Immunoglobulin Variable Region
"Immunoglobulin Variable Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.
| Descriptor ID |
D007135
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| MeSH Number(s) |
D12.644.541.500.650.500 D12.776.124.486.485.680.650.500 D12.776.124.486.485.797 D12.776.124.790.651.680.650.500 D12.776.124.790.651.797 D12.776.377.715.548.680.650.500 D12.776.377.715.548.797 G02.111.570.060.425
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| Concept/Terms |
Immunoglobulin Variable Region- Immunoglobulin Variable Region
- Immunoglobulin Variable Regions
- Regions, Immunoglobulin Variable
- Variable Regions, Immunoglobulin
- Ig Variable Region
- Variable Region, Ig
- Ig Variable Regions
- Variable Regions, Ig
- Variable Region, Immunoglobulin
- Immunoglobulin V
Immunoglobulin Fv Fragments- Immunoglobulin Fv Fragments
- Fragment, Immunoglobulin Fv
- Fragments, Immunoglobulin Fv
- Fv Fragment, Immunoglobulin
- Fv Fragments, Immunoglobulin
- Immunoglobulin Fv Fragment
- Fv Antibody Fragments
- Antibody Fragment, Fv
- Antibody Fragments, Fv
- Fragment, Fv Antibody
- Fragments, Fv Antibody
- Fv Antibody Fragment
- Fv Fragments
- Fragment, Fv
- Fragments, Fv
- Fv Fragment
Framework Region, Immunoglobulin- Framework Region, Immunoglobulin
- Framework Regions, Immunoglobulin
- Immunoglobulin Framework Regions
- Ig Framework Region
- Framework Region, Ig
- Framework Regions, Ig
- Ig Framework Regions
- Immunoglobulin Framework Region
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Variable Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Variable Region".
This graph shows the total number of publications written about "Immunoglobulin Variable Region" by people in this website by year, and whether "Immunoglobulin Variable Region" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Variable Region" by people in Profiles.
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Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia. Leuk Lymphoma. 2018 04; 59(4):1008-1011.
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Traumatic ulcerative granuloma with stromal eosinophilia: report of a case and literature review. J Oral Maxillofac Surg. 2012 Feb; 70(2):349-53.
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Modeling of human anti-GBM antibody-alpha3(IV)NC1 interactions predicts antigenic cross-linking through contact of both heavy chains with repeating epitopes on alpha3(IV)NC1. Am J Nephrol. 2009; 30(5):474-80.
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Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment. Mol Immunol. 2008 May; 45(9):2570-80.
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Characterization of the 4D5Flu single-chain antibody with a stimulus-responsive elastin-like peptide linker: a potential reporter of peptide linker conformation. Protein Sci. 2008 Mar; 17(3):527-36.
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Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene. Immunogenetics. 2006 Oct; 58(10):831-44.
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Artificial T-cell receptors. Cytotherapy. 2003; 5(3):211-26.
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Cloning of the IgM heavy chain of the bottlenose dolphin (Tursiops truncatus), and initial analysis of VH gene usage. Dev Comp Immunol. 2002 Jul; 26(6):551-62.
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The antibody site in Atlantic salmon; phage display and modeling of scFv with anti-hapten binding ability. Dev Comp Immunol. 2002 Mar; 26(2):201-6.
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Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci. Dev Comp Immunol. 2001 Jun-Jul; 25(5-6):403-17.