despite rapid and sustained mitochondrial DNA depletion, altered energetics and growth. Nucleic Acids Res. 2015 Dec 02; 43(21):10338-52.
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Mitochondrial disorders of DNA polymerase ? dysfunction: from anatomic to molecular pathology diagnosis. Arch Pathol Lab Med. 2011 Jul; 135(7):925-34.
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De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion. 2009 Sep; 9(5):340-5.
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Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. J Biol Chem. 2009 Jul 17; 284(29):19501-10.
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Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease. Methods Mol Biol. 2009; 554:59-72.
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DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Biochim Biophys Acta. 2009 May; 1787(5):312-9.
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Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Hum Mol Genet. 2006 Dec 01; 15(23):3473-83.
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Molecular diagnosis of Alpers syndrome. J Hepatol. 2006 Jul; 45(1):108-16.
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Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest. 2007 Apr; 87(4):326-35.
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Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. DNA Repair (Amst). 2005 Dec 08; 4(12):1381-9.