"Complement C5a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
| Descriptor ID |
D015936
|
| MeSH Number(s) |
D12.776.124.486.274.024.270 D12.776.124.486.274.450.250
|
| Concept/Terms |
Complement C5a- Complement C5a
- C5a, Complement
- C5a Complement
- Complement, C5a
- Complement Component 5a
- Component 5a, Complement
- Complement 5a
|
Below are MeSH descriptors whose meaning is more general than "Complement C5a".
Below are MeSH descriptors whose meaning is more specific than "Complement C5a".
This graph shows the total number of publications written about "Complement C5a" by people in this website by year, and whether "Complement C5a" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Complement C5a" by people in Profiles.
-
Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent. Mol Vis. 2019; 25:79-92.
-
An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Semin Immunol. 2018 06; 37:30-42.
-
Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Relevance to Age-Related Macular Degeneration. Adv Exp Med Biol. 2018; 1074:45-51.
-
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease. Nature. 2017 03 02; 543(7643):108-112.
-
Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and ?dT-cells. Sci Rep. 2016 Mar 31; 6:23794.
-
Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6061-6.
-
Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines. Vaccine. 2009 May 14; 27(22):2981-8.
-
Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction. Transplantation. 2006 Jun 27; 81(12):1686-94.
-
Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol. 2005 Jun; 115(6):1162-8.
-
Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. Clin Exp Allergy. 2005 May; 35(5):554-9.