Complement Membrane Attack Complex
"Complement Membrane Attack Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
| Descriptor ID |
D015938
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| MeSH Number(s) |
D12.776.124.486.274.930
|
| Concept/Terms |
Complement Membrane Attack Complex- Complement Membrane Attack Complex
- C5b-8-poly-C9
- C5b 8 poly C9
- Terminal Complement Complex
- Complement Complex, Terminal
- Complex, Terminal Complement
- Complement Complex C5b-9
- Complement Complex C5b 9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- C 5b-9
- C5b-9
|
Below are MeSH descriptors whose meaning is more general than "Complement Membrane Attack Complex".
Below are MeSH descriptors whose meaning is more specific than "Complement Membrane Attack Complex".
This graph shows the total number of publications written about "Complement Membrane Attack Complex" by people in this website by year, and whether "Complement Membrane Attack Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Membrane Attack Complex" by people in Profiles.
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Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury. J Neurosci. 2018 03 07; 38(10):2519-2532.
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Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. J Exp Med. 2014 Aug 25; 211(9):1793-805.
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The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization. Adv Exp Med Biol. 2014; 801:435-40.
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The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7.
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Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol. 2012; 723:23-30.
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Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure. PLoS One. 2011; 6(11):e26838.
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Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem. 2011 Jul 08; 286(27):23717-24.
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Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex. Acta Crystallogr D Biol Crystallogr. 2007 Jun; 63(Pt 6):714-21.
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Insights into the human CD59 complement binding interface toward engineering new therapeutics. J Biol Chem. 2005 Oct 07; 280(40):34073-9.
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Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. J Immunol. 2005 May 01; 174(9):5750-7.