"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
|
| MeSH Number(s) |
D03.132.206.636 D03.605.687.637 D03.633.100.810.699
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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Meissner EG, McGillicuddy JW, Squires J, Skipper D, Self S, Wray D, Moritz ED, Stramer SL, Nadig S. Across state lines: Fulminant Babesia microti infection in a liver transplant recipient. Transpl Infect Dis. 2017 Oct; 19(5).
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Adegbola AJ, Soyinka JO, Adeagbo BA, Igbinoba SI, Nathaniel TI. Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration. Am J Ther. 2016 Mar-Apr; 23(2):e398-404.
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Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, De La Gandara JE, Agronin M, Davis CS, Nguyen U, Shin P, Tariot PN, Siffert J. Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29; 314(12):1242-54.
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Igbinoba SI, Onyeji CO, Akanmu MA, Soyinka JO, Pullela SS, Cook JM, Nathaniel TI. Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers. J Clin Pharmacol. 2015 Mar; 55(3):348-54.
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de Dios AC, Casabianca LB, Kosar A, Roepe PD. Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution. Inorg Chem. 2004 Dec 13; 43(25):8078-84.
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DeVane CL, Markowitz JS, Carson SW, Boulton DW, Gill HS, Nahas Z, Risch SC. Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers. J Clin Psychopharmacol. 2000 Jun; 20(3):347-9.
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Tecklenburg FW, Thomas NJ, Webb SA, Case C, Habib DM. Pediatric ECMO for severe quinidine cardiotoxicity. Pediatr Emerg Care. 1997 Apr; 13(2):111-3.
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Cooke CE, Sklar GE, Nappi JM. Possible pharmacokinetic interaction with quinidine: ciprofloxacin or metronidazole? Ann Pharmacother. 1996 Apr; 30(4):364-6.
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Buchanan D, Gillette PC, Zinner A, Crawford F. Ventricular tachydysrhythmias in near-miss sudden infant death syndrome. Am Heart J. 1986 Feb; 111(2):398-400.